Patents by Inventor Ka-Yiu San

Ka-Yiu San has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aerobic succinate production in bacteria
    Publication number: 20060040368
    Abstract: Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.
    Type: Application
    Filed: August 9, 2005
    Publication date: February 23, 2006
    Inventors: Ka-Yiu San, George Bennett, Henry Lin
  • Increasing intracellular NADPH availability in E. coli
    Publication number: 20050196866
    Abstract: A method of increasing cellular NADPH levels by expressing one or more genes that encode a enzyme that causes the production of NADPH. The system can be combined with other enzymes that require NADPH, thus improving the overall production of the desired protein.
    Type: Application
    Filed: November 12, 2004
    Publication date: September 8, 2005
    Applicant: Rice University
    Inventors: Ka-Yiu San, George Bennett, Ailen Sanchez
  • Aerobic succinate production in bacteria
    Publication number: 20050170482
    Abstract: Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.
    Type: Application
    Filed: November 12, 2004
    Publication date: August 4, 2005
    Applicant: Rice University
    Inventors: Ka-Yiu San, George Bennett, Henry Lin
  • High molar succinate yield bacteria by increasing the intracellular NADH availability
    Publication number: 20050042736
    Abstract: The invention relates to increasing the yield of succinate in bacteria by increasing the intracellular availability of cofactors such as NADH.
    Type: Application
    Filed: August 20, 2004
    Publication date: February 24, 2005
    Inventors: Ka-Yiu San, George Bennett, Ailen Sanchez
  • Increased bacterial CoA and acetyl-CoA pools
    Publication number: 20040199941
    Abstract: Methods of increasing the cellular pool of A-CoA and thus driving the metabolic pathways in the direction of A-CoA containing metabolites by overexpressing rate limiting enzymes in A-CoA synthesis. Methods of increasing intracellular levels of CoA and A-CoA through genetic engineering of bacterial strains in conjunction with supplementation with precursor molecules.
    Type: Application
    Filed: March 24, 2004
    Publication date: October 7, 2004
    Applicant: Rice University
    Inventors: Ka-Yiu San, George Nelson Bennett, Ravishankar V. Vadali
  • Recycling system for manipulation of intracellular NADH availability
    Publication number: 20030175903
    Abstract: The present invention describes a novel recombinant NADH recycling system that is used as a process for producing reduced compounds. In a specific embodiment, the reduced compounds include ethanol, succinate, lactate, a vitamin, a pharmaceutical and a biodegraded organic molecule. The NADH recycling system effects metabolic flux of reductive pathways in aerobic and anaerobic environments.
    Type: Application
    Filed: November 1, 2002
    Publication date: September 18, 2003
    Inventors: Ka-Yiu San, Susana J. Berrios-Rivera, George N. Bennett