Abstract: A process of forming a non-optically detectable authentication marking (210,320, 410,535) in a diamond (200,300). Authentication marking (210,320,410,535) is formed adjacent the outer surface of an article formed from a diamond material having intrinsic optical centers. Method includes the step of applying an image of predesigned authentication marking (210,320,410,535) to a region (201,310,530) of a diamond (200,300) at or adjacent the surface of the diamond (200,300) by way of a direct laser writing; wherein the fluorescence background of the diamond material from intrinsic optical center is suppressed by authentication marking (210,320, 410, 535) under fluorescent imaging, such that the non-optically detectable identifiable authentication marking (210,320,410,535) is viewable against the fluorescence background at the region (201,310,530) of the diamond (200,300) where the authentication marking (210,320,410,535) is applied.

Abstract: The present disclosure describes a multi-analyte sensor system. The system includes a first sensor with a first enzyme for a first analyte, a second sensor with a second enzyme for a second analyte different from the first analyte, a potentiostat, a memory, and a processor communicatively coupled to the memory. The potentiostat applies a first voltage to the first sensor to cause a first current to flow through the first sensor and applies a second voltage to the second sensor to cause a second current to flow through the second sensor. The processor determines, based on the first current, a level of the first analyte and determines, based on the second current, a level of the second analyte.

Abstract: The present disclosure describes a multi-analyte sensor system that detects wear location. The system includes a first sensor, a second sensor, a memory, and a processor communicatively coupled to the memory. The first sensor produces a first signal stream indicating a level of a first analyte, and the second sensor produces first physiological data. The processor determines, based on the first signal stream and the first physiological data, a wear location of the first sensor and makes an adjustment related to at least one of the first sensor or the first signal stream based on the wear location of the first sensor.

Abstract: The present disclosure describes a multi-analyte sensor system that detects artifacts using multiple analytes. According to an embodiment, the multi-analyte sensor system includes a first analyte sensor, a second analyte sensor, and a sensor electronics module. The first analyte sensor produces a first analyte signal stream indicating a level of a first analyte. The second analyte sensor produces a second analyte signal stream indicating a level of a second analyte different from the first analyte. The sensor electronics module detects, based on the first analyte signal stream and the second analyte signal stream, at least one of a compression event or a dip and recover event and in response to detecting at least one of the compression event or the dip and recover event, make an adjustment related to at least one of the first analyte sensor or the first analyte signal stream based on the event.

Abstract: A process of forming a non-optically detectable authentication marking (110), includes the step of: applying a marking at a surface of a diamond (200) using a focused ion beam (FIB) writing process so as to provide a non-optically detectable authentication marking (110) which is formed by alteration in the optical characteristics of a portion of the diamond material at the outer surface of the diamond to form a marked portion; wherein the marking is optically invisible, and wherein the marking is viewable by an imaging method which provides an observable contrast between the portion of the diamond having altered optical characteristics and the non-marked portion of the diamond. The marking process can assist in the prevention of the counterfeiting of precious articles, and be of assistance in the incident of theft. A marking, a diamond, a process of viewing a marking on a diamond are further disclosed.

Abstract: A process for determining the type of a diamond having spin properties and physical properties, said process including the steps of: (i) determining the spin properties of a diamond of unknown type, using optically detected magnetic resonance to measure the spin properties of said diamond of an unknown type, wherein the spin properties are indicative of the physical properties of the diamond; (ii) comparing the spin properties of said unknown diamond with the spin properties of a plurality of diamonds of known types; and (iii) determining the type of said diamond of unknown type upon a predetermined threshold of correlation between the spin properties of said diamond of unknown type with the spin properties of a diamond of known type of said plurality of diamonds known types.

Abstract: A process for determining the type of a diamond having spin properties and physical properties, said process including the steps of: (i) determining the spin properties of a diamond of unknown type, using optically detected magnetic resonance to measure the spin properties of said diamond of an unknown type, wherein the spin properties are indicative of the physical properties of the diamond; (ii) comparing the spin properties of said unknown diamond with the spin properties of a plurality of diamonds of known types; and (iii) determining the type of said diamond of unknown type upon a predetermined threshold of correlation between the spin properties of said diamond of unknown type with the spin properties of a diamond of known type of said plurality of diamonds known types.

