Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

Abstract: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

Abstract: This document provides natriuretic polypeptide delivery systems. For example, methods and materials related to natriuretic polypeptide delivery systems, methods and materials related to the use of such delivery systems to deliver natriuretic polypeptides to a mammal over a pro-longed period of time (e.g., weeks to months), and methods and materials related to treating heart failure conditions are provided.

Abstract: Methods and media for analyzing electrical designs are provided. A method includes and the media are configured for providing or loading to an analysis tool a design that includes a plurality of cell instances of a standard cell and estimating a failure rate of the design using in context electrical parameters for the plurality of cell instances and a parameterized electromigration (EM) view of the standard cell. Another method includes providing a standard cell of a standard cell library and characterizing the standard cell to create a parameterized thermal model to compute a temperature of an internal structure of the standard cell and a parameterized current model to compute a current through the internal structure of the standard cell given in context electrical parameters.

Abstract: Method, apparatus and system embodiments to assign priority to a thread when the thread is otherwise unable to proceed with instruction retirement. For at least one embodiment, the thread is one of a plurality of active threads in a multiprocessor system that includes memory livelock breaker logic and/or starvation avoidance logic. Other embodiments are also described and claimed.

Abstract: In a multithreaded processor, the efficiency of instruction processing may be improved by suspending an executing thread during the translation of a virtual memory address to a physical memory address when the address translation data must be retrieved from storage external to the processor. The suspension of an executing thread allows an address translation to be performed for an instruction in another thread while the address translation data needed for the first thread is retrieved.