Abstract: Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.

Abstract: An exercise method and apparatus for ensuring the completion of a predetermined number of steps each day as part of an exercise routine by integrating steps taken during a normal daily routine with steps taken on a treadmill or stepper machine.

Abstract: A method of increasing cellular NADPH levels by expressing one or more genes that encode a enzyme that causes the production of NADPH. The system can be combined with other enzymes that require NADPH, thus improving the overall production of the desired protein.

Abstract: Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.

Abstract: The invention relates to increasing the yield of succinate in bacteria by increasing the intracellular availability of cofactors such as NADH.

Abstract: Methods of increasing the cellular pool of A-CoA and thus driving the metabolic pathways in the direction of A-CoA containing metabolites by overexpressing rate limiting enzymes in A-CoA synthesis. Methods of increasing intracellular levels of CoA and A-CoA through genetic engineering of bacterial strains in conjunction with supplementation with precursor molecules.

Abstract: A four electrode bio-electrical impedance analyzer having a 45 KHz constant current pulse waveform and a synchronized detection scheme to measure the human body impedance and therefore calculate total body resistivity. The resistivity is used in conjunction with the pre-input data concerning characteristics of the person under tests to determine the percentage of body fat in a manner which is repeatable and which suppresses electrical interference.

Abstract: An improved treadmill having a weight-scale sensor and a console display which displays a history of weight loss or weight control based upon goals set over a period of time in order to facilitate an enclosed loop system for a weight loss monitoring program.

Abstract: An exercise method and apparatus for ensuring the completion of a predetermined number of steps each day as part of an exercise routine by integrating steps taken during a normal daily routine with steps taken on a treadmill or stepper machine.

Abstract: A wrist-based fitness monitoring watch which uses a lap sensing device and a step or a stroke sensing device for detecting movement. In response to the output of a micro controller, information is displayed concerning the number of laps completed, the distance completed, and the time. Also included is a wireless heart rate transfer system which is provided through the micro controller in order to provide heart rate indicators during movement of the user. The lap measurement is based on a synchronization between a heading direction from the lap sensing device and the step/stroke frequency in order to provide the lap count, as well as the distance traveled and the time. Each of these items are accomplished on a wrist based monitoring system which does not require periodic intervention by the user. The system is able to provide split times without the requiring of continual pressing of the start/stop button either before or after a running or swimming event.

Abstract: The present invention describes a novel recombinant NADH recycling system that is used as a process for producing reduced compounds. In a specific embodiment, the reduced compounds include ethanol, succinate, lactate, a vitamin, a pharmaceutical and a biodegraded organic molecule. The NADH recycling system effects metabolic flux of reductive pathways in aerobic and anaerobic environments.

Abstract: A wrist-based fitness monitoring watch which uses a lap sensing device and a step or a stroke sensing device for detecting movement. In response to the output of a micro controller, information is displayed concerning the number of laps completed, the distance completed, and the time. Also included is a wireless heart rate transfer system which is provided through the micro controller in order to provide heart rate indicators during movement of the user. The lap measurement is based on a synchronization between a heading direction from the lap sensing device and the step/stroke frequency in order to provide the lap count, as well as the distance traveled and the time. Each of these items are accomplished on a wrist based monitoring system which does not require periodic intervention by the user. The system is able to provide split times without the requiring of continual pressing of the start/stop button either before or after a running or swimming event.

Abstract: A method and apparatus for marketing and communicating in the wine/spirits industry. The method of the invention includes the steps of receiving an offer from at least one wine/spirit suppliers to pay for a solicitation to at least one identified consumer of a participating retail wine/spirit establishment for a selected set of products; communicating a set of possible product offerings from the at least one wine/spirit suppliers to at least one of the participating retailers of wine/spirits, where each such set includes a number of products; receiving a communication from at least one such participating retailer agreeing to offer a subset of said set of product offerings at a sale price; analyzing information related to such subset of such set of product offerings with a computer; and, communicating such information related to such sales of such subset of such set of product offerings to an interested party.

Abstract: An improved treadmill having a weight-scale sensor and a console display which displays a history of weight loss or weight control based upon goals set over a period of time in order to facilitate an enclosed loop system for a weight loss monitoring program.

Abstract: A fitness monitoring device, comprising a wrist-based device including a receiver and a display; a separate, remote, pedometer including pedometer step sensing circuitry and wireless transmission circuitry; and wherein said pedometer step sensing circuitry senses a user's steps and said remote pedometer wirelessly transmits a signal corresponding to said sensed steps to said wrist-based device, and further wherein said wrist-based device processes the wirelessly transmitted signal received by said receiver and controls the display.

Abstract: A multi-channel system is provided for both wide-band and narrow band low frequency transmission/reception of digital telemetry. The multi-channel system uses coherent detection having a high selectivity, and a quadrature detector having a high sensitivity. A filter is provided to average out noise. The multi-channel system oscillator is software controlled for scanning/multiplexing. The multi-channel system is used for data transmission over inductive, infrared, sonic and cable links.

Abstract: A fitness monitoring device includes an electronic pedometer which responds to a user's body motion at each step and a wireless heart rate monitor which is wirelessly coupled to the electronic pedometer. The wireless heart rate monitor provides a heart beat signal indicative of an exertion level of the user. A visual display is provided to display the pedometer functions and the heart rate signal. A microprocessor receives the pedometer output signal and the heart rate signal. The microprocessor is programmed to provide visual display data relating to the heart rate and pedometer functions.

Abstract: A synchronized voltage controlled oscillator lap counting circuit includes a bearing resolver circuit having a single Hall-effect sensor element which provides differential voltage output signals in response to an external magnetic field. The differential amplifier receives the differential voltage output signals and provides a single amplified output signal. The single amplified output signal is provided to a voltage controlled oscillator. A pedometer provides a repetitive pulsed-output signal in accordance with movements of a user. The repetitive pulsed-output signal and a voltage controlled oscillator output signal are provided to a micro-controller. The micro-controller samples the voltage controlled output signal in synchronization with the repetitive pulsed signal output from the pedometer to resolve bearing directions based on intercepted frequencies of the voltage controlled output signal.

Abstract: A circuit for resolving a magnetic field, including a first channel including a first magnetic field sensor, a first amplifier coupled to and receiving an output from said first magnetic field sensor, and a first three band detector coupled to and receiving an output from said first amplifier. The first three band detector provides a first two bit output. A second channel includes a second magnetic field sensor, a second amplifier coupled to and receiving an output from said second magnetic field sensor, and a second three band detector coupled to and receiving an output from said second amplifier. The second three band detector provides a second two bit output. The first and second magnetic field sensors are arranged orthogonally to one another such that said first and second two bit outputs resolve the magnetic field into eight bearings.