Abstract: The invention provides a recombinant polypeptide X—Y for enhancing cell transduction efficiency of a target agent, wherein X is a cell penetrating peptide DPV3, and Y is an Hsp40-J domain. Also provided is a method for enhancing cell transduction efficiency of a target agent, comprising conjugating/attaching said target agent with a recombinant polypeptide X—Y, wherein X is a cell penetrating peptide DPV3, and Y is an Hsp40-J domain. Further provided is a pharmaceutical composition comprising a therapeutic agent, wherein said therapeutic agent is modified by conjugating/attaching with a recombinant polypeptide X—Y, wherein X is a cell penetrating peptide DPV3, and Y is an Hsp40-J domain.

Abstract: A nebulizing device includes a medicament storage module, a nebulizing unit, and a first waterproof gasket. In the medicament storage module, a coupling part is connected with an outer surface of a tubular sidewall and aligned with an outlet of the tubular sidewall, and includes an extension wall and a first recess where the nebulizing unit is disposed. The first waterproof gasket is disposed within the first recess and located on a side of the nebulizing unit farther from the outlet. In the first waterproof gasket, a first opening is disposed adjacent to the nebulizing unit, a second opening is disposed opposite to the first opening and located on a side of the first opening farther from the nebulizing unit, the size of the second opening is greater than that of the first opening, and the annular wall structure is connected to the first opening and the second opening.

Abstract: A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15. Also provided is a composition comprising said synthetic peptide with a therapeutic agent fused thereto, and a pharmaceutically acceptable carrier or diluent. Further provided is a method of screening a peptide specifically targeting to a cancer stem cell. The method comprises the steps of establishing an oligopeptide library by using a phage expression system, contacting the library with a culture of bulk tumor cells of a cancer cell line, contacting the phages which do not bind to the bulk tumor cells with a culture of cancer stem cells of said cancer cell line, and screening a peptide specifically targeting to a cancer stem cell from the phages which bind to the cancer stem cells.

Abstract: In an instant messaging device, a selection is received from a user, where the selection specifying a plurality of contacts to participate in an instant messaging session. At least one attribute type corresponding to the at least one intended recipient is retrieved in response to detecting a trigger event relating to a message intended for at least one recipient among the plurality of contacts. A verification operation is retrieved for each of the retrieved at least one attribute type. At least one retrieved verification operations is executed. The message is sent to the at least one intended recipient in response to successful execution of the at least one of the retrieved verification operations.

Abstract: A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15. Also provided is a composition comprising said synthetic peptide with a therapeutic agent fused thereto, and a pharmaceutically acceptable carrier or diluent. Further provided is a method of screening a peptide specifically targeting to a cancer stem cell. The method comprises the steps of establishing an oligopeptide library by using a phage expression system, contacting the library with a culture of bulk tumor cells of a cancer cell line, contacting the phages which do not bind to the bulk tumor cells with a culture of cancer stem cells of said cancer cell line, and screening a peptide specifically targeting to a cancer stem cell from the phages which bind to the cancer stem cells.

Abstract: In an instant messaging device, a selection is received from a user, where the selection specifying a plurality of contacts to participate in an instant messaging session. At least one attribute type corresponding to the at least one intended recipient is retrieved in response to detecting a trigger event relating to a message intended for at least one recipient among the plurality of contacts. A verification operation is retrieved for each of the retrieved at least one attribute type. At least one retrieved verification operations is executed. The message is sent to the at least one intended recipient in response to successful execution of the at least one of the retrieved verification operations.

Abstract: The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

Abstract: Vaccine compositions for use in inducing enhanced antigen-specific T cell-mediated immune responses in a subject in need thereof are disclosed. The composition comprises (a) a therapeutically effective amount of an immunogenic protein comprising at least an antigen of a pathogen; (b) a saponin-base adjuvant selected from the group consisting of GPI-0100, Quil A, QS-21; and (c) a Toll-like receptor (TLR) agonist adjuvant selected from the group consisting of monophosphoryl lipid A (MPL), and CpG1826.

