Abstract: A power device includes a mainboard and a power conversion module. The mainboard includes a first side and a third side opposite each other along a first direction, a second side and a fourth side opposite each other along a second direction, the first direction is perpendicular to the second direction. The power conversion module includes a primary-side circuit board and a secondary-side module. The secondary-side module includes a secondary-side circuit board, and the primary-side circuit board, the mainboard and the secondary-side circuit board being electrically connected, the primary-side circuit board and the secondary-side circuit board are spatially separated. The secondary-side module further includes secondary-side element and a first magnetic core element, wherein the secondary-side element and the first magnetic core element are disposed on the secondary-side circuit board along a third direction perpendicular to the first direction and the second direction.

Abstract: A power supply device includes a main circuit board. The main circuit board includes a first side, a second side, a third side and a fourth side. The first side and the second side are opposed to each other and extended in a first direction. The third side and the fourth side are opposed to each other and extended in a second direction. An input/output module is located adjacent to the fourth side. A capacitor module is located adjacent to the third side. A rectifier module is disposed on the main circuit board. A rectifier module is arranged between the input/output module and the capacitor module and located adjacent to the input/output module. A first inductor module, a resonant module and a power semiconductor device module are disposed on the main circuit board and arranged between the capacitor module and the rectifier module.

Abstract: The present disclosure provides a monitoring method for monitoring a DC bus capacitor, including steps of: in a preset cycle, sampling an input voltage, an input current and an output voltage to obtain an input power; filtering the input power and the output voltage to obtain an AC component of the input power and an AC component of the output voltage; calculating a capacitance according to the DC component of the output voltage, the AC component of the input power and the AC component of the output voltage; obtaining a total weight coefficient corresponding to the capacitance; and outputting a monitoring capacitance of the DC bus capacitor according to the plurality of the capacitance calculated and obtained in a plurality of the preset cycles and the plurality of the total weight coefficients corresponding to the plurality of capacitance.

Abstract: The present disclosure provides a pharmaceutical composition for treating sepsis and use thereof, belonging to the technical field of chemical drugs. The present disclosure provides a three-component pharmaceutical composition including hydroxysafflower yellow A (HSYA), paeoniflorin, and albiflorin. The present disclosure further provides a seven-component pharmaceutical composition including HSYA, paeoniflorin, albiflorin, oxypaeoniflorin, senkyunolide I, salvianic acid A sodium (SAAS), and ferulic acid. In the present disclosure, it is verified at the cell level and the animal level that both two groups of the pharmaceutical compositions have an efficacy of effectively treating sepsis. Meanwhile, drug toxicity experiments show that the two groups of the pharmaceutical compositions both are safe. The pharmaceutical composition is an active ingredient of the Xuebijing Injection, which can be used for the clinical treatment of sepsis.

Abstract: A multi-level power factor correction circuit and a surge protection control method for the multi-level power factor correction circuit are provided. When an input voltage is in the surge condition, the multi-level power factor correction circuit enters a surge protection mode under control of a control unit. In the surge protection mode, two first switches, two second switches, a first polarity switch and a second polarity switch are maintained in the turn-off state. Consequently, the input current of the multi-level power factor correction circuit will not flow through the flying capacitor. Since the voltage on the flying capacitor is very stable and not over-charged, the security of the multi-level power factor correction circuit is enhanced.

Abstract: A power supply device, a power supply control device and a control method thereof are provided. The power supply control device is electrically connected to a power source configured to provide power to a post-stage circuit of the power supply control device, and the power supply control device includes a current limiting module and a control unit. The current limiting module is electrically connected to the power source and the post-stage circuit and includes first and second current limiting units electrically connected in parallel. The first current limiting unit is configured to limit an inrush current generated during startup of the post-stage circuit, and the second current limiting unit is configured to limit an inrush current generated during a fluctuation of the power source. The control unit is electrically connected to the current limiting module and is configured to control the first and second current limiting units.

Abstract: A control method for flying capacitor voltage and multi-level conversion circuit employing same are provided. In the multi-level conversion circuit, all lower switches are connected in series between an inductor and a negative output terminal, and all upper switches are connected in series between the inductor and a positive output terminal. Every flying capacitor is connected between a common connection node of the lower switches and a common connection node of the upper switches. When working in DCM, the control method includes steps of (a) regarding the lower switches and the upper switches as main switches and synchronous rectification switches, and (b) adjusting duty ratios of driving signals of the main switches according to adjustment values corresponding to the flying capacitors connected thereto, and adjusting phase-shift angles between driving signals of any two neighboring main switches according to the acquired adjustment values.

Abstract: The present disclosure provides a ribose-modified cap analog and a use thereof, and belongs to the technical field of chemical and biological engineering. The ribose-modified cap analog has a structure of formula (I). The ribose-modified cap analog described herein can improve the stability of mRNA and/or the translation efficiency of mRNA.

Abstract: A power module and an auxiliary supporting device adapted thereto are provided. The auxiliary supporting device is used to maintain a first circuit board in a vertical state on a second circuit board. The auxiliary supporting device includes a first plate and a second plate. The first plate is parallel to and fixed to the first circuit board. The second plate is extended from the first plate in a direction away from the first circuit board. A bottom edge of the second plate is disposed on a surface of the second circuit board facing the first circuit board. The auxiliary supporting device is universally suitable for different combinations between the first plate and the second plate without the need of customized tool.