Abstract: A process operable using a computerized system (300) grades the clarity of a diamond (315, 400) as a function of internal defects within its body (315, 400). The computerized system (300) includes an optical image acquisition device (310), a processor module (320) and an output module (340) operably interconnected together. The process includes the steps of (i) acquiring via an optical image acquisition device (310) a plurality of top view images of a diamond (315, 400); (ii) in a processor module (320), detecting defects within the body of the diamond (315, 400); and (iii) from an output module (340), providing a signal indicative of the clarity grade assigned in (ii).

Abstract: An apparatus includes an analyte sensor, a memory, and a processor. The processor monitors, using the analyte sensor, an analyte of a patient during a time period to obtain measured analyte data for the analyte and monitors other measured sensor data indicative of a physiological state of the patient during the time period. The processor also determines, based on the physiological state of the patient during the time period, expected analyte data for the analyte and determines a correction factor based on the expected analyte data and the measured analyte data. The correction factor is indicative of an error in calibration of the analyte sensor. The processor also determines whether recalibration of the analyte sensor is possible. If recalibration is possible, the processor recalibrates the analyte sensor based on the correction factor, and if recalibration is not possible, the processor recommends, to the patient, to replace the analyte sensor.

Abstract: A process of forming a non-optically detectable authentication marking (210,320, 410,535) in a diamond (200,300). Authentication marking (210,320,410,535) is formed adjacent the outer surface of an article formed from a diamond material having intrinsic optical centers. Method includes the step of applying an image of predesigned authentication marking(210,320,410,535) to a region (201,310,530) of a diamond (200,300) at or adjacent the surface of the diamond (200,300) by way of a direct laser writing; wherein the fluorescence background of the diamond material from intrinsic optical center is suppressed by authentication marking(210,320, 410, 535) under fluorescent imaging, such that the non-optically detectable identifiable authentication marking (210,320,410,535) is viewable against the fluorescence background at the region (201,310,530) of the diamond (200,300) where the authentication marking (210,320,410,535) is applied.

Abstract: A system (100) for viewing and ascertaining optical characteristics of gemstones, said system including a first and second integrating sphere (150,150a), wherein each integrating sphere (150,150a) is in optical communication with each other and having a spacer portion (116) disposed therebetween, a first light source (118) engaged with the first sphere (150) and for providing light to the interior of the first sphere (150) and a second light source (118a) engaged with the second sphere (150a) and for providing light to the interior of the second sphere (150a); at least one optical image acquisition device (110) in communication with the interior of one of the spheres for acquisition of an optical image of a gemstone disposed in a region between the spheres; a transparent platform (117) for supporting the gemstone between the two integrating spheres (150,150a); and a control module (120) in communication with the optical image acquisition device (110), for controlling the acquisition of optical images of gemst

Abstract: A process of forming a non-optically detectable authentication marking (110), includes the step of: applying a marking at a surface of a diamond (200) using a focused ion beam (FIB) writing process so as to provide a non-optically detectable authentication marking (110) which is formed by alteration in the optical characteristics of a portion of the diamond material at the outer surface of the diamond to form a marked portion; wherein the marking is optically invisible, and wherein the marking is viewable by an imaging method which provides an observable contrast between the portion of the diamond having altered optical characteristics and the non-marked portion of the diamond. The marking process can assist in the prevention of the counterfeiting of precious articles, and be of assistance in the incident of theft. A marking, a diamond, a process of viewing a marking on a diamond are further disclosed.

Abstract: A process for determining the type of a diamond, wherein the type of diamond is determined by the steps of (i) measuring the fluorescence lifetime characteristics of colour centres of a diamond of unknown type (110a); and (ii) determining the type of diamond by comparing the fluorescence lifetime characteristics measured at step (i) with the fluorescence lifetime characteristics of colour centres of known diamond types (120a), wherein the fluorescence lifetime characteristics of colour centres are indicative of the physical properties of a diamond, which are indicative of the type of a diamond.