Abstract: A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15. Also provided is a composition comprising said synthetic peptide with a therapeutic agent fused thereto, and a pharmaceutically acceptable carrier or diluent. Further provided is a method of screening a peptide specifically targeting to a cancer stem cell. The method comprises the steps of establishing an oligopeptide library by using a phage expression system, contacting the library with a culture of bulk tumor cells of a cancer cell line, contacting the phages which do not bind to the bulk tumor cells with a culture of cancer stem cells of said cancer cell line, and screening a peptide specifically targeting to a cancer stem cell from the phages which bind to the cancer stem cells.

Abstract: An antioxidant conductive copper paste and a method for preparing the same are revealed. The antioxidant conductive copper paste includes conductive particles, a pasting agent, and a solvent. The conductive particles are copper nanoparticles or copper alloy nanoparticles. The pasting agent can be ethyl cellulose, Poly(3,4-ethylenedioxythiophene) (PEDOT), or epoxy. The solvent can be terpineol, ethylene glycol or diethylene glycol. The antioxidant conductive copper paste with features of high stability and low cost can be applied to produce electrodes of heterojunction solar cells.

Abstract: The present invention relates to an elastic pull rope used in exercise, comprising an inner tube layer with a hollow channel, a woven wire layer surrounding the outer part of the inner tube layer and an outer tube layer surrounding the outer part of the woven wire layer, wherein the woven wire layer surrounds the outer surface of the inner tube layer via a plurality of first wire rods, and weaving a plurality of second wire rods around the first wire rods in an overlapping manner in order to form and clamp the woven wire layer between the inner and outer tube layers, so that the formed elastic pull rope would have improved overall structural strength.

Abstract: A medical contrast agent made of microbubbles containing Au nanoclusters is provided. The shell of the microbubbles contains fluorescent Au nanocluster-albumin complex, and the core contains air or fluorocarbons. The method for preparing the microbubbles is also disclosed.

Abstract: The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

Abstract: Vaccine compositions for use in inducing enhanced antigen-specific T cell-mediated immune responses in a subject in need thereof are disclosed. The composition comprises (a) a therapeutically effective amount of an immunogenic protein comprising at least an antigen of a pathogen; (b) a saponin-base adjuvant selected from the group consisting of GPI-0100, Quil A, QS-21; and (c) a Toll-like receptor (TLR) agonist adjuvant selected from the group consisting of monophosphoryl lipid A (MPL), and CpG1826.

Abstract: A nebulizing device includes a medicament storage module, a nebulizing unit, and a first waterproof gasket. In the medicament storage module, a coupling part is connected with an outer surface of a tubular sidewall and aligned with an outlet of the tubular sidewall, and includes an extension wall and a first recess where the nebulizing unit is disposed. The first waterproof gasket is disposed within the first recess and located on a side of the nebulizing unit farther from the outlet. In the first waterproof gasket, a first opening is disposed adjacent to the nebulizing unit, a second opening is disposed opposite to the first opening and located on a side of the first opening farther from the nebulizing unit, the size of the second opening is greater than that of the first opening, and the annular wall structure is connected to the first opening and the second opening.

Abstract: The present invention relates to a scoring method for predicting the survival of a de novo AML patient based on the expression level of microRNAs mir-9, mir-155 and mir-203 in the patient. Patients with higher scores are associated with shorter overall survival. This scoring method is simple, powerful, and widely applicable for risk stratification of AML patients.

Abstract: The present invention provides a device for stimulating neural regeneration and/or neurite outgrowth and a fabrication method thereof. A photovoltaic component having a substrate, a first conductive layer, an active layer and a second conducting stacked in sequence is formed. The photovoltaic component is encapsulated by an encapsulant with a portion of the first conductive layer and the second conductive layer exposed from the encapsulant. The device is configured to be rolled to form a guiding tube having two open ends and to be placed at a damaged portion of a nerve. When the device is illuminated by light, a photovoltage exists between the first conductive layer and the second conductive layer for producing an electric current, so as to stimulate neural regeneration and repair the damaged portion of a nerve.

Abstract: A measuring device includes an audio collection module, an audio player module and a switch module. The audio player module electrically connects to the audio collection module, and the switch module electrically connects to the audio player module. The audio collection module collects sounds to generate an audio signal. The audio player module plays the audio signal. The switch module sets an enabling signal for controlling the audio player module. The enabling signal is set to be at either a first state or a second state different from the first state. When the enabling signal is at the first state, the audio player module plays the audio signal under a first output mode. When the enabling signal is at the second state, the audio player module plays the audio signal under a second output mode different from the first output mode.