Abstract: The present invention provides cell populations enriched for specific neural precursor markers and methods of using such cell populations for treatment of disorders associated with dysregulation of inhibitory neuronal function and/or imbalances in excitatory/inhibitory neuronal activity. In particular, the present invention provides cell populations for use as a cell-based therapeutic, and methods for purification and use of these neural precursor cells in transplantation to ameliorate neural disorders associated with aberrant neural function.

Abstract: A low jitter, high phase resolution phase lock loop incorporating a ring oscillator-type VCO is designed and constructed to operate at a characteristic frequency M times higher than a required output clock frequency. Multi-phase output signals are taken from the VCO and selected through a Gray code MUX, prior to being divided down to the output clock frequency by a divide-by-M frequency divider circuit. Operating the VCO at frequencies in excess of the output clock frequency, allows jitter to be averaged across a timing cycle M and further allows a reduction in the number of output phase taps, by a scale factor M, without reducing the phase resolution or granularity of the output signal.