Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a neural network having a plurality of sub neural networks to assign respective confidence scores to one or more candidate future trajectories for an agent. Each confidence score indicates a predicted likelihood that the agent will move along the corresponding candidate future trajectory in the future. In one aspect, a method includes using the first sub neural network to generate a training intermediate representation; using the second sub neural network to generate respective training confidence scores; using a trajectory generation neural network to generate a training trajectory generation output; computing a first loss and a second loss; and determining an update to the current values of the parameters of the first and second sub neural networks.

Abstract: One or more embodiments of the disclosure include a digital merchant content system that creates one or more custom merchant content interfaces. In particular, in one or more embodiments, the digital merchant content system generates custom merchant content interfaces based on a custom merchant content template. The digital merchant content system can generate custom merchant content templates comprising unpopulated product display layouts. Moreover, in one or more embodiments, the digital merchant content system receives a product feed and generates a custom merchant content interface by populating the unpopulated product display layouts based on the custom merchant content template and the product feed.

Abstract: The present disclosure discloses a method for expressing and preparing a bivalent bispecific antibody. In the present disclosure, each portion of a bivalent bispecific antibody and an immune hybrid protein thereof is respectively expressed in a suitable prokaryotic or eukaryotic cell system, separated and purified by high-performance affinity chromatography, and then spliced in vitro by trans-splicing reaction mediated by an intein, to prepare the bivalent specific antibody and an immune hybrid protein thereof.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium that generates path prediction data for agents in the vicinity of an autonomous vehicle using one or more machine learning models. One of the methods includes identifying an agent in a vicinity of an autonomous vehicle navigating through an environment and determining that the agent is within a vicinity of a crossing zone across a roadway. The crossing zone can be a marked crossing zone or an unmarked crossing zone. For example, the crossing zone can be an unmarked crossing zone that has been identified based on previous observations of agents crossing the roadway.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for predicting near-curb driving behavior. One of the methods includes obtaining agent trajectory data for an agent in an environment, the agent trajectory data comprising a current location and current values for a predetermined set of motion parameters of the agent; processing a model input generated from the agent trajectory data using a trained machine learning model to generate a model output comprising a prediction of whether the agent will exhibit near-curb driving behavior within a predetermined timeframe, wherein an agent exhibits near-curb driving behavior when the agent operates within a particular distance of an edge of a road in the environment; and using the prediction to generate a planned path for a vehicle in the environment.

Abstract: The technology relates to controlling a vehicle in an autonomous driving mode in accordance with behavior predictions for other road users in the vehicle's vicinity. In particular, the vehicle's onboard computing system may predict whether another road user will perform a “continuing” lane driving operation, such as going straight in a turn-only lane. Sensor data from detected/observed objects in the vehicle's nearby environment may be evaluated in view of one or more possible behaviors for different types of objects. In addition, roadway features, in particular whether lane segments are connected in a roadgraph, are also evaluated to determine probabilities of whether other road users may make an improper continuing lane driving operation. This is used to generate more accurate behavior predictions, which the vehicle can use to take alternative (e.g., corrective) driving actions.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining respective importance scores for a plurality of agents in a vicinity of an autonomous vehicle navigating through an environment. The respective importance scores characterize a relative impact of each agent on planned trajectories generated by a planning subsystem of the autonomous vehicle. In one aspect, a method comprises providing different states of an environment as input to the planning subsystem and obtaining as output from the planning subsystem corresponding planned trajectories. Importance scores for the one or more agents that are in one state but not in the other are determined based on a measure of difference between the planned trajectories.

Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating candidate future trajectories for agents. One of the methods includes obtaining scene data characterizing a scene in an environment at a current time point; for each of a plurality of lane segments, processing a model input comprising (i) features of the lane segment and (ii) features of the target agent using a machine learning model that is configured to process the model input to generate a respective score for the lane segment that represents a likelihood that the lane segment will be a first lane segment traversed by the target agent after the current time point; selecting, as a set of seed lane segments, a proper subset of the plurality of lane segments based on the respective scores; and generating a plurality of candidate future trajectories for the target agent.

Abstract: To operate an autonomous vehicle, a rail agent is detected in a vicinity of the autonomous vehicle using a detection system. One or more tracks are determined on which the detected rail agent is possibly traveling, and possible paths for the rail agent are predicted based on the determined one or more tracks. One or more motion paths are determined for one or more probable paths from the possible paths, and a likelihood for each of the one or more probable paths is determined based on each motion plan. A path for the autonomous vehicle is then determined based on a most probable path associated with a highest likelihood for the rail agent, and the autonomous vehicle is operated using the determined path.

Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for performing knowledge distillation for autonomous vehicles. One of the methods includes obtaining sensor data characterizing an environment, wherein the sensor data has been captured by one or more sensors on-board a vehicle in the environment; processing, for each of one or more surrounding agents in the environment, a network input generated from the sensor data using a neural network to generate an agent discomfort prediction that characterizes a level of discomfort of the agent; combining the one or more agent discomfort predictions to generate an aggregated discomfort score; and providing the aggregated discomfort score to a path planning system of the vehicle in order to generate a future path of the vehicle.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for identifying high-priority agents in the vicinity of a vehicle. The high-priority agents can be identified based on a set of mutual importance scores in which each mutual importance score indicates an estimated mutual relevance between the vehicle and a different agent from a set of agents on planning decisions of the other. The mutual importance scores can be calculated based on importance scores assessed from the perspectives of both the vehicle and the agents.

Abstract: Methods, computer systems, and apparatus, including computer programs encoded on computer storage media, for training a mixture of a plurality of actor-critic policies that is used to control an agent interacting with an environment to perform a task. Each actor-critic policy includes an actor policy and a critic policy. The training includes, for each of one or more transitions, determining a target Q value for the transition from (i) the reward in the transition, and (ii) an imagined return estimate generated by performing one or more iterations of a prediction process to generate one or more predicted future transitions.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a task schedule for generating prediction data for different agents. In one aspect, a method comprises receiving data that characterizes an environment in a vicinity of a vehicle at a current time step, the environment comprising a plurality of agents; receiving data that identifies high-priority agents for which respective data characterizing the agents must be generated at the current time step; identifying available computing resources at the current time step; processing the data that characterizes the environment using a complexity scoring model to determine a respective complexity score for each of the high-priority agents; and determining a schedule for the current time step that allocates the generation of the data characterizing the high-priority agents across the available computing resources based on the complexity scores.

Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.

Abstract: Jaywalking behaviors of vulnerable road users (VRUs) such as cyclists or pedestrians can be predicted. Location data is obtained that identifies a location of a VRU within a vicinity of a vehicle. Environmental data is obtained that describes an environment of the VRU, where the environmental data identifies a set of environmental features in the environment of the VRU. The system can determine a nominal heading of the VRU, and generate a set of predictive inputs that indicate, for each of at least a subset of the set of environmental features, a physical relationship between the VRU and the environmental feature. The physical relationship can be determined with respect to the nominal heading of the VRU and the location of the VRU. The set of predictive inputs can be processed with a heading estimation model to generate a predicted heading offset (e.g., a target heading offset) for the VRU.

Abstract: Aspects of the disclosure provide for controlling a vehicle in an autonomous driving mode. For instance, sensor data for an object as well as a plurality of predicted trajectories may be received. Each predicted trajectory may represent a plurality of possible future locations for the object. A grid including a plurality of cells, each being associated with a geographic area, may be generated. Probabilities that the object will enter the geographic area associated with each of the plurality of cells over a period of time into the future may be determined based on the sensor data in order to generate a heat map. One or more of the plurality of predicted trajectories may be compared to the heat map. The vehicle may be controlled in the autonomous driving mode based on the comparison.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for determining occupancies of surrounding agents. One of the methods includes obtaining scene data characterizing an environment at a current time point; processing a first network input generated from the scene data using a first neural network to generate an intermediate output; obtaining an identification of a future time point that is after the current time point; and generating, from the intermediate output and the future time point, an occupancy output, wherein the occupancy output comprises respective occupancy probabilities for each of a plurality of locations in the environment, wherein the respective occupancy probability for each location characterizes a likelihood that one or more agents will occupy the location at the future time point.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for identifying high-priority agents in the vicinity of a vehicle and, for only those agents which are high priority agents, generating data characterizing the agents using a first prediction model. In a first aspect, a system identifies multiple agents in an environment in a vicinity of a vehicle. The system generates a respective importance score for each of the agents by processing a feature representation of each agent using an importance scoring model. The importance score for an agent characterizes an estimated impact of the agent on planning decisions generated by a planning system of the vehicle which plans a future trajectory of the vehicle. The system identifies, as high-priority agents, a proper subset of the plurality of agents with the highest importance scores.