Abstract: The present disclosure provides a method for preparing an extract of Chrysanthemum morifolium with an effect of treating skin diseases, including: (a) performing an extraction procedure on Chrysanthemum morifolium with an extraction solvent to obtain an extract solution; and (b) adding at least one glycoside hydrolases to the extract solution to make an enzyme reaction occur to produce a precipitate, wherein the precipitate is the extract of Chrysanthemum morifolium with an effect of treating skin diseases.

Abstract: A composition for inhibiting skin cell proliferation and/or anti-inflammation is provided. The composition for inhibiting skin cell proliferation and/or anti-inflammation includes: apigenin and luteolin, wherein a weight ratio of the apigenin to the luteolin is about 1.5-25:1, or a mole ratio of the apigenin to the luteolin is about 1.5-25:1. Moreover, the apigenin and the luteolin have a synergistic effect on inhibiting skin cell proliferation and/or anti-inflammation.

Abstract: The invention provides a recombinant polypeptide X—Y for enhancing cell transduction efficiency of a target agent, wherein X is a cell penetrating peptide DPV3, and Y is an Hsp40-J domain. Also provided is a method for enhancing cell transduction efficiency of a target agent, comprising conjugating/attaching said target agent with a recombinant polypeptide X—Y, wherein X is a cell penetrating peptide DPV3, and Y is an Hsp40-J domain. Further provided is a pharmaceutical composition comprising a therapeutic agent, wherein said therapeutic agent is modified by conjugating/attaching with a recombinant polypeptide X—Y, wherein X is a cell penetrating peptide DPV3, and Y is an Hsp40-J domain.

Abstract: The present disclosure provides a communication method for virtual machines, an electronic device, and a non-transitory computer readable storage medium. The communication method for virtual machines suitable for a virtual machine architecture comprises the steps of: transmitting, through a shared link, an interrupt instruction to a second virtual machine by a first virtual machine; reading, in a shared configuration database, an instruction data corresponding to the interrupt instruction by the second virtual machine; and executing the instruction data and transmitting a result data through a virtual control plane to the first virtual machine by the second virtual machine, to exchange the data between the first virtual machine and the second virtual machine through the virtual control plane.

Abstract: The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

Abstract: The invention is a pet feeding device provides a feeding mechanism on a basis of fixed time and fixed amount of food for a pet. The pet feeding device includes a base and a rotatable tray. The base has a first opening and a second opening communicated with each other, and the second opening connects the base and an exterior environment. The rotatable tray having third openings is assembled to the base and rotates about an axis. The feed pellets received in the pet feeding device fall into the third openings with a rotation of the rotatable tray. In a process of rotation, the first opening covers portion of the third openings correspondingly in a unit time, and the feed pellets in the corresponding third openings drop out of the pet feeding device via the first opening and the second opening.

Abstract: A clock generating device includes a divisor register, a reference clock generator, a first counter, a second counter, and a delay regulator circuit. The divisor register provides a divisor. The reference clock generator outputs a reference clock signal. The first counter counts a first number of cycles of the reference clock signal and generates a first count. The first counter outputs a first clock signal according to the first count and the divisor. The second counter counts a second number of cycles of the first clock signal and generates a second count. The second counter outputs a second clock signal according to the second count and a coefficient. The delay regulator circuit determines whether to control the first counter to delay outputting the first clock signal according to the first clock signal.

Abstract: A water mode detection method includes: operating a normal touch detection operation on each of a plurality of touch detection unit groups during each of a plurality of normal scan periods to obtain a first detection result; operating a dummy touch detection operation on a first touch detection group of the touch detection unit groups to obtain a second detection result during a dummy scan period, and setting a common voltage of a second touch detection group of a plurality of non-scanned touch detection unit groups to a reference ground during the dummy touch detection operation; and generating a water mode detection result according to the first detection result and the second detection result.

Abstract: The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

Abstract: A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15. Also provided is a composition comprising said synthetic peptide with a therapeutic agent fused thereto, and a pharmaceutically acceptable carrier or diluent. Further provided is a method of screening a peptide specifically targeting to a cancer stem cell. The method comprises the steps of establishing an oligopeptide library by using a phage expression system, contacting the library with a culture of bulk tumor cells of a cancer cell line, contacting the phages which do not bind to the bulk tumor cells with a culture of cancer stem cells of said cancer cell line, and screening a peptide specifically targeting to a cancer stem cell from the phages which bind to the cancer stem cells.

