Patents by Inventor Kady-Ann C. Steen-Burrell

Kady-Ann C. Steen-Burrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THROMBUS IMAGING APTAMERS AND METHODS OF USING SAME
    Publication number: 20230330271
    Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.
    Type: Application
    Filed: December 21, 2022
    Publication date: October 19, 2023
    Inventors: Bruce A. Sullenger, Kady-Ann C. Steen-Burrell, Bethany Powell Gray
  • Thrombus imaging aptamers and methods of using same
    Patent number: 11565002
    Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: January 31, 2023
    Assignee: Duke University
    Inventors: Bruce A. Sullenger, Kady-Ann C. Steen-Burrell, Bethany Powell Gray
  • THROMBUS IMAGING APTAMERS AND METHODS OF USING SAME
    Publication number: 20200353102
    Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.
    Type: Application
    Filed: May 21, 2020
    Publication date: November 12, 2020
    Applicant: Duke University
    Inventors: Bruce A. Sullenger, Kady-Ann C. Steen-Burrell, Bethany Powell Gray
  • Thrombus imaging aptamers and methods of using same
    Patent number: 10660973
    Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: May 26, 2020
    Assignee: Duke University
    Inventors: Bruce A. Sullenger, Kady-Ann C. Steen-Burrell, Bethany Powell Gray
  • THROMBUS IMAGING APTAMERS AND METHODS OF USING SAME
    Publication number: 20180117182
    Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.
    Type: Application
    Filed: April 28, 2016
    Publication date: May 3, 2018
    Applicant: Duke University
    Inventors: Bruce A. Sullenger, Kady-Ann C. Steen-Burrell, Bethany Powell Gray