Patents by Inventor Kadi Liis Saar
Kadi Liis Saar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240006018Abstract: A computer implemented method of predicting liquid-liquid phase separation LLPS) behaviour of a biomolecule, the method comprising: inputting information identifying the biomolecule and its environmental composition and/or chemical modification of the biomolecule to an algorithm configured to predict, whether the biomolecule will exhibit LLPS under specified environmental conditions and/or chemical modification of the biomolecule, wherein: the algorithm is an algorithm generated by machine learning trained on data featurised according to features relating to biomolecules in the training data and features relating to the environmental conditions and/or chemical modification of the biomolecules in the training data, and the algorithm outputs a prediction of whether the biomolecule will exhibit LLPS under the specified environmental conditions and/or chemical modification of the biomolecule.Type: ApplicationFiled: October 26, 2021Publication date: January 4, 2024Inventors: Tuomas P. J. KNOWLES, Kadi Liis SAAR, Alekszej MORGUNOV
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Publication number: 20230211344Abstract: The present invention is directed to methods and devices capable of target analyte separation and analysis, in particular highly sensitive separation and detection and free-solution analyte detection assays.Type: ApplicationFiled: March 5, 2021Publication date: July 6, 2023Applicant: Cambridge Enterprise LimitedInventors: Tuomas Pertti Jonathan Knowles, Kadi Liis Saar, Georg Krainer, William Emrys Arter
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Publication number: 20220365075Abstract: The present invention relates to the identification of proteins involving measurement and characterisation of multidimensional aspects of said proteins.Type: ApplicationFiled: September 25, 2020Publication date: November 17, 2022Applicant: Cambridge Enterprise LimitedInventors: Tuomas Pertti Jonathan Knowles, Kadi Liis Saar, Alekszej Morgunov
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Publication number: 20220026405Abstract: A device and a method is provided for profiling particles such as proteins. The device comprises: a liquid chromatography column (16) in a mixture separation module (10); a fractionation device (22, 24) and a plurality of microfluidic analysis modules (26, 28) in a microfluidic network (14). The microfluidic analysis modules are configured to provide multi-dimensional analysis of the particles. Furthermore, a fluidic flow adaptor (20) allows for controlled flow between separator (16) and the microfluidic network to provide a continuous fluid flow.Type: ApplicationFiled: September 19, 2019Publication date: January 27, 2022Applicants: Fluidic Analytics Limited, Cambridge Enterprise LimitedInventors: Tadas Kartanas, Tuomas Pertti Jonathan Knowles, Quentin Alexis Eric Peter, Kadi Liis Saar, Tom Scheidt, Thomas Mueller, Sean Devenish
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Publication number: 20220016627Abstract: A flow apparatus for detecting a component on a surface is provided. The flow apparatus, comprising an inlet for receiving a solution of the components to be detected; a detection chamber in fluid connection with and downstream from the inlet, and in fluid connection with a downstream outlet, wherein the internal surface of the detection chamber comprises a plurality of detection zones and the detection zones are configured to adhere to the component to be detected such that the component is immobilised in the detection zones; a detector for detecting components immobilised on each of the detection zones; and a director for directing the flow of the solution of the components to each of the detection zones in sequence, wherein the director is provided by flow rates.Type: ApplicationFiled: December 20, 2019Publication date: January 20, 2022Applicants: Fluidic Analytics Limilted, Cambridge Enterprise LimitedInventors: Tuomas Pertti Jonathan Knowles, Kadi Liis Saar, Quentin Alexia Eric Peter, Pavan Kumar Challa, Thomas Mueller
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Publication number: 20220012456Abstract: A method of optically characterizing individual molecules/molecular complexes, or other particles, in solution. The method comprises flowing a solution comprising the molecules/molecular complexes into an imaging region of a microfluidic channel, wherein the imaging region of the microfluidic channel has a first lateral dimension of greater than 1 ?m in an x-direction wherein the x-direction is perpendicular to a direction of the flow; capturing a succession of images of the individual molecules/molecular complexes in the imaging region; tracking movement of the individual molecules/molecular complexes in at least the x-direction in the imaging region using the succession of images; and characterizing the individual molecules/molecular complexes from the tracked movement. In some implementations the characterizing comprises determining a diffusion coefficient of the molecules/molecular complexes from the tracked movement.Type: ApplicationFiled: November 22, 2019Publication date: January 13, 2022Applicant: Cambridge Enterprise LimitedInventors: Tuomas Pertti Jonathan Knowles, Pavan Kumar Challa, Kadi Liis Saar, Quentin Alexis Peter, Clemens Kaminski, Oliver Vanderpoorten
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Publication number: 20220011560Abstract: A method of increasing the interference contrast in interferometric scattering optical microscopy. The method comprises providing a particle detection region comprising a chamber or channel having a boundary defined by one or more interfaces, illuminating a particle in the particle detection region with coherent light using an objective lens such that the light is reflected from the interface and scattered by the particle, capturing the reflected light and the scattered light using the objective lens, and providing the captured reflected and scattered light to an imaging device to image interference between the reflected light and the scattered light. The particle is illuminated by coherent light at an oblique angle to the interface.Type: ApplicationFiled: November 22, 2019Publication date: January 13, 2022Applicant: Cambridge Enterprise LimitedInventors: Tuomas Pertti Jonathan Knowles, Pavan Kumar Challa, Kadi Liis Saar, Quentin Alexis Peter, Zenon Toprakcioglu
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Publication number: 20200298236Abstract: A fluidic device is provided. The fluidic device comprises a separation channel having at its upstream end a junction, a first channel for supplying a first fluid flow, a second channel for supplying a second fluid flow. The first and second channels meet at the junction are adapted to provide the first fluid flow in the separation channel sheathed by the second fluid flow, such that the first fluid flow does not contact the separation channel walls. The separation channel, the first and second channels are provided as a unitary piece, or where the separation channel and the first and second channels are provided as a non-unitary piece comprising a plurality of parts, the parts are of the same material.Type: ApplicationFiled: December 11, 2018Publication date: September 24, 2020Applicants: Cambridge Enterprise Limited, Fluidic Analytics LimitedInventors: Tuomas Pertti Jonathan Knowles, Kadi Liis Saar, Tadas Kartanas, Thomas Mueller