Patents by Inventor Kab-Sig Kim

Kab-Sig Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190091165
    Abstract: The present invention relates to a method for preparing nanoparticle of active ingredient using lipid as lubricant in milling process, and more specifically, it relates to a method for preparing active ingredient into nanoparticle, which can be properly used in drugs, cosmetics, functional foods, etc., by pulverizing a mixture comprising the active ingredient and a lipid as a lubricant, and a biocompatible polymer having a glass transition temperature of 80° C. or higher by roll mill, and then removing the lipid used as a lubricant therefrom by using supercritical fluid.
    Type: Application
    Filed: March 26, 2018
    Publication date: March 28, 2019
    Inventors: Kab Sig KIM, Eun Yong LEE, Si On KANG, Jae Woo CHOI, Jeong Kyu KIM, Joo Won PARK, Won Suk LEE, Yong Suk JIN
  • Patent number: 9439871
    Abstract: The present invention relates to a method for manufacturing nano-scale particles of an active material. More particularly, the present invention relates to a method which uniformly mixes a surfactant having an HLB value of 8 or more and a melting point or glass transition temperature of 80° C. or lower and an active material, and mills the mixture using a roller mill, to thereby prepare nanoparticle powder from the active material.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: September 13, 2016
    Assignee: BIO-SYNECTICS, INC.
    Inventors: Kab Sig Kim, Joo Won Park
  • Patent number: 9393201
    Abstract: The present invention relates to a nanoparticle of oxaliplatin, which is a water-soluble active substance, a pharmaceutical composition containing the same, and a method for preparing an orally administrable oxaliplatin nanoparticle by 5 emulsifying a lipid mixture solution wherein a solid lipid and a surfactant are mixed in an aqueous mixture solution wherein oxaliplatin and a specific cosolvent are mixed and then removing the solid lipid and the cosolvent using a supercritical fluid gas.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: July 19, 2016
    Assignees: JW Pharmaceutical Corporation, Bio-Synectics, Inc.
    Inventors: Sung Jae Lee, Young Hoon Kim, Sang Heon Lee, Kab Sig Kim
  • Publication number: 20150031707
    Abstract: The present invention relates to a method for manufacturing nano-scale particles of an active material. More particularly, the present invention relates to a method which uniformly mixes a surfactant having an HLB value of 8 or more and a melting point or glass transition temperature of 80° C. or lower and an active material, and mills the mixture using a roller mill, to thereby prepare nanoparticle powder from the active material.
    Type: Application
    Filed: September 21, 2012
    Publication date: January 29, 2015
    Applicant: BIO-SYNECTICS INC.
    Inventors: Kab Sig Kim, Joo Won Park
  • Patent number: 8828445
    Abstract: The present invention relates to a method for preparing nano-particles, and more particularly, to a method for preparing nano-particles containing active materials in a simple and highly efficient manner through a grinding process.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: September 9, 2014
    Assignee: Bio-Synectics Inc.
    Inventors: Kab Sig Kim, Joo Won Park
  • Publication number: 20130005643
    Abstract: The present invention relates to a method for preparing nano-particles, and more particularly, to a method for preparing nano-particles containing active materials in a simple and highly efficient manner through a grinding process.
    Type: Application
    Filed: March 22, 2011
    Publication date: January 3, 2013
    Applicant: Bio-Synetics Inc.
    Inventors: Kab Sig Kim, Joo Won Park
  • Publication number: 20120231093
    Abstract: The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.
    Type: Application
    Filed: May 24, 2012
    Publication date: September 13, 2012
    Inventor: Kab-Sig KIM
  • Publication number: 20120177728
    Abstract: The present invention relates to a nanoparticle of oxaliplatin, which is a water-soluble active substance, a pharmaceutical composition containing the same, and a method for preparing an orally administrable oxaliplatin nanoparticle by emulsifying a lipid mixture solution wherein a solid lipid and a surfactant are mixed in an aqueous mixture solution wherein oxaliplatin and a specific cosolvent are mixed and then removing the solid lipid and the cosolvent using a supercritical fluid gas. By providing oxaliplatin, which is currently available only in injection form for parenteral administration, in the form of a nanoparticle, the present invention allows for the development of orally administrable oxaliplatin which is stable against gastric acid and has improved bioavailability, thereby improving patient compliance through avoiding the inconvenience of injection and greatly reducing medical cost.
    Type: Application
    Filed: September 20, 2010
    Publication date: July 12, 2012
    Applicants: Bio-Synectics, Inc., JW Pharmaceutical Corporation
    Inventors: Sung Jae Lee, Young Hoon Kim, Sang Heon Lee, Kab Sig Kim
  • Patent number: 8211470
    Abstract: The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.
    Type: Grant
    Filed: November 11, 2004
    Date of Patent: July 3, 2012
    Assignee: Bio-Synectics Inc.
