Patents by Inventor Kai Bruning

Kai Bruning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030207892
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immuno-suppressant/immunomodulating actions.
    Type: Application
    Filed: April 1, 2003
    Publication date: November 6, 2003
    Inventors: Guillaume Lebaut, Cecilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune
  • Publication number: 20030195360
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents 1
    Type: Application
    Filed: December 4, 2002
    Publication date: October 16, 2003
    Applicant: ASTA Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jurgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Gunther, Kay Brune, Guillaume Le Baut
  • Publication number: 20030023093
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents 1
    Type: Application
    Filed: March 19, 2001
    Publication date: January 30, 2003
    Applicant: ASTA Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jurgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Gunther, Kay Brune, Guillaume Le Baut
  • Publication number: 20020161025
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immunosuppressant/immunomodulating actions.
    Type: Application
    Filed: January 30, 2002
    Publication date: October 31, 2002
    Inventors: Guillaume Lebaut, Cecilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune
  • Patent number: 6344467
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immunosuppressant/immunomodulating actions.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: February 5, 2002
    Assignee: ASTA Medica AG
    Inventors: Guillaume Lebaut, Cécilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune
  • Patent number: 6258815
    Abstract: The novel specific immunophilin ligands of the general formula I have an antiasthmatic and immunosuppressive action and are suitable for the preparation of drugs.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: July 10, 2001
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Dietmar Reichert, Bernhard Kutscher, Holger Bang, Kay Brune, Gerhard Quinkert, Hans-Günter Schaible
  • Patent number: 6251932
    Abstract: The invention relates to an immunophilin ligand of Formula I and having antiasthmatic, antiallergic, antirheumatic, immunosuppressant, antipsoriatic and neuroprotectant properties,
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: June 26, 2001
    Assignee: ASTA Medica AG
    Inventors: Dietmar Reichelt, Berhard Kutscher, István Szelényi, Hildegard Poppe, Gerhard Quinkert, Kay Brune, Holger Bang, Holger Deppe
  • Patent number: 6232327
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: May 15, 2001
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jürgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Günther, Kay Brune
  • Patent number: 6180637
    Abstract: The invention relates to 1,2,5-trisubstituted 1,2-dihydroindazol-3-ones of formula (I) wherein X is —SO2—, —SO—, —(CH2)p—, —(CH2)p—O—, —(CH2)p—(C═O)—, —(CH2)p—(C═O)—NH—, —(CH2)p—CHOH—, —CHOH—(CH2)p—, —(CH2)p—CH═CH—, —CH═CH—(CH2)p—, Y is —(C═O)—, —(C═O)—NH—, —(C═O)—NH—(CH2)p—, —C═O)—(CH2)p—, —(CH2)p—, —(CH2)p—O—, —(CH2)p—(C═O)—, —(CH2)p—(C═O)—NH—, —(CH2)p—(C═O)—NH—(CH2)p—, —(CH2)p—CHOH—, —CHOH—(CH2)p—, —(CH2)p—CH═CH—, —CH═CH—(CH2)p—, Z is —O—, —O—(CH2)p—, —NH—, —NH—(
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: January 30, 2001
    Assignee: Arzneimittelwerk Dresden GmbH
    Inventors: Rudolf Schindler, Norbert Höfgen, Hildegard Poppe, Kay Brune
  • Patent number: 6166023
    Abstract: The invention relates to 1,5- and 3-O-substituted 1H-indazoles of formula (I) ##STR1##
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: December 26, 2000
    Assignee: Arzneimittelwerk Dresden GmbH
    Inventors: Rudolf Schindler, Norbert Hofgen, Hildegard Poppe, Kay Brune
  • Patent number: 6066465
    Abstract: A method is provided for detecting shock by measuring the concentration of cyclophilins in a patient's blood and comparing the measured concentration against a control. The severity of shock is then evaluated, an increase in cyclophilin concentrations over control levels being associated with severity. Measuring methods include enzymological techniques, such as rotomase activity assay; immunological procedures, such as radioimmunoassay and ELISA; peptide chemical processes, such as affinity chromatography; and radiochemical approaches, such as contacting the sample with radioactive cyclosporin.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: May 23, 2000
    Assignee: Paz Arzneimittel-Entwicklungsgesellschaft mbH
    Inventors: Holger Bang, Kay Brune, Albrecht Wendel, Gesa Tiegs
  • Patent number: 6008231
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immuno-suppressant/immunomodulating actions.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: December 28, 1999
    Assignee: ASTA Medica Aktiengesellschgt
    Inventors: Guillaume Lebaut, Cecilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune
  • Patent number: 5565613
    Abstract: The present invention concerns a process for the production of compositions of 2-arylpropionic acid derivatives with improved tablettability which contain per se known adjuvant and/or carrier materials, whereby the arylpropionic acid is mixed with a calcium compound and, after addition of the remaining adjuvant and/or carrier materials, is pressed to tablets, as well as pharmaceutical compositions produced therewith.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: October 15, 1996
    Assignee: Pharmatrans Sanaq AG
    Inventors: Gerd Geisslinger, Kay Brune, Kurt Bauer, Anton S. Huber
  • Patent number: 5206029
    Abstract: The present invention provides a medicament for the treatment of painful and/or inflammatory diseases and/or of fever with flurbiprofen, wherein the previously separated enantiomers of flurbiprofen are worked up in a ratio of 99.5-0.5% to 0.5-99.5%, in combination with conventional pharmaceutical carriers and adjuvants, to give a medicament.
