Abstract: Embodiments of the invention provide amperometric analyte sensors having elements selected to optimize enzymatic activities associated with such sensors including polymers functionalized with enzymatic mediators as well as methods for making and using such sensors. While embodiments of the invention can be used in a variety of contexts, typical embodiments of the invention include glucose or ketone sensors used in the management of diabetes.

Abstract: Heterocyclic compounds of Formula (I) are described herein along with their stereoisomers and pharmaceutically acceptable salts thereof. The compounds described herein, their stereoisomers, and pharmaceutically acceptable salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis.

Abstract: A system and method enabling the seamless transition between viewing a recorded portion of a program and rejoining a live stream of that program. The system and method enable the rapid provision of live-streamed content upon the exhaustion of the playback of recorded content. This achieved by utilizing a universal resource locator associated with the source of the content.

Abstract: A system level scheme for networking of implantable devices, electronic patch devices/sensors coupled to the body; and wearable sensors/devices with cellular telephone/mobile devices, peripheral devices and remote servers.

Abstract: A method for creating a standby database with read/write access capability while also maintaining a data consistency with a primary database, is provided. The method includes syncing the primary database with a physical standby mirror existing on the standby database, creating a first data compartment and a second data compartment on the standby database, separate from the physical standby mirror, applying a change made to the first data object on the primary database to the corresponding first data object on the physical standby mirror; and determining whether the change should be applied to the corresponding first data object stored on the first data compartment in accordance with data merge rules associated with the first data compartment and the second data compartment.

Abstract: Techniques and architecture are described for validating and verifying iPXE scripts prior to execution during a booting process. During the booting process of a network device, right after the UEFI/BIOS stage of the booting process, a trusted iPXE script may make a request to a network server for the ownership voucher and owner certificate of the network device. The ownership voucher and owner certificate may then be stored in a trusted platform module (TPM) on the network device. In configurations, the retrieved owner certificate may be validated by the ownership voucher. The owner certificate may be used to validate iPXE scripts. Once validated, the iPXE scripts may be executed and the booting process may be continued to the kernel loading step and the application loading step. During a subsequent booting process of the network device, the ownership voucher and owner certificate may be retrieved from the TPM.

Abstract: The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

Abstract: A system level scheme for networking of implantable devices, electronic patch devices/sensors coupled to the body; and wearable sensors/devices with cellular telephone/mobile devices, peripheral devices and remote servers.

Abstract: A radar system processes signals in a flexible, adaptive manner to determine range, Doppler (velocity) and angle of objects in an environment. The radar system includes transmitters configured to transmit radio signals, receivers configured to receive radar signals, and a control unit. The received radio signals include transmitted radio signals transmitted by the transmitters and reflected from objects in an environment. The control unit adaptively controls the transmitters and the receivers based on a selected operating mode for the radar system. The selected operating mode meets a desired operational objective defined by current environmental conditions. The control unit is configured to control the receivers to produce and process data according to the selected operating mode.

Abstract: A medicine delivery and tracking system includes a medicine injection pen and a delivery port. The pen includes a needle through which medicine is dispensed and an electronic unit configured to at least one of log dispensing of medicine from the pen, control dispensing of medicine from the pen, or communicate regarding dispensing of medicine from the pen. Alternatively, the electronic unit may be part of a separate computing device. The delivery port is configured for attachment to a user and to receive the needle of the pen such that medicine dispensed from the pen is dispensed into the delivery port and through the delivery port to the user. The delivery port includes a detector mechanism configured to detect a presence of the pen and, in response thereto, to communicate a signal to the electronic unit for use in the at least one of logging, controlling, or communicating.

Abstract: According to at least one aspect, a hybrid dispenser comprising at least one hydrogen gas nozzle configured to dispense hydrogen gas to a fuel tank of a vehicle is provided. According to some aspects, the hybrid dispenser comprises one or more electrical connectors for connecting to a vehicle to exchange electrical power, and at least one controller configured to cause electrical power to be provided to a vehicle via at least one of the one or more electrical connectors in a first operating mode and cause electrical power to be received from a vehicle via at least one of the one or more electrical connectors in a second operating mode. According to some aspect, the hybrid dispenser comprising a wireless charging system and at least one controller configured to initiate operation of the wireless charging system to wirelessly charge the vehicle during a charging event.

