Abstract: An inflatable cuff having integrated ultrasound transducers is used to effect hemostasis of deep bleeding wounds in limbs. The cuff includes a chamber defined by a bladder or a series of dams into which a fluid may be introduced and pressurized. The pressure of the fluid stops or slows bleeding while high intensity focused ultrasound is applied to effect hemostasis. The fluid may also serve as an acoustic couplant between the limb and the ultrasound transducers. The transducers may be electrostrictive transducers. Diodes may be used to reduce parallel capacitive loading in the transducer array. Bypass capacitors using the electrostrictive material may also be used.

Abstract: Embodiments disclosed herein relate to a therapeutic ultrasound device spatial registration method and apparatus. The method enables locating a tissue target and surrounding tissue structures affecting the available acoustic beam paths to the target, relative to each individual therapeutic and diagnostic (e.g., imaging) transducer, in a device comprising a plurality of such transducers. By locating the target and tissue structures relative to each therapeutic transducer and/or array (e.g., in “local” coordinates) assists in transforming the locations relative to any transducers, enabling determination of which therapeutic transducers to use to treat the target, and specification of their respective ultrasound powers or energy, focal locations and beam patterns. The registration method employs a plurality of emitter and receiver acoustic sensors on, respectively, a plurality of imaging and therapeutic transducer device panels.

Abstract: A hyperthermic treatment of lung cancer in a patient and delivering therapeutic or diagnostic biological agents to airway surfaces, where preselected pulmonary air passages adjoining pulmonary tissues comprising malignant cells are temporarily filled and then heating adjoining pulmonary tissues comprising the malignant cells to a temperature in a specified range by transmitting ultrasound through the liquid-filled pulmonary passages of a specific frequency. Also disclosed is an apparatus for applying the ultrasound at the appropriate frequency to the interior surfaces of a bodily cavity for diagnostic and therapeutic treatment.

Abstract: Methods of delivering a therapeutic or diagnostic agent in a perfluorochemical liquid carrier are provided. In preferred embodiments, the disclosed methods use compositions in the form of an emulsion or a dispersion for delivery of a biological agent to the pulmonary air passages.

Abstract: Biocompatible fluorocarbon compositions are provided which may be used for the delivery of bioactive agents to the pulmonary air passages of a patient. Preferred compositions comprise a fluorocarbon liquid carrier having a bioactive agent in a solid or immiscible liquid form distributed therein. The disclosed compositions allow for the selective delivery of bioactive agents in conjunction with liquid lavage and liquid ventilation for the treatment of ARDS and other pulmonary disorders.

Abstract: An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.

Abstract: An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.

Abstract: An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.

Abstract: A hyperthermic treatment of lung cancer, by temporarily filling with a liquid medium preselected pulmonary air passages adjoining pulmonary tissues containing malignant cells, circulating exogenously heated liquid medium at from about 41.degree. to abThis invention was made with government support under Small Business Innovation Research Program Grant No. 1 R43 CA48611-01 awarded by the Public Health Service, Department of Health and Human Services. The government has certain rights in the invention.