    Type: Grant
    Filed: May 16, 1991
    Date of Patent: April 27, 1993
    Assignee: PAZ Arzneimittel-Entwicklungsgesellschaft mbH
    Inventors: Gerd Geisslinger, Kay Brune
  • Patent number: 5200198
    Abstract: The present invention provides a medicament for the treatment of painful and/or inflammatory diseases and/or of fever with flurbiprofen, wherein the flurbiprofen is pure or preponderantly R(-)-flurbiprofen worked up in combination with conventional pharmaceutical carriers and adjuvants, to give a medicament.
    Type: Grant
    Filed: May 16, 1991
    Date of Patent: April 6, 1993
    Assignee: Paz Arzneimittel-Entwicklungsgesellschaft mbH
    Inventors: Gerd Geisslinger, Kay Brune
  • Patent number: 4851443
    Abstract: Amide derivatives of non-steroidal anti-inflammatory carboxylic acids which have anti-inflammatory activity in their own right as well as being effective as pro-drugs of the carboxylic acids.
    Type: Grant
    Filed: July 5, 1988
    Date of Patent: July 25, 1989
    Assignee: Smith Kline Dauelsberg, GmbH
    Inventor: Kay Brune
  • Patent number: 4783487
    Abstract: Amide derivatives of non-steroidal anti-inflammatory carboxylic acids which have anti-inflammatory activity in their own right as well as being effective as pro-drugs of the carboxylic acids.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: November 8, 1988
    Assignee: Smith Kline Dauelsberg GmbH
    Inventor: Kay Brune
  • Patent number: 4732986
    Abstract: Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent, independently of one another, a hydrogen atom, a halogen atom, a linear C.sub.1 -C.sub.3 -alkyl group or a linear C.sub.1 -C.sub.3 -alkoxy group, R.sup.5 represents a hydrogen atom or a linear C.sub.1 -C.sub.3 -alkyl group, R.sup.6 represents a hydrogen atom, and R.sup.7 represents a formyl group, a carbalkoxy group of the formula ##STR2## wherein R.sup.8 denotes a linear or branch chained C.sub.1 -C.sub.4 -alkyl group, or it represents an acyl group of the formula ##STR3## wherein R.sup.9 denotes a linear C.sub.1 -C.sub.3 -alkyl group, or R.sup.6 and R.sup.7 together represent the group ##STR4## wherein R.sup.10 and R.sup.11 represent, independently of one another, a hydrogen atom or a linear C.sub.1 -C.sub.6 -alkyl group or R.sup.6 and R.sup.7 represent the group ##STR5## wherein R.sup.12 and R.sup.13 represent, independently of one another, a linear C.sub.1 -C.sub.
    Type: Grant
    Filed: May 12, 1987
    Date of Patent: March 22, 1988
    Assignee: Ludwig Heumann & Co. GmbH
    Inventors: Kay Brune, Heidrun Engler, Istvan Szelenyi, Peter Morsdorf, Helmut Schickaneder, Kurt H. Ahrens
  • Patent number: 4600721
    Abstract: Pharmaceutical preparations having an antiphlogistic action are described. The preparations contain, as active ingredient, a benzazole derivative corresponding to the general tautomeric formulae I ##STR1## wherein X represents a sulphur or oxygen atom and R.sup.1 represents a hydrogen atom and R.sup.2 a hydroxymethyl, formyl, lower carbalkoxy or lower acyl group or R.sup.1 and R.sup.2 together represent the group ##STR2## wherein R.sup.3 and R.sup.4 denote, independently of one another, a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl group, or they contain a physiologically acceptable salt thereof. These pharmaceutical preparations are suitable in particular for the treatment of inflammatory conditions and for inhibiting the lipoxygenase and/or cyclooxygenase route of arachidonic acid metabolism.
    Type: Grant
    Filed: March 27, 1985
    Date of Patent: July 15, 1986
    Assignee: Ludwig Heumann & Co., GmbH
    Inventors: Peter Morsdorf, Helmut Schickaneder, Heidrun Engler, Istvan Szelenyi, Kurt H. Ahrens, Kay Brune