Abstract: A system for facilitating remote reachability checks for a switch. During operation, the system can receive one or more control messages from a management platform. Here, a respective control message can include one or more type-length-value (TLV) data structures. If the system identifies a first TLV data structure associated with validation in a first control message, the system can determine a validating plane based on a value of the first TLV data structure. The system can then validate the first control message at the validating plane. Upon identifying, in a second control message, a second TLV data structure associated with a plurality of parameters for a request in the second control message, the system can determine a subset of active parameters from the plurality of parameters based on an indicator in the second TLV data structure. The system can then process the request based on the subset of active parameters.

Abstract: A system includes a plurality of wireless transmitters and a processor configured to: receive, from a mobile device, signal strengths of signals from the wireless transmitters as detected by the mobile device. The processor is also configured to determine a location of the mobile device in a vehicle, based on a distance from the mobile device to each of the wireless transmitters, as indicated by the received signal strengths and store the location of the mobile device as an occupant location.

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising an analyte modulating layer formed from acrylate hydrogel composition that modulates the diffusion of glucose through the analyte modulating layer and which further comprises a bioactive agent selected to enhance the biocompatibility of analyte sensors when implanted in vivo.

Abstract: A method for forming an insoluble adduct using an acidic medium is provided. A chemical process utilizes acidic media to change the solubility behavior of metal solutes. The method can utilize Group 1 soluble alkali metals but can also be extended to any other soluble salts discussed under the solubility rules. The insoluble salts can be Group 2 alkaline earth metals or other insoluble salts. The insoluble adduct can have the designation XYZ where X is a soluble metal from a metal hydroxide or a metal oxide, Y is an insoluble metal from an insoluble metal hydroxide or an insoluble metal oxide, and Z is the acid ion from an aqueous acidic media.

Abstract: A method for compensating for a life-lengthening agent for a glucose sensor includes accessing first and second electrochemical impedance spectroscopy (EIS) values of at least one parameter based on first and second EIS procedures performed on EIS signals from a working electrode of the glucose sensor, calculating a change in the at least one parameter between the first and second EIS values, estimating a concentration of the agent based on the change in the at least one parameter, and calculating a model effect in response to the concentration. In a case where the model effect is not greater than the threshold, the method further includes adjusting a sensor glucose value based on the concentration and sensor signals from the working electrode, and displaying the adjusted sensor glucose value.

Abstract: A radar system including a transmitter configured for installation and use with the radar system and configured to transmit radio signals. The transmitted radio signals are defined by a spreading code. The radar system also includes a receiver configured for installation and use with the radar system and configured to receive radio signals that include transmitted radio signals transmitted by the transmitter and reflected from objects in an environment. The receiver is configured to convert the received radio signals into frequency domain received samples. The receiver is also configured to correlate the frequency domain received samples to detect object distance.

Abstract: A method of implementing an artificial intelligence based imaging platform for cardiopulmonary analysis comprises providing a multilayer convolutional network for cardiopulmonary analysis configured for segmenting data sets of cardiopulmonary scans into resolution voxels; supervised learning and validation of the platform by classification of tissue within classification voxels of a specific given training and validation data sets by the multilayer convolutional network for neurological tumor identification with each classification voxel of the training and validation data sets having a predetermined ground truth; and implementing the platform by classification of tissue within classification voxels of a specific given patient data sets by the multilayer convolutional network for cardiopulmonary analysis with each classification voxel of each data set assigned a label. An artificial intelligence based imaging platform implemented according to the method is disclosed.

Abstract: In one embodiment, methods for mediated transfer of ownership are described. The method may include receiving a request for an ownership voucher from a device, validating an identifier of the device, determining whether to issue the ownership voucher, generating a signed ownership voucher, and sending the signed ownership voucher to the device. In another embodiment, methods for unmediated transfer of ownership are described, including receiving, an ownership voucher associated with a first ownership certificate, determining whether the ownership voucher comprises a signature associated with a manufacturer, based at least in part on determining that the signature of the manufacturer is absent, determining that a second ownership certificate is stored in memory, determining that the second ownership certificate comprises a signature associated with a user, validating the ownership voucher; and based at least in part on the validating, enrolling the first ownership certificate on the network device.

Abstract: Heterocyclic compounds of Formula (I), (II), and (III) are described herein along with their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof. The compounds described herein, their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cancer, cystic fibrosis, asthma, multiple sclerosis and psoriasis.