    Inventor: Kab-Sig Kim
  • Patent number: 7994157
    Abstract: Disclosed are a method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed beverage. The dispersion of plant sterols starts with the admixing of plant sterol to at least one emulsifier selected from the group consisting of sucrose fatty acid ester, sorbitan fatty acid ester and polyglycerine fatty acid ester, followed by melting the admixture by heating at 60 to 200° C. Afterwards, the molten substance is mixed with an aqueous beverage alone or an emulsifier-containing aqueous beverage in state of its own molten type or power type. This resulting mixture is stirred at a high speed to give a dispersion of plant sterols in an aqueous beverage. The beverage is superior in bioavailability, having good mouth feel, transparent aspect and no influence on the characteristic taste, flavor and color of the beverages.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: August 9, 2011
    Assignee: KIP Biotech LLC
    Inventors: Won-Tae Yoon, Kab-Sig Kim, Bo-Chun Kim, Jung-Hee Han, Hyung-Pyo Hong
  • Patent number: 7615366
    Abstract: The present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 and a method for controlling plant pathogens using the same. More particularly, the present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 (accession number: KCTC 10564BP) bacterium which has an excellent control effect against crop powdery mildew and a broad spectrum of antifungal activity against plant pathogenic fungi and inhibits tobacco mosaic virus infection, as well as an eco-friendly bacterial culture broth for controlling powdery mildew, which contains the same. Also, the present invention relates to antifungal substance KTGB0202AFO1 obtained by extraction and purification from the Bacillus amyloliquefaciens KTGB0202 bacteria. The inventive Bacillus amyloliquefaciens KTGB0202 bacteria have a broad spectrum of antifungal activity, and are excellent in activity continuance and used for controlling various plant pathogens, including powdery mildew.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: November 10, 2009
    Assignee: KT & G Co., Ltd.
    Inventors: Kab-Sig Kim, Woon-Hyung Yeo
  • Publication number: 20090202646
    Abstract: Disclosed herein is a method for preparing nanoscale particles of active material with using a gas of a supercritical fluid, by dissolving an active material into a solvent which is in solid phase at room temperature, to produce nanoscale particles of the active materials which can be advantageously used in medicine, cosmetics, functional foods or the like.
    Type: Application
    Filed: May 3, 2007
    Publication date: August 13, 2009
    Inventors: Kab Sig Kim, Young Tai Cho
  • Publication number: 20080102062
    Abstract: The present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 and a method for controlling plant pathogens using the same. More particularly, the present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 (accession number: KCTC 10564BP) bacterium which has an excellent control effect against crop powdery mildew and a broad spectrum of antifungal activity against plant pathogenic fungi and inhibits tobacco mosaic virus infection, as well as an eco-friendly bacterial culture broth for controlling powdery mildew, which contains the same. Also, the present invention relates to antifungal substance KTGB0202 AFO1 obtained by extraction and purification from the Bacillus amyloliquefaciens KTGB0202 bacteria. The inventive Bacillus amyloliquefaciens KTGB0202 bacteria have a broad spectrum of antifungal activity, and are excellent in activity continuance and used for controlling various plant pathogens, including powdery mildew.
    Type: Application
    Filed: December 7, 2004
    Publication date: May 1, 2008
    Inventors: Kab-Sig Kim, Woon-Hyung Yeo
  • Publication number: 20070071826
    Abstract: The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.
    Type: Application
    Filed: November 11, 2004
    Publication date: March 29, 2007
    Applicant: BIO-SYNECTICS INC.
    Inventor: Kab-Sig Kim
  • Publication number: 20050170064
    Abstract: Disclosed are the plant sterol-containing food, and methods for preparing the same. The particle size of the plant sterol contained in the food is nanometer-scale, and the plant sterol-containing food of the present invention inhibits the absorption of cholesterol.
    Type: Application
    Filed: March 20, 2002
    Publication date: August 4, 2005
    Applicant: Eugene Science Inc.
    Inventors: Won-Tae Yoon, Kab-Sig Kim, Bo-Chun Kim, Jung-Hee Han
  • Publication number: 20050118203
    Abstract: Disclosed are a mixing powder of plant sterol and emulsifier, and method for preparing the same. More particularly, the present invention provides a mixing powder of plant sterol and emulsifier for application to almost all food, irrespective of food base, to obtain an improvement in the dispersion stability of the plant sterol micelles inhibiting the absorption of cholesterol.
    Type: Application
    Filed: March 20, 2002
    Publication date: June 2, 2005
    Inventors: Won-Tae Yoon, Kab-Sig Kim, Tae-Jin Kim, Hyung-Pyo Hong
  • Publication number: 20040029844
    Abstract: Disclosed are a method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed beverage. The dispersion of plant sterols starts with the admixing of plant sterol to at least one emulsifier selected from the group consisting of sucrose fatty acid ester, sorbitan fatty acid ester and polyglycerine fatty acid ester, followed by melting the admixture by heating at 60 to 200° C. Afterwards, the molten substance is mixed with an aqueous beverage alone or an emulsifier-containing aqueous beverage in state of its own molten type or power type. This resulting mixture is stirred at a high speed to give a dispersion of plant sterols in an aqueous beverage. The beverage is superior in bioavailability, having good mouth feel, transparent aspect and no influence on the characteristic taste, flavor and color of the beverages.
    Type: Application
    Filed: July 30, 2003
    Publication date: February 12, 2004
    Inventors: Won-Tae Yoon, Kab-Sig Kim, Bo-Chug Kim, Jung-Hee Han
  • Publication number: 20020064548
    Abstract: Disclosed are a method for dispersing plant sterol in aqueous substrates and a plant sterol-dispersed beverage. The dispersion of plant sterols starts with the admixing of plant sterol to an emulsifier, followed by melting the admixture by heating at 60 to 200° C. Afterwards, the molten substance is mixed with an aqueous beverage alone or an emulsifier-containing aqueous beverage. This resulting mixture is stirred at a high speed to give a dispersion of plant sterols in an aqueous beverage. Optionally, the dispersion may be homogenized. In the beverage thus obtained, there are contained nano-sized micelles which are superior in bioavailability, having no influence on the characteristic taste and flavor of the beverages. Also, the improvement in the dispersion stability of the plant sterol micelles has the effect of prolonging the life span of the beverage, guaranteeing the stability of the products for a long period of time.
    Type: Application
    Filed: December 20, 2000
    Publication date: May 30, 2002
    Inventors: Won-Tae Yoon, Kab-Sig Kim, Bo-Chun Kim, Jung-Hee Han, Hyung-Pyo Hong