Abstract: There is provided crystalline solvate forms of Warfarin potassium, termed APO-I and APO-II, and processes for making APO-I and APO-II. APO-I and APO-II are polymorphic solvate forms of Warfarin potassium.

Abstract: There is provided crystalline solvate forms of Warfarin potassium, termed APO-I and APO-II, and processes for making APO-I and APO-II. APO-I and APO-II are polymorphic solvate forms of Warfarin potassium.

Abstract: The present invention relates to a new and useful amorphous form of ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride) and preparations thereof.

Abstract: A process for the preparation of aminoalkyl phenyl carbamate compounds of Formula I, wherein R1 and R2 independently are hydrogen or a C1-6 alkyl; R3 and R4 are the same or different and each is a C1-6 alkyl; or R3 and R4 together with the nitrogen to which they are attached form a cyclic three to eight membered ring, with or without a heteroatom like nitrogen or oxygen; R5 and R6 independently are hydrogen, linear, branched or cyclic C1-6 alkyl; or R5 and R6 together with the nitrogen to which they are attached form a cyclic three to eight membered ring, with or without a heteroatom like nitrogen or oxygen; the carbon centre designated “*” can be racemic or enantiomerically enriched in the (R)— or (S)-configuration; and pharmaceutically acceptable acid addition salts thereof.

Abstract: A process for the preparation of an acid addition salt of ziprasidone base and intermediates thereof comprising exposing the ziprasidone base in solid form to a gaseous acid in a substantially dry environment.

Abstract: A process for the preparation of an acid addition salt of an organic base comprising exposing the organic base in solid form to a gaseous acid, with the proviso that ziprasidone, its acid addition salts and intermediates thereof are excluded.

Abstract: A process for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester comprising: (a) reduction of 5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-oxo-1-pentanoic acid, (R)-2-hydroxy-1,2,2-triphenylethyl ester; (b) hydrolysis of (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid, (R)-2-hydroxy-1,2,2-triphenylethyl ester using an alkali base in a solvent to form the acid; (c) alkylation of the acid forming (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester.

Abstract: A process for the resolution of each of the enantiomers of methyl-?-5-[4,5,6,7-tetrahydro[3,2-c]thienopyridyl]-(2-chlorophenyl)acetate and salts thereof by diastereomeric crystallization comprising the use of a single optically active resolving agent and at least one solvent.

Abstract: A process for the preparation of amorphous atorvastatin calcium and hydrates thereof, which comprises: (a) hydrolysis of the precursor lactone using sodium hydroxide to form atorvastatin sodium salt solution; (b) addition of the atorvastatin sodium salt solution to a calcium chloride or calcium acetate solution in the absence or presence of seeds of amorphous atorvastatin calcium; and (c) isolation of the resultant amorphous atorvastatin calcium salt by filtration and drying.

Abstract: A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: ##STR1##

Abstract: An improved process for the production of methyl ethers of the type in which methanol is reacted with a branched monoolefin in the presence of a catalytically effective amount of one or more acid catalyst, said improvements comprising carrying out said reaction in one or two steps in the presence of one or more liquid organic compounds having one or more hydroxy substituents which functions as a carrier for the branched monoolefins. The hydroxy compound also inhibits the polymerization of the branched monoolefins.

Abstract: A process for converting heavy hydrocarbons into light hydrocarbons which comprises contacting, in a reaction zone, a heavy hydrocarbon having an API gravity at 25.degree. C. of less than about 20, such as Boscan heavy crude oil or tar sand bitumen, with a liquid comprising water and with an effective amount of selected catalyst materials such as iron (II and/or III) oxides, sulfides or sulfates, in the absence of externally added hydrogen, at a temperature between greater than about 340.degree. and about 480.degree. C. and at a pressure between about 1350 kPa (about 196 psig, about 13.2 atm) and about 15,000 kPa (about 2175 psig, about 148 atm), for a time sufficient to produce a residue and a vapor phase comprising light hydrocarbons, gaseous product and water, withdrawing the residue and said phase from the second zone; and recovering a light hydrocarbon product having an API gravity at 25.degree. C. of greater than about 20 and substantially free of vanadium and nickel values, i.e.

