Abstract: Multi-modal, portable, handheld devices for tissue assessment (e.g., wound assessment) are provided, as are methods of fabricating and methods of using the same. The devices can be used for virtual medicine (VM)-based wound management, such as VM-based diabetic foot triage (DFT) and management. The device can be used to take physiological measurements of temperature and/or tissue oxygenation of a wound to assess the wound, for example in a remote setting environment. The device can also be used to provide therapy for tissue repair and/or wound healing, apart from the multi-modal imaging of the tissue surface of the patient. For example, light therapy, such as low-level light therapy (LLLT) can be provided via one or more light emitting diodes (LEDs) and/or laser diodes.

Abstract: A cellphone-based oxygenation tool can include a circuitry housing unit, a light emitting diode (LED) box disposed on the circuitry housing unit, a plurality of LEDs disposed in the LED box, a diffuser sheet or lens disposed on the LED box, a lens holder disposed on the circuitry housing unit and configured to be movable with respect to the circuitry housing unit, a near-infrared (NIR) filter disposed on the lens holder, and a cellphone disposed on the circuitry housing unit and having an NIR sensitive camera. Each of the plurality of LEDs can have different wavelengths, and application software of the cellphone can be configured to acquire data from the NIR sensitive camera and process the data before storing the data.

Abstract: A cellphone-based oxygenation tool can include a circuitry housing unit, a light emitting diode (LED) box disposed on the circuitry housing unit, a plurality of LEDs disposed in the LED box, a diffuser sheet or lens disposed on the LED box, a lens holder disposed on the circuitry housing unit and configured to be movable with respect to the circuitry housing unit, a near-infrared (NIR) filter disposed on the lens holder, and a cellphone disposed on the circuitry housing unit and having an NIR sensitive camera. Each of the plurality of LEDs can have different wavelengths, and application software of the cellphone can be configured to acquire data from the NIR sensitive camera and process the data before storing the data.