Abstract: A steering column includes an outer jacket that is adjustably secured to a carrier unit and clamped to a telescopically adjustable inner jacket. The outer jacket has a tubular body with a clamping slot extending longitudinally. Opposing side plates disposed alongside the clamping slot extend longitudinally. The side plates are connected to the tubular body and each have a longitudinally-extending elongated hole spaced apart from the tubular body in an outer region that protrudes from the tubular body. A clamping bolt extends through the elongated holes and an opening of the carrier unit. The clamping bolt applies a clamping force to load the side plates. An inner region of each side plate is fixed to the tubular body. A support element is connected to each side plate between the elongated hole and the inner region and is connected to the tubular body in an edge region of the clamping slot.

Abstract: A steering column for a motor vehicle may include an inner casing in which a steering spindle is mounted rotatably about a longitudinal axis that extends in a longitudinal direction and is received in an outer casing in a slidingly adjustable manner in the longitudinal direction. A pretensioning apparatus may have a pressure piece that can be braced from an outside in a tensioning direction transversely to the longitudinal axis against the inner casing. The pressure piece is held in the longitudinal direction on the outer casing and is supported against a fixing element counter to the tensioning direction. The fixing element is fixed in a recess of the outer casing. The fixing element has a forming means that is plastically furrowed into the recess, and/or the recess has a forming means that is plastically furrowed into the fixing element.

Abstract: The present disclosure provides processes and apparatuses for the scaled-up manufacture of lomustine via continuous flow manufacture. Such continuous flow processes may optionally include the crystallization of lomustine and the apparatuses may optionally include crystallization apparatuses/reactors in either batch or continuous flow design. In one aspect of the disclosure, a process for making lomustine is provided comprising treating solutions of 2-chloroethylisocyanate with a solution of cyclohexylamine with continuous-flow pumps in a gram-flow reactor to form a combined solution, adding deionized water with a continuous flow-pump to the combined solution to form a liquid-organic phase solution, extracting the organic phase from the solution and treating with a solution of t-butyl nitrite with a continuous flow pump in a gram flow reactor to form lomustine.

Abstract: A steering column may include a casing tube in which a steering spindle is rotatably mounted, a guide unit that receives the casing unit so as to be telescopically adjustable in a direction of a longitudinal axis, and an electromotor adjustment drive that is arranged between the casing tube and the guide unit. An inner bearing face of the guide unit surrounds an outer casing surface of the casing tube and includes a slot extending longitudinally with a slot width between mutually opposing slot edges. A preload device engages the slot edges and is configured to apply a tightening force to reduce the slot width to preload the bearing face together with the casing surface. A clamping body cooperates with the slot edges via a deflection device that converts a reduction of slot width into a radial clamping movement of the clamping body for radial preloading the outer casing surface.

Abstract: A steering column includes an outer jacket that is adjustably secured to a carrier unit and clamped to a telescopically adjustable inner jacket. The outer jacket has a tubular body with a clamping slot extending longitudinally. Opposing side plates disposed alongside the clamping slot extend longitudinally. The side plates are connected to the tubular body and each have a longitudinally-extending elongated hole spaced apart from the tubular body in an outer region that protrudes from the tubular body. A clamping bolt extends through the elongated holes and an opening of the carrier unit. The clamping bolt applies a clamping force to load the side plates. An inner region of each side plate is fixed to the tubular body. A support element is connected to each side plate between the elongated hole and the inner region and is connected to the tubular body in an edge region of the clamping slot.

Abstract: A steering column includes an adjusting unit that is fixedly clampable releasably to a supporting unit and in which a steering spindle is mounted rotatably about a longitudinal axis, a clamping device with a release position and a fixing position for locking the adjusting unit to the supporting unit, a clamping bolt arranged along a clamping axis and guided transversely with respect to the longitudinal axis through an elongated hole in the supporting unit extending in an adjustment direction and in which the clamping bolt in the release position is movable. A fixing element on the clamping bolt can be braced by the clamping device in the direction of the clamping axis against the supporting unit. A guide device may have guide elements on the fixing element and on the supporting unit that are spaced apart from the elongated hole, the fixing element being guided in the guide elements in a translational manner relative to the supporting unit.

