Patents by Inventor Ka-Ram Kim

Ka-Ram Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240255410
    Abstract: The present invention provides a cell measurement device and method in which retroreflective particles are introduced to measure cells, and thus, an optical signal is obtained without fixing of life activity of cells and performing a separate staining process. An example of the use of retroreflection-based cytometry is evaluation of cell migration. The cells capture the retroreflective particles during cell migration or growth, and migrate in a state that the particles are captured in the cell or bind to the cells. The migrated cells are observed in a form of bright dots inside the cells under irradiation of white light as a non-spectroscopic light source to the cells in the retroreflective optical system. The number of bright spots is counted, and thus, the number of cells and the presence thereof thus can be easily measured based on an image.
    Type: Application
    Filed: July 28, 2021
    Publication date: August 1, 2024
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Hyun Chul YOON, Jae-Ho KIM, Ka Ram KIM
  • Patent number: 12007327
    Abstract: An optical bio-sensing device includes a transparent substrate covering a top of a space accommodating therein a sample containing a target bio-material; a signal converter fixed to the transparent substrate, and including the upconversion nanoparticles for receiving incident light and emitting converted light of a wavelength shorter than a wavelength of the incident light; a signal reflector including retroreflection particles bindable to the signal converter via the target bio-material, wherein the retroreflection particles retroreflect the converted light; a light source for irradiating the incident light to the signal converter; and a light receiver for receiving light retroreflected from the signal reflector.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: June 11, 2024
    Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Hyun C Yoon, Ka Ram Kim, Hyeong Jin Chun
  • Publication number: 20240125698
    Abstract: A gadget for retroreflected signal measurement is disclosed. The gadget for measuring the retroreflected signal includes a partitioning wall; a portable terminal receiving portion disposed on one surface of the partitioning wall; a biosensor receiving portion disposed on the other surface of the partitioning wall and constructed to receive a biosensor therein; a light exit channel defined in the partitioning wall and at one side thereof; and a light-receiving channel adjacent to the light exit channel and defined in the partitioning wall, wherein light passes through the light exit channel and then is reflected from the biosensor, and then is incident into the light-receiving channel.
    Type: Application
    Filed: February 10, 2022
    Publication date: April 18, 2024
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Hyun Chul YOON, Ka Ram KIM, Kyung Wom LEE, Jae-ho KIM
  • Publication number: 20240058260
    Abstract: According to an exemplary embodiment of the present disclosure, a cosmetic composition comprising a fermented grape extract obtained by fermenting grape (Vitis vinifera) berries using fungus of the genus Botrytis is disclosed.
    Type: Application
    Filed: September 24, 2021
    Publication date: February 22, 2024
    Applicants: Korea Institute of Dermatological Science Inc, COSTORY CO., LTD
    Inventors: In Sook AN, Ka Ram KIM, Ye Eun JOO, Sang Jae SON, Shang Hun SHIN, Han Kyun KIM
  • Publication number: 20220334105
    Abstract: A bio-substance analysis method using a sensing substrate having a fluid channel is disclosed. The method includes mixing retroreflective particles with a detection solution containing a target bio-substance, wherein a first bio-recognition substance selectively reacting with the target bio-substance is modified on the retroreflective particles; placing the sensing substrate so that a bottom is located under a cover in a direction of gravity; injecting the detection solution containing therein the retroreflective particles into a fluid channel and maintaining the solution in the channel for a first time duration; turning the sensing substrate upside down so that the bottom is located above the cover in the direction of gravity and maintaining the sensing substrate in the turned state for a second time duration; irradiating light into the fluid channel through the bottom; and generating and analyzing an image based on light retroreflected from the retroreflective particles.
    Type: Application
    Filed: November 26, 2019
    Publication date: October 20, 2022
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Hyun Chul YOON, Ka Ram KIM, Hyeong Jin CHUN, Jae Ho KIM
  • Publication number: 20210262935
    Abstract: An optical bio-sensing device includes a transparent substrate covering a top of a space accommodating therein a sample containing a target bio-material; a signal converter fixed to the transparent substrate, and including the upconversion nanoparticles for receiving incident light and emitting converted light of a wavelength shorter than a wavelength of the incident light; a signal reflector including retroreflection particles bindable to the signal converter via the target bio-material, wherein the retroreflection particles retroreflect the converted light; a light source for irradiating the incident light to the signal converter; and a light receiver for receiving light retroreflected from the signal reflector.
    Type: Application
    Filed: February 11, 2021
    Publication date: August 26, 2021
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Hyun C YOON, Ka Ram KIM, Hyeong Jin CHUN
  • Publication number: 20210002546
    Abstract: Disclosed is a method of manufacturing lanthanide fluorescent silica nanoparticles, including a complex synthesis step of synthesizing a silane-lanthanide chelate complex, an emulsion formation step of forming a water-in-oil microemulsion by dispersing micelles, the water-phase core of which is introduced with the silane-lanthanide chelate complex, in an oil-phase solvent, a silica introduction step of introducing a silica precursor into the microemulsion, and a nanoparticle synthesis step of synthesizing fluorescent silica nanoparticles by crosslinking the silica precursor and the silane-lanthanide chelate complex in the micelles. The lanthanide fluorescent silica nanoparticles thus manufactured can be utilized in fluorescence analysis of inorganic materials or bio-derived materials.
    Type: Application
    Filed: February 14, 2017
    Publication date: January 7, 2021
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Hyun C. YOON, Ka Ram KIM, Yong Duk HAN, Yoo Min PARK, Hyeong Jin CHUN
  • Publication number: 20160067522
    Abstract: The present disclosure relates to a method for skin improvement using low-dose radiation, and the low-dose radiation can exhibit excellent effects of improving skin wrinkles, improving skin barriers, improving skin thickness, improving skin elasticity, and improving skin moisture through the mechanisms of promoting the growth of normal human dermal fibroblasts, increasing the collagen synthesis within the normal human dermal fibroblast, or reducing the metalloproteinase synthesis within the normal human dermal fibroblasts, thus being effectively used for skin improvement. Additionally, the low-dose radiation of the present disclosure can exhibit excellent hair growth-promoting effect through the mechanisms of promoting the growth of human dermal papilla cells or activating hair follicle cells, thus being useful for the improvement of promoting hair growth.
    Type: Application
    Filed: August 28, 2015
    Publication date: March 10, 2016
    Inventors: SUNG-KWAN AN, Seung-Hee Bae, Hwa-Jun Cha, Ka-Ram Kim, Sang-Hun Shin, Hyun-Hee Jang