Abstract: The present disclosure provides a method for preparing an extract of Chrysanthemum morifolium with an effect of treating skin diseases, including: (a) performing an extraction procedure on Chrysanthemum morifolium with an extraction solvent to obtain an extract solution; and (b) adding at least one glycoside hydrolases to the extract solution to make an enzyme reaction occur to produce a precipitate, wherein the precipitate is the extract of Chrysanthemum morifolium with an effect of treating skin diseases.

Abstract: A water mode detection method includes: operating a normal touch detection operation on each of a plurality of touch detection unit groups during each of a plurality of normal scan periods to obtain a first detection result; operating a dummy touch detection operation on a first touch detection group of the touch detection unit groups to obtain a second detection result during a dummy scan period, and setting a common voltage of a second touch detection group of a plurality of non-scanned touch detection unit groups to a reference ground during the dummy touch detection operation; and generating a water mode detection result according to the first detection result and the second detection result.

Abstract: A pet feeding device receiving a plurality of feed pellets for pet is provided. The pet feeding device includes a base and a rotating tray. The base has a first opening and a second opening communicated with each other, and the second opening connects the base and an exterior environment. The rotating tray having a plurality third openings is assembled to the base and rotates about an axis. The feed pellets received in the pet feeding device fall into the third openings respectively with a rotation of the rotating tray. In a process of rotation, the first opening covers portion of the third openings correspondingly in a unit time, and the feed pellets in the corresponding third openings drop out of the pet feeding device via the first opening and the second opening.

Abstract: A device comprises a coarse timing skew characterization circuit having a buffer chain and a coarse delay cell calibration circuit comprising a first flip-flop, a second flip-flop and a logic gate, wherein the coarse delay cell calibration circuit is configured to measure a delay between an input of the buffer chain and an output of the buffer chain.

Abstract: The invention provides a recombinant polypeptide X—Y for enhancing cell transduction efficiency of a target agent, wherein X is a cell penetrating peptide DPV3, and Y is an Hsp40-J domain. Also provided is a method for enhancing cell transduction efficiency of a target agent, comprising conjugating/attaching said target agent with a recombinant polypeptide X—Y, wherein X is a cell penetrating peptide DPV3, and Y is an Hsp40-J domain. Further provided is a pharmaceutical composition comprising a therapeutic agent, wherein said therapeutic agent is modified by conjugating/attaching with a recombinant polypeptide X—Y, wherein X is a cell penetrating peptide DPV3, and Y is an Hsp40-J domain.

Abstract: A nebulizing device includes a medicament storage module, a nebulizing unit, and a first waterproof gasket. In the medicament storage module, a coupling part is connected with an outer surface of a tubular sidewall and aligned with an outlet of the tubular sidewall, and includes an extension wall and a first recess where the nebulizing unit is disposed. The first waterproof gasket is disposed within the first recess and located on a side of the nebulizing unit farther from the outlet. In the first waterproof gasket, a first opening is disposed adjacent to the nebulizing unit, a second opening is disposed opposite to the first opening and located on a side of the first opening farther from the nebulizing unit, the size of the second opening is greater than that of the first opening, and the annular wall structure is connected to the first opening and the second opening.

Abstract: A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15. Also provided is a composition comprising said synthetic peptide with a therapeutic agent fused thereto, and a pharmaceutically acceptable carrier or diluent. Further provided is a method of screening a peptide specifically targeting to a cancer stem cell. The method comprises the steps of establishing an oligopeptide library by using a phage expression system, contacting the library with a culture of bulk tumor cells of a cancer cell line, contacting the phages which do not bind to the bulk tumor cells with a culture of cancer stem cells of said cancer cell line, and screening a peptide specifically targeting to a cancer stem cell from the phages which bind to the cancer stem cells.

Abstract: In an instant messaging device, a selection is received from a user, where the selection specifying a plurality of contacts to participate in an instant messaging session. At least one attribute type corresponding to the at least one intended recipient is retrieved in response to detecting a trigger event relating to a message intended for at least one recipient among the plurality of contacts. A verification operation is retrieved for each of the retrieved at least one attribute type. At least one retrieved verification operations is executed. The message is sent to the at least one intended recipient in response to successful execution of the at least one of the retrieved verification operations.