Abstract: Heterocyclic compounds of Formula (I) are described herein along with their stereoisomers and pharmaceutically acceptable salts thereof. The compounds described herein, their stereoisomers, and pharmaceutically acceptable salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis.

Abstract: Mobile device applications may be enabled to function with greater reliability and performance with greater network visibility and control over the network infrastructure. A mobile device may be enabled with multiplexing across physical and virtual network interfaces. The mobile device may communicate with a server to access specific IP cell towers with wireless to wired offload capability or access points or define a routing table across with networks including wired and wireless hop switches. The connections may be virtualized to a universal interface.

Abstract: A system includes a plurality of wireless transmitters and a processor configured to: receive, from a mobile device, signal strengths of signals from the wireless transmitters as detected by the mobile device. The processor is also configured to determine a location of the mobile device in a vehicle, based on a distance from the mobile device to each of the wireless transmitters, as indicated by the received signal strengths and store the location of the mobile device as an occupant location.

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

Abstract: A augmented reality glasses and social networking service coupled with immersive stories, pictures, and 360 video are enabled using one or more wireless communication devices, smart glasses, augmented reality devices, mobile devices, and wireless networks. Picture and video challenges are enabled to drive communication within members of the group. Users are enabled to describe presence for activity using a presence matching and monitoring subsystem. The ability to share stories with a select group of individuals is enabled. The stories may include automatically condensed highlights of an individual or group chat or acquired media. the social networking and messaging platform may have features including issuing status updates with timer clock in which it counts down, creating channels and groups based on events, location and occasions, creating stories based on specific content items from one or more users in one or more channels.

Abstract: A method and system for estimating upgrade time and mitigating errors when updating a virtualized computing system. Operations of this method include, but are not necessarily limited to the following (and not necessarily in the following order): (i) identify updates needed by a system; (ii) compare the system to be updated to other systems to determine similar systems that already had the similar updates; (iii) project the time to complete the update based on the performance characteristics of the system to be updated, the performance characteristics of the similar systems that have already been updated, and the time taken to update the similar systems; (iv) identify errors that occurred when updating the similar systems and the corresponding error resolutions; and (v) pre-emptively apply configuration changes or other error resolutions to the system to be updated.

Abstract: Techniques and architecture are described for providing a configurable security posture for a network device using an extended ownership artifact, e.g., an ownership voucher, an ownership certificate, etc., and a security profile mechanism that scales to user needs and desires for security profiles on network devices, i.e., easily and securely customizable on thousands of nodes of a network. The configurable security posture may be achieved using the manufacturer authorized signing authority (MASA) to issue an ownership voucher with a security bit extension to support security profile additions. Using the MASA service, a user may explicitly decide on various security postures of a given network device and may apply that profile across the fixed or modular chassis of a network of network devices.

Abstract: An artificial intelligence based vascular mapping and interventional procedure assisting platform configured to identify at least the femoral artery and the bifurcation point of the femoral artery of a patient based upon dynamic imaging of the patient. The platform may be a stroke management tool in which an angiogram and conventional bloodwork can be inputted into the platform and the platform provides one of i) classification of a stroke and stroke prediction; and whether an interventional procedure is indicated and wherein if interventional procedure is indicated then vascular mapping is provided with bifurcation points and the desired access illustrated together with a listing of accepted or counter indicated closure systems that may be used.

Abstract: A system includes a plurality of wireless transmitters and a processor configured to: receive, from a mobile device, signal strengths of signals from the wireless transmitters as detected by the mobile device. The processor is also configured to determine a location of the mobile device in a vehicle, based on a distance from the mobile device to each of the wireless transmitters, as indicated by the received signal strengths and store the location of the mobile device as an occupant location.

Abstract: A system level scheme for networking of implantable devices, electronic patch devices/sensors coupled to the body; and wearable sensors/devices with cellular telephone/mobile devices, peripheral devices and remote servers.

Abstract: Techniques and architecture are described for providing a configurable security posture for a network device using an extended ownership artifact, e.g., an ownership voucher, an ownership certificate, etc., and a security profile mechanism that scales to user needs and desires for security profiles on network devices, i.e., easily and securely customizable on thousands of nodes of a network. The configurable security posture may be achieved using the manufacturer authorized signing authority (MASA) to issue an ownership voucher with a security bit extension to support security profile additions. Using the MASA service, a user may explicitly decide on various security postures of a given network device and may apply that profile across the fixed or modular chassis of a network of network devices.

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

Abstract: Windows including sunroofs of a car may be enabled to display cinematic video, still pictures, opaque content, or picturesque content such as the countryside to simulate various environments while driving. On the outside of the autonomous vehicle advertising content may be shown on digital displays to pedestrians, bystanders, and other vehicle, autonomous vehicle or semi-autonomous vehicle passengers. Advertising revenue may offset vehicle leasing, maintenance, fuel, and ridesharing costs. Ad networks may send local offers content for presentation on the vehicle, autonomous vehicle or semi-autonomous vehicle's windows. Passengers may order food and interact with ads on the car window. The car windows may be multi-touch enabled to allow for various gestures and interactivity with the vehicle, autonomous vehicle or semi-autonomous vehicle. A ridesharing program may allow a passenger to enable ads on the window of the car during their trip to defray the cost of the trip.

Abstract: A number of variations which may include a product including a combustion engine cylinder block having a first snap channel having first multi-radii fillet profile, and methods of making the same.

Abstract: A mobile communication system based on digital content including images and video that may be acquired, processed, and displayed using a plurality of mobile devices, smartphones, tablet computers, stationary computers, intelligent electronic glasses, and servers.

Abstract: Embodiments of the invention provide amperometric analyte sensors having membranes made from materials selected to transport analytes such as glucose to an enzyme within the sensor while simultaneously inhibiting the movement of interfering species such as acetaminophen to the electrode within the sensor. While embodiments of the invention can be used in a variety of contexts, typical embodiments of the invention include glucose or ketone sensors used in the management of diabetes.

Abstract: A system for facilitating remote reachability checks for a switch. During operation, the system can receive one or more control messages from a management platform. Here, a respective control message can include one or more type-length-value (TLV) data structures. If the system identifies a first TLV data structure associated with validation in a first control message, the system can determine a validating plane based on a value of the first TLV data structure. The system can then validate the first control message at the validating plane. Upon identifying, in a second control message, a second TLV data structure associated with a plurality of parameters for a request in the second control message, the system can determine a subset of active parameters from the plurality of parameters based on an indicator in the second TLV data structure. The system can then process the request based on the subset of active parameters.

Abstract: Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes, and associated architectures, as well as methods for making and using such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract: An augmented navigational system is provided for autonomous vehicles. The augmented navigational system may further be coupled to an artificial intelligence system that provides object recognition and image recognition. A machine learning system may provide further feedback as to whether the pickup and drop off location was appropriate, and whether the recognition of one or more objects was appropriate.