Patents by Inventor Kab-Sig Kim
Kab-Sig Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190091165Abstract: The present invention relates to a method for preparing nanoparticle of active ingredient using lipid as lubricant in milling process, and more specifically, it relates to a method for preparing active ingredient into nanoparticle, which can be properly used in drugs, cosmetics, functional foods, etc., by pulverizing a mixture comprising the active ingredient and a lipid as a lubricant, and a biocompatible polymer having a glass transition temperature of 80° C. or higher by roll mill, and then removing the lipid used as a lubricant therefrom by using supercritical fluid.Type: ApplicationFiled: March 26, 2018Publication date: March 28, 2019Inventors: Kab Sig KIM, Eun Yong LEE, Si On KANG, Jae Woo CHOI, Jeong Kyu KIM, Joo Won PARK, Won Suk LEE, Yong Suk JIN
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Patent number: 9439871Abstract: The present invention relates to a method for manufacturing nano-scale particles of an active material. More particularly, the present invention relates to a method which uniformly mixes a surfactant having an HLB value of 8 or more and a melting point or glass transition temperature of 80° C. or lower and an active material, and mills the mixture using a roller mill, to thereby prepare nanoparticle powder from the active material.Type: GrantFiled: September 21, 2012Date of Patent: September 13, 2016Assignee: BIO-SYNECTICS, INC.Inventors: Kab Sig Kim, Joo Won Park
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Patent number: 9393201Abstract: The present invention relates to a nanoparticle of oxaliplatin, which is a water-soluble active substance, a pharmaceutical composition containing the same, and a method for preparing an orally administrable oxaliplatin nanoparticle by 5 emulsifying a lipid mixture solution wherein a solid lipid and a surfactant are mixed in an aqueous mixture solution wherein oxaliplatin and a specific cosolvent are mixed and then removing the solid lipid and the cosolvent using a supercritical fluid gas.Type: GrantFiled: September 20, 2010Date of Patent: July 19, 2016Assignees: JW Pharmaceutical Corporation, Bio-Synectics, Inc.Inventors: Sung Jae Lee, Young Hoon Kim, Sang Heon Lee, Kab Sig Kim
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Publication number: 20150031707Abstract: The present invention relates to a method for manufacturing nano-scale particles of an active material. More particularly, the present invention relates to a method which uniformly mixes a surfactant having an HLB value of 8 or more and a melting point or glass transition temperature of 80° C. or lower and an active material, and mills the mixture using a roller mill, to thereby prepare nanoparticle powder from the active material.Type: ApplicationFiled: September 21, 2012Publication date: January 29, 2015Applicant: BIO-SYNECTICS INC.Inventors: Kab Sig Kim, Joo Won Park
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Patent number: 8828445Abstract: The present invention relates to a method for preparing nano-particles, and more particularly, to a method for preparing nano-particles containing active materials in a simple and highly efficient manner through a grinding process.Type: GrantFiled: March 22, 2011Date of Patent: September 9, 2014Assignee: Bio-Synectics Inc.Inventors: Kab Sig Kim, Joo Won Park
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Publication number: 20130005643Abstract: The present invention relates to a method for preparing nano-particles, and more particularly, to a method for preparing nano-particles containing active materials in a simple and highly efficient manner through a grinding process.Type: ApplicationFiled: March 22, 2011Publication date: January 3, 2013Applicant: Bio-Synetics Inc.Inventors: Kab Sig Kim, Joo Won Park
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Publication number: 20120231093Abstract: The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.Type: ApplicationFiled: May 24, 2012Publication date: September 13, 2012Inventor: Kab-Sig KIM
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Publication number: 20120177728Abstract: The present invention relates to a nanoparticle of oxaliplatin, which is a water-soluble active substance, a pharmaceutical composition containing the same, and a method for preparing an orally administrable oxaliplatin nanoparticle by emulsifying a lipid mixture solution wherein a solid lipid and a surfactant are mixed in an aqueous mixture solution wherein oxaliplatin and a specific cosolvent are mixed and then removing the solid lipid and the cosolvent using a supercritical fluid gas. By providing oxaliplatin, which is currently available only in injection form for parenteral administration, in the form of a nanoparticle, the present invention allows for the development of orally administrable oxaliplatin which is stable against gastric acid and has improved bioavailability, thereby improving patient compliance through avoiding the inconvenience of injection and greatly reducing medical cost.Type: ApplicationFiled: September 20, 2010Publication date: July 12, 2012Applicants: Bio-Synectics, Inc., JW Pharmaceutical CorporationInventors: Sung Jae Lee, Young Hoon Kim, Sang Heon Lee, Kab Sig Kim
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Patent number: 8211470Abstract: The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.Type: GrantFiled: November 11, 2004Date of Patent: July 3, 2012Assignee: Bio-Synectics Inc.Inventor: Kab-Sig Kim
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Patent number: 7994157Abstract: Disclosed are a method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed beverage. The dispersion of plant sterols starts with the admixing of plant sterol to at least one emulsifier selected from the group consisting of sucrose fatty acid ester, sorbitan fatty acid ester and polyglycerine fatty acid ester, followed by melting the admixture by heating at 60 to 200° C. Afterwards, the molten substance is mixed with an aqueous beverage alone or an emulsifier-containing aqueous beverage in state of its own molten type or power type. This resulting mixture is stirred at a high speed to give a dispersion of plant sterols in an aqueous beverage. The beverage is superior in bioavailability, having good mouth feel, transparent aspect and no influence on the characteristic taste, flavor and color of the beverages.Type: GrantFiled: September 28, 2001Date of Patent: August 9, 2011Assignee: KIP Biotech LLCInventors: Won-Tae Yoon, Kab-Sig Kim, Bo-Chun Kim, Jung-Hee Han, Hyung-Pyo Hong