Abstract: A steering column has an actuating unit and retaining unit. A clamping device includes a clamping lever and a clamping shaft which are rotationally coupled and the clamping shaft has a cam which is connected to the clamping shaft in a rotationally fixed manner. A fixing device includes an arresting element and is arranged in the retaining unit. An engagement element is connected to the actuating unit. The cam and a guide track of the arresting element such that the arresting element can be brought into engagement with the engagement element by a rotary movement of the cam. The guide track has a first ramp region, a second ramp region and, situated therebetween, a transition region starting from which the ramp regions are formed, wherein the first ramp region is designed as a rising ramp, and the second ramp region comprises a falling ramp.

Abstract: A steering column includes an adjusting unit that is fixedly clampable releasably to a supporting unit and in which a steering spindle is mounted rotatably about a longitudinal axis, a clamping device with a release position and a fixing position for locking the adjusting unit to the supporting unit, a clamping bolt arranged along a clamping axis and guided transversely with respect to the longitudinal axis through an elongated hole in the supporting unit extending in an adjustment direction and in which the clamping bolt in the release position is movable. A fixing element on the clamping bolt can be braced by the clamping device in the direction of the clamping axis against the supporting unit. A guide device may have guide elements on the fixing element and on the supporting unit that are spaced apart from the elongated hole, the fixing element being guided in the guide elements in a translational manner relative to the supporting unit.

Abstract: A steering column has an actuating unit and retaining unit. A clamping device includes a clamping lever and a clamping shaft which are rotationally coupled and the clamping shaft has a cam which is connected to the clamping shaft in a rotationally fixed manner. A fixing device includes an arresting element and is arranged in the retaining unit. An engagement element is connected to the actuating unit. The cam and a guide track of the arresting element such that the arresting element can be brought into engagement with the engagement element by a rotary movement of the cam. The guide track has a first ramp region, a second ramp region and, situated therebetween, a transition region starting from which the ramp regions are formed, wherein the first ramp region is designed as a rising ramp, and the second ramp region comprises a falling ramp.

Abstract: The invention generally relates to systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer. In certain aspects, the invention provides a system that includes a plug flow crystallizer having a channel, one or more heating/cooling elements, each operably associated with a different segment of the channel, and a controller. The controller is operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel.

Abstract: The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

Abstract: The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

Abstract: The invention generally relates to systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer. In certain aspects, the invention provides a system that includes a plug flow crystallizer having a channel, one or more heating/cooling elements, each operably associated with a different segment of the channel, and a controller. The controller is operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel.

Abstract: The object of the present invention is a process for preparing the 2-acetoxi-5-(2-fluor-?-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts from crystalline 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI). Further objects of the present invention are two novel crystalline forms of 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI) and the use thereof for preparing the compound of the formula (V) and process preparing thereof.

Abstract: The present invention is related to intermediates useful in the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid and polymorphs of said intermediates, methods for preparation thereof and use thereof.

Abstract: The present invention relates to crystalline Form I rosuvastatin zinc (2:1) salt, method of preparation thereof and use thereof as pharmaceutically active ingredient for the treatment of diseases related to lipid metabolism including hyperlipoproteinemia, hypercholesteremia, dyslipidemia and atherosclerosis.

Abstract: A method for purifying diatomaceous earth, whose natural colloidal structure is retained, which includes preparing a suspension of diatomaceous earth in a liquid wherein diatomaceous earth is insoluble, separating diatomaceous earth from the suspension, treating diatomaceous earth with an inorganic or organic acid, heat-treating the thus obtained product at a temperature not higher than 300° C., subjecting the product obtained to oxidative treatment and drying the purified product.

Abstract: The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.

Abstract: The present invention is related to intermediates useful in the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid and polymorphs of said intermediates, methods for preparation thereof and use thereof.

Abstract: The present invention is related to a method for purifying diatomaceous earth wherein the natural colloidal structure of the material is retained, which comprises preparing a suspension of diatomaceous earth in a liquid wherein diatomaceous earth is insoluble, separating diatomaceous earth from the suspension, treating diatomaceous earth with an inorganic or organic acid, heat-treating the thus obtained product at a temperature not higher than 300° C., subjecting the product obtained to oxidative treatment and drying the purified product. The invention also relates to a product obtainable by the above-mentioned method.