Abstract: An isolated DC-DC converter including n conversion circuit units is provided. In each conversion circuit unit, a first connection node is formed between two switching components of a first primary bridge arm, and a second connection node is formed between two electronic components of a second primary bridge arm. A third connection node is formed between two switching components of a first secondary bridge arm, and a fourth connection node is formed between two switching components of a second secondary bridge arm. A first coupling inductor and A first capacitor are serially coupled between the first and third connection nodes. A second coupling inductor and a second capacitor are serially coupled between the second and fourth connection nodes. In the n conversion circuit units, the primary circuit units are electrically connected in series or in parallel, and the secondary circuit units are electrically connected in parallel or in series correspondingly.

Abstract: A power supply device is disclosed and includes a transformer unit, a rectifier unit and a heat dissipation component. The transformer unit includes a first winding, a second winding and a magnetic core. The rectifier unit includes a circuit board, a plurality of rectifiers and a plurality of output filter capacitors. The circuit board and the transformer unit are disposed adjacent to each other, and the second winding is electrically connected to the circuit board, wherein the circuit board has a first side and a second side opposite to each other, and the first side faces the transformer unit. The heat dissipation component covers a rectification module formed by the transformer unit and the rectifier unit.

Abstract: A knee joint mechanism includes a thigh support assembly, a connecting base, a shank support assembly and a locking mechanism. The thigh support assembly is fixed at a thigh of an exoskeleton robot, a first angle sensor is disposed on a hip, and power is provided from the hip. The connecting base is mounted with a second angle sensor. The locking mechanism includes a motor, a worm gear assembly, a locking member, an unlocking member, and a first limiting member. The unlocking member and the first limiting member firmly fix the locking member to maintain the thigh support assembly, the connecting base and the shank support assembly at an ergonomic angle. The motor drives the unlocking member to rotate through the worm gear assembly to realize unlocking. The second angle sensor controls the unlocking member to lock the locking block.

Abstract: A computing system is provided. The computing system includes a load module, a power supply module and first horizontal busbars. The power supply module is configured to supply power to the load module, and includes power supply units arranged along a vertical direction. Each of the power supply units includes power supply subunits, and the power supply units are electrically connected through at least one power distribution busbar. Each first horizontal busbar is extended along a horizontal direction. The first horizontal busbars are configured to electrically connect the power supply units with the load module. The horizontal direction is perpendicular to the vertical direction. When any of the power supply units fails, the load module receives power from another one of the power supply units through a corresponding first horizontal busbar and a corresponding power distribution busbar.

Abstract: The present disclosure provides a C6?-substituted locked nucleic acid-modified cap analog and a use thereof, wherein the cap analog improves the stability of mRNA and/or the translation efficiency of mRNA.

Abstract: Provided in the present disclosure is a compound of formula (I), or an N-oxide, solvate, pharmaceutically acceptable salt or stereoisomer thereof, which is an extrahepatic targeted cationic lipid compound with high efficiency and low toxicity. Further provided are a composition containing the aforementioned compound, and the use thereof in the delivery of a therapeutic or prophylactic agent.

Abstract: In the present disclosure, the multi-level AC/DC conversion circuit and the multi-level DC/DC conversion circuit calculate the duty ratio of synchronous rectification switch according to the input voltage, the output voltage, the interval time of turning on the main switch, the switching cycle and the duty ratio of main switch, thereby eliminating the need for additional zero-current detecting function or zero-crossing detection circuit in conventional AC/DC conversion circuits. Accordingly, for the multi-level AC/DC conversion circuit and the multi-level DC/DC conversion circuit of the present disclosure, the cost is reduced, and the reliability is enhanced.

Abstract: The present disclosure belongs to the technical field of mRNA vaccines, and particularly relates to a respiratory syncytial virus (RSV) vaccine, and a preparation method therefor and use thereof. The vaccine provided by the present disclosure comprises RNA encoding an RSV F protein or a variant thereof. The vaccine can prevent an RSV infection and complications thereof.

Abstract: The present disclosure belongs to the technical field of mRNA vaccines, and particularly relates to a respiratory syncytial virus (RSV) vaccine, and a preparation method therefor and use thereof. The vaccine provided by the present disclosure comprises RNA encoding an RSV F protein or a variant thereof. The vaccine can prevent an RSV infection and complications thereof.

Abstract: A multi-level conversion circuit and a control method for flying capacitor voltage thereof are provided. In the multi-level conversion circuit, each flying capacitor is connected between a common connection node of the lower switches connected therewith and a common connection node of the upper switches connected therewith. The control method includes steps of: (a) determining the main switch and synchronous rectification switch of the lower and upper switches; (b) acquiring an adjustment value corresponding to each flying capacitor; (c) adjusting a duty ratio of the main switch according to the adjustment value corresponding to the flying capacitor connected therewith; and (d) when the multi-level conversion circuit working in a CCM, increasing a phase-shift angle between the main switches by an angle to make a peak value or a valley value of an inductor current remain unchanged before and after adjusting the duty ratio.

Abstract: The present disclosure provides a three-phase resonant converter, including: a primary switching unit, including three primary switching bridge arms, wherein each primary switching bridge arm includes a first primary switch and a second primary switch, and a bridge arm midpoint formed between the first primary switch and the second primary switch; a voltage conversion unit, including three primary windings and three secondary windings, wherein a first terminal of each primary winding is electrically connected to the bridge arm midpoint of the corresponding primary switching bridge arm, and second terminals of the three primary windings are electrically connected to a common node; a resonant unit, including three resonant circuits; a secondary rectifier unit, including three rectifier circuits; and at least one bypass capacitor, electrically connected between the common node and an input terminal of the primary switching unit.