Abstract: A process of depositing thin film onto a substrate using super-critical fluids.

Abstract: An improved process for the production of methyl ethers of the type in which methanol is reacted with a branched monoolefin in the presence of a catalytically effective amount of one or more acid catalyst, said improvements comprising carrying out said reaction in one or two steps in the presence of one or more liquid organic compounds having one or more hydroxy substituents which functions as a carrier for the branched monoolefins. The hydroxy compound also inhibits the polymerization of the branched monoolefins.

Abstract: A novel process is described for the production of aliphatic ketones and an optional consequetive production of the corresponding carbinols. The starting reactants comprise ketones or aldehydes or compounds capable of converting to these in situ, such as alcohols. The reaction takes place in the presence of hydrogen in a selective temperature range, utilizing a catalyst comprising copper oxide.

Abstract: A process for converting heavy hydrocarbon into light hydrocarbon which comprises contacting heavy hydrocarbon having an API gravity at 25.degree. C. of less than about 20, such as Boscan heavy crude oil and tar sand bitumen, with a liquid comprising water, and carbon monoxide in the presence of an externally added catalyst comprising a mixture of sulfur and at least one of ferric oxide, ferric sulfide, ferrous sulfide and pyrite a residue and a phase comprising light hydrocarbon, gas and water; separating the residue and said phase; and recovering from said phase light hydrocarbon having an API gravity at 25.degree. C. of greater than about 20, and having a hydrogen to carbon mole ratio greater than that of the heavy hydrocarbon feedstock.

Abstract: A process is disclosed for converting heavy hydrocarbons into light hydrocarbons which comprises contacting, in a first zone, a heavy hydrocarbon having an API gravity at 25.degree. C. of less than about 20, such as Boscan heavy crude oil and tar sand bitumen, with a liquid comprising water, in the absence of externally added catalyst and hydrogen, while maintaining the first zone at a temperature between 400.degree. and about 480.degree. C. and at a pressure at least about 690 kPa (about 100 psig, about 6.76 atm) and less than about 5,000 kPa (about 725 psig, about 148 atm), for a contact time under continuous flow conditions sufficient to produce a uniform (i.e.

Abstract: Methanol is reacted with branched monoolefins such as isobutylene, or mixtures of hydrocarbons such as mixed C-4's from or in a refinery, in the presence of methanesulfonic acid. A column (10) operation is described wherein methanesulfonic acid (11) and methanol (12) are fed in countercurrent fashion to hydrocarbons (13). Crude product ether is removed as a liquid sidestream (25) above the feed of methanesulfonic acid (11), while hydrocarbons depleted of the reactive branched monoolefins (24) are removed overhead. The methanesulfonic acid suppresses the vapor pressure of methanol relative to product ether.

Abstract: A process for converting heavy hydrocarbons into light hydrocarbons which comprises contacting, in a first zone, a heavy hydrocarbon having an API gravity at 25.degree. C. of less than about 20, such as Boscan heavy crude oil and tar sand bitumen, with a liquid comprising water, in the absence of externally added catalyst and hydrogen, while maintaining the first zone at a temperature between about 380.degree. and about 480.degree. C. and at a pressure between about 5000 kPa (about 725 psig, about 49 atm) and about 15,000 kPa (about 2175 psig, about 148 atm), for a time sufficient to produce a uniform reaction mixture; forwarding the uniform reaction mixture to a second zone wherein the temperature and pressure conditions of the first zone are maintained for a time sufficient to separate the uniform mixture into a residue and a phase comprising light hydrocarbons, gas and water, withdrawing the residue and said phase from the second zone; and recovering a light hydrocarbon product having an API gravity at 25.