Abstract: A process of determining the type of a diamond of unknown type, said process including the steps of (i) applying a laser input signal to a diamond of unknown type such the NV? centres or other C centres such that fluorescence is generated from said diamond; (ii) applying a magnetic field to said diamond and applying a variable microwave frequency to said diamond; (iii) acquiring the light intensity of fluorescence as a function of microwave frequency; and (iv) determining the type of the unknown diamond by comparing the light intensity of fluorescence as a function of microwave frequency of (iii) with light intensity versus microwave frequency characteristics diamond of known of a plurality of diamonds known types.

Abstract: A process for enhancing polarization of 13C for subsequence MRI imaging, the process comprising providing a suspension consisting of a first plurality of particulates having NV centers and a second plurality of particulates for providing internal reflection of light with wavelength for the excitement of NV centers and 13C; and applying light, magnetic field and microwave to said suspension, such that the NV centers are polarized and such that the electron spins of the VN centres are transferred to 13C atoms upon the Rabi frequency of the NV centres matching the Larmor frequency of 13C; wherein the particulates of the second plurality reflect and transmit the light through the suspension such that said light is distributed through said suspension.

Abstract: A process is operable using a computerized system for grading the colour of a diamond using a pre-trained neural network for determination of a colour grading. The computerized system includes an optical image acquisition device, a pre-trained neural network and an output module operably interconnected together via a communication link. The process includes: (i) acquiring via an optical image acquisition device one or more optical image of at least a portion of a diamond; and (ii) in a pre-trained neural network, providing a regressive value associated with the colour grade of the diamond.

Abstract: A system (100) for viewing and ascertaining optical characteristics of gemstones, said system including a first and second integrating sphere (150,150a), wherein each integrating sphere (150,150a) is in optical communication with each other and having a spacer portion (116) disposed therebetween, a first light source (118) engaged with the first sphere (150) and for providing light to the interior of the first sphere (150) and a second light source (118a) engaged with the second sphere (150a) and for providing light to the interior of the second sphere (150a); at least one optical image acquisition device (110) in communication with the interior of one of the spheres for acquisition of an optical image of a gemstone disposed in a region between the spheres; a transparent platform (117) for supporting the gemstone between the two integrating spheres (150,150a); and a control module (120) in communication with the optical image acquisition device (110), for controlling the acquisition of optical images of gemst

Abstract: A conjugate (110) comprising a nanoparticle (210) for delivery of a drug to a treatment site in the body of a subject; a drug molecule (220) releasably linked to said nanoparticle (210), wherein said drug molecule (220) has a therapeutic effect at the treatment site in the body of the subject; and a disease targeting molecule (230) releasably linked to said nanoparticle (210); wherein upon said conjugate (110) being adjacent diseased tissue (240) of a subject, said disease targeting molecule (230) retains the conjugate (110) adjacent said diseased tissue (240); said drug molecule (220) is released from said nanoparticle (110) so as to provide a therapeutic effect to said diseased tissue (240); and said disease targeting molecule (230) is subsequently released from said nanoparticle (210) such that retention of the nanoparticle (210) is released, and such that the nanoparticle (210) is dispersible from said diseased tissue (240).

Abstract: A process operable using a computerized system (300) grades the clarity of a diamond (315, 400) as a function of internal defects within its body (315, 400). The computerized system (300) includes an optical image acquisition device (310), a processor module (320) and an output module (340) operably interconnected together. The process includes the steps of (i) acquiring via an optical image acquisition device (310) a plurality of top view images of a diamond (315, 400); (ii) in a processor module (320), detecting defects within the body of the diamond (315, 400); and (iii) from an output module (340), providing a signal indicative of the clarity grade assigned in (ii).

Abstract: A process is operable using a computerized system for grading the clarity of a diamond. The computerized system includes an optical image acquisition device, a processor, a pre-trained neural network and an output module operably interconnected together. The process includes: (i) acquiring via an optical image acquisition device one or more plural axial view images of a diamond with different focus depths; (ii) in a processor, combining the plural axial views to form one or more single optical images; (iii) in a pre-trained neural network, providing a regressive value associated with the clarity grade of the diamond based on the one or more single images acquired during step (i); and (iv) from an output module, providing a clarity grade to the diamond (i) by correlating the regression value from (ii) to a clarity grade.