Abstract: A treatment system can include a channel generation system configured to expose an infected region of a target tissue with a laser beam traveling along an optical axis and focused at a focal volume located in or adjacent to the target tissue. The laser beam can have a wavelength ranging from about 100 nm to about 400 nm. The laser beam can be configured to generate at least a first channel in the infected region. The treatment system can also include a detection system configured to detect a first radiation generated by one or more of (i) the target tissue, (ii) a fungi coupled to the infected region in the target tissue, and (iii) an adjacent tissue located proximal to the target tissue as a result of interaction with the laser beam. The treatment system can also include a delivery system configured to deposit an active treatment agent in the at least first channel.

Abstract: Systems and methods for a laser-assisted topical treatment of nail fungal infections are provided. The laser-assisted topical treatment includes a laser that is configured to output a beam that penetrates the infected nail and creates a channel therethrough. The laser-assisted topical treatment further includes a treatment agent comprising a vehicle and a drug. The treatment agent is applied to an exterior surface of the infected nail so that the treatment agent may flow into the channel.

Abstract: Systems and methods for a laser-assisted topical treatment of nail fungal infections are provided. The laser-assisted topical treatment includes a laser that is configured to output a beam that penetrates the infected nail and creates a channel therethrough. The laser-assisted topical treatment further includes a treatment agent comprising a vehicle and a drug. The treatment agent is applied to an exterior surface of the infected nail so that the treatment agent may flow into the channel.

Abstract: A treatment system can include a channel generation system configured to expose an infected region of a target tissue with a laser beam traveling along an optical axis and focused at a focal volume located in or adjacent to the target tissue. The laser beam can have a wavelength ranging from about 100 nm to about 400 nm. The laser beam can be configured to generate at least a first channel in the infected region. The treatment system can also include a detection system configured to detect a first radiation generated by one or more of (i) the target tissue, (ii) a fungi coupled to the infected region in the target tissue, and (iii) an adjacent tissue located proximal to the target tissue as a result of interaction with the laser beam. The treatment system can also include a delivery system configured to deposit an active treatment agent in the at least first channel.

Abstract: Systems and methods for a laser-assisted topical treatment of nail fungal infections are provided. The laser-assisted topical treatment includes a laser that is configured to output a beam that penetrates the infected nail and creates a channel therethrough. The laser-assisted topical treatment further includes a treatment agent comprising a vehicle and a drug. The treatment agent is applied to an exterior surface of the infected nail so that the treatment agent may flow into the channel.