Patents by Inventor Kacey Gribbin Marra

Kacey Gribbin Marra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for reconstruction of nerve defects
    Patent number: 11623022
    Abstract: Composite nerve guides for nerve regeneration are provided, wherein the composite guide comprise a nerve graft and a nerve conduit continuing an active agent that promote axon regeneration. The devices can provide structural supports to guide nerve regeneration and locally deliver an active agent (e.g., glial cell-line derived neurotrophic factor (GDNF) and/or glial growth factor 2 (GGF2) to injured nervous system tissue upon implantation in a subject. Methods of treatment using such devices are also provided.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: April 11, 2023
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Kacey Gribbin Marra, Jacqueline Wittmer
  • AUTOMATION MECHANISM FOR PRE/CLINICAL PRODUCTION OF RESORBABLE NERVE GUIDES
    Publication number: 20210402654
    Abstract: The presently disclosed subject matter relates to systems for making an implantable construct comprising a reservoir coupled to the at least one frame; a mandrel base coupled to the at least one frame; a mandrel coupled to the mandrel base; a first mechanism configured to be coupled to the at least one frame and configured to move the at least one frame along a first axis; a second mechanism configured to be coupled to the at least one frame and configured to rotate the least one mandrel base along a second axis between a first orientation and a second orientation; and a container configured to be coupled to the at least one frame and configured to receive the mandrel in the second orientation. The disclosed mechanisms can manually, semi-automatically, or automatically control the movements of the at least one frame, reservoir, mandrel, mandrel base, and container to produce the construct with a lumen. The presently disclosed subject matter also relates to methods for making the construct.
    Type: Application
    Filed: September 14, 2021
    Publication date: December 30, 2021
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Alexander James Repko, Kacey Gribbin Marra, Benjamin Schilling
  • Implantable medical devices having double walled microspheres
    Patent number: 11147904
    Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: October 19, 2021
    Assignee: University Of Pittsburgh—Of The Commonwealth System Of Higher Education
    Inventors: Lauren Elizabeth Kokai, Kacey Gribbin Marra
  • SYSTEMS AND METHODS FOR RECONSTRUCTION OF NERVE DEFECTS
    Publication number: 20200368390
    Abstract: Composite nerve guides for nerve regeneration are provided, wherein the composite guide comprise a nerve graft and a nerve conduit continuing an active agent that promote axon regeneration. The devices can provide structural supports to guide nerve regeneration and locally deliver an active agent (e.g., glial cell-line derived neurotrophic factor (GDNF) and/or glial growth factor 2 (GGF2) to injured nervous system tissue upon implantation in a subject. Methods of treatment using such devices are also provided.
    Type: Application
    Filed: November 13, 2018
    Publication date: November 26, 2020
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Kacey Gribbin Marra, Jacqueline Bliley
  • IMPLANTABLE MEDICAL DEVICES HAVING DOUBLE WALLED MICROSPHERES
    Publication number: 20170354762
    Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
    Type: Application
    Filed: August 4, 2017
    Publication date: December 14, 2017
    Applicant: University Of Pittsburgh - Of The Commonwealth System Of Higher Education
    Inventors: Lauren Elizabeth Kokai, Kacey Gribbin Marra
  • Implantable medical devices having double walled microspheres
    Patent number: 9750851
    Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: September 5, 2017
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Lauren Elizabeth Kokai, Kacey Gribbin Marra
  • IMPLANTABLE MEDICAL DEVICES HAVING DOUBLE WALLED MICROSPHERES
    Publication number: 20170043059
    Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
    Type: Application
    Filed: October 26, 2016
    Publication date: February 16, 2017
    Applicant: University Of Pittsburgh - Of The Commonwealth System Of Higher Education
    Inventors: Lauren Elizabeth Kokai, Kacey Gribbin Marra
  • Implantable medical devices having double walled microspheres
    Patent number: 9498221
    Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: November 22, 2016
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Lauren E. Kokai, Kacey Gribbin Marra