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Patent number: 7615366Abstract: The present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 and a method for controlling plant pathogens using the same. More particularly, the present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 (accession number: KCTC 10564BP) bacterium which has an excellent control effect against crop powdery mildew and a broad spectrum of antifungal activity against plant pathogenic fungi and inhibits tobacco mosaic virus infection, as well as an eco-friendly bacterial culture broth for controlling powdery mildew, which contains the same. Also, the present invention relates to antifungal substance KTGB0202AFO1 obtained by extraction and purification from the Bacillus amyloliquefaciens KTGB0202 bacteria. The inventive Bacillus amyloliquefaciens KTGB0202 bacteria have a broad spectrum of antifungal activity, and are excellent in activity continuance and used for controlling various plant pathogens, including powdery mildew.Type: GrantFiled: December 7, 2004Date of Patent: November 10, 2009Assignee: KT & G Co., Ltd.Inventors: Kab-Sig Kim, Woon-Hyung Yeo
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Publication number: 20090202646Abstract: Disclosed herein is a method for preparing nanoscale particles of active material with using a gas of a supercritical fluid, by dissolving an active material into a solvent which is in solid phase at room temperature, to produce nanoscale particles of the active materials which can be advantageously used in medicine, cosmetics, functional foods or the like.Type: ApplicationFiled: May 3, 2007Publication date: August 13, 2009Inventors: Kab Sig Kim, Young Tai Cho
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Publication number: 20080102062Abstract: The present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 and a method for controlling plant pathogens using the same. More particularly, the present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 (accession number: KCTC 10564BP) bacterium which has an excellent control effect against crop powdery mildew and a broad spectrum of antifungal activity against plant pathogenic fungi and inhibits tobacco mosaic virus infection, as well as an eco-friendly bacterial culture broth for controlling powdery mildew, which contains the same. Also, the present invention relates to antifungal substance KTGB0202 AFO1 obtained by extraction and purification from the Bacillus amyloliquefaciens KTGB0202 bacteria. The inventive Bacillus amyloliquefaciens KTGB0202 bacteria have a broad spectrum of antifungal activity, and are excellent in activity continuance and used for controlling various plant pathogens, including powdery mildew.Type: ApplicationFiled: December 7, 2004Publication date: May 1, 2008Inventors: Kab-Sig Kim, Woon-Hyung Yeo
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Publication number: 20070071826Abstract: The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.Type: ApplicationFiled: November 11, 2004Publication date: March 29, 2007Applicant: BIO-SYNECTICS INC.Inventor: Kab-Sig Kim
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Publication number: 20050170064Abstract: Disclosed are the plant sterol-containing food, and methods for preparing the same. The particle size of the plant sterol contained in the food is nanometer-scale, and the plant sterol-containing food of the present invention inhibits the absorption of cholesterol.Type: ApplicationFiled: March 20, 2002Publication date: August 4, 2005Applicant: Eugene Science Inc.Inventors: Won-Tae Yoon, Kab-Sig Kim, Bo-Chun Kim, Jung-Hee Han
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Publication number: 20050118203Abstract: Disclosed are a mixing powder of plant sterol and emulsifier, and method for preparing the same. More particularly, the present invention provides a mixing powder of plant sterol and emulsifier for application to almost all food, irrespective of food base, to obtain an improvement in the dispersion stability of the plant sterol micelles inhibiting the absorption of cholesterol.Type: ApplicationFiled: March 20, 2002Publication date: June 2, 2005Inventors: Won-Tae Yoon, Kab-Sig Kim, Tae-Jin Kim, Hyung-Pyo Hong
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Publication number: 20040029844Abstract: Disclosed are a method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed beverage. The dispersion of plant sterols starts with the admixing of plant sterol to at least one emulsifier selected from the group consisting of sucrose fatty acid ester, sorbitan fatty acid ester and polyglycerine fatty acid ester, followed by melting the admixture by heating at 60 to 200° C. Afterwards, the molten substance is mixed with an aqueous beverage alone or an emulsifier-containing aqueous beverage in state of its own molten type or power type. This resulting mixture is stirred at a high speed to give a dispersion of plant sterols in an aqueous beverage. The beverage is superior in bioavailability, having good mouth feel, transparent aspect and no influence on the characteristic taste, flavor and color of the beverages.Type: ApplicationFiled: July 30, 2003Publication date: February 12, 2004Inventors: Won-Tae Yoon, Kab-Sig Kim, Bo-Chug Kim, Jung-Hee Han
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Publication number: 20020064548Abstract: Disclosed are a method for dispersing plant sterol in aqueous substrates and a plant sterol-dispersed beverage. The dispersion of plant sterols starts with the admixing of plant sterol to an emulsifier, followed by melting the admixture by heating at 60 to 200° C. Afterwards, the molten substance is mixed with an aqueous beverage alone or an emulsifier-containing aqueous beverage. This resulting mixture is stirred at a high speed to give a dispersion of plant sterols in an aqueous beverage. Optionally, the dispersion may be homogenized. In the beverage thus obtained, there are contained nano-sized micelles which are superior in bioavailability, having no influence on the characteristic taste and flavor of the beverages. Also, the improvement in the dispersion stability of the plant sterol micelles has the effect of prolonging the life span of the beverage, guaranteeing the stability of the products for a long period of time.Type: ApplicationFiled: December 20, 2000Publication date: May 30, 2002Inventors: Won-Tae Yoon, Kab-Sig Kim, Bo-Chun Kim, Jung-Hee Han, Hyung-Pyo Hong