Abstract: A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period.

Abstract: A method and system for use in measuring the endothelial dysfunction in a patient utilizing flow mediated dilation. The system includes both a non-invasive blood pressure monitor and an ultrasound system that communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer and blood pressure cuff are positioned on an arm of the patient and the blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining both the diameter of the artery and the flow rate of blood through the artery without any operator intervention. Based upon the detected characteristics of the artery before and after occlusion, the system can determine the endothelial dysfunction of the patient.

Abstract: An ultrasonic transducer probe having a highly integrated interface circuit array. Low-voltage transmit control signals from the system are transmitted on the system transmit channels via the ultrasound probe cable and into the interface circuit array. These transmit control signals are routed through the interface circuit array using a dense switching matrix. Once the low-voltage transmit control signals reach individual cells within the interface array, they are decoded and used to control local high-voltage pulser circuits to drive individual ultrasound transducer elements made up of selected subelements that are co-integrated with the interface electronics. The interface cell circuitry further comprises a high-voltage transmit/receive switch, which is closed when the high-voltage pulser is transmitting to protect the low-voltage components.

Abstract: A continuous, non-invasive fetal heart rate measurement is produced using one or more ultrasonic transducer array patches that are adhered or attached to the mother. Each ultrasound transducer array is operated in an autonomous mode by a digital signal processor to obtain data from which fetal heart rate information can be derived. Each ultrasonic transducer array patch comprises a multiplicity of subelements that are switchably reconfigurable to form elements having different shapes, e.g., annular rings. Each subelement comprises a plurality of interconnected cMUT cells that are not switchably disconnectable. The use of cMUT patches will provide the ability to interrogate a three-dimensional space electronically (i.e. without mechanical beam steering) with ultrasound, using a transducer device that is thin and lightweight enough to stick to the patient's skin like an EKG electrode.

Abstract: A continuous, non-invasive fetal heart rate measurement is produced using one or more ultrasonic transducer array patches that are adhered or attached to the mother. Each ultrasound transducer array is operated in an autonomous mode by a digital signal processor to obtain data from which fetal heart rate information can be derived. Each ultrasonic transducer array patch comprises a multiplicity of subelements that are switchably reconfigurable to form elements having different shapes, e.g., annular rings. Each subelement comprises a plurality of interconnected cMUT cells that are not switchably disconnectable. The use of cMUT patches will provide the ability to interrogate a three-dimensional space electronically (i.e. without mechanical beam steering) with ultrasound, using a transducer device that is thin and lightweight enough to stick to the patient's skin like an EKG electrode.

Abstract: A method and system for use in measuring the endothelial dysfunction in a patient utilizing flow mediated dilation. The system includes both a non-invasive blood pressure monitor and an ultrasound system that communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer and blood pressure cuff are positioned on an arm of the patient and the blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining both the diameter of the artery and the flow rate of blood through the artery without any operator intervention. Based upon the detected characteristics of the artery before and after occlusion, the system can determine the endothelial dysfunction of the patient.

Abstract: A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period.

Abstract: The reconfigurable ultrasound array disclosed herein is one that allows groups of subelements to be connected together dynamically so that the shape of the resulting element can be made to match the shape of the wave front. This can lead to improved performance and/or reduced channel count. Reconfigurability can be achieved using a switching network. A methodology and an algorithm are disclosed that allows the performance of this switching network to be improved by properly choosing the configuration of the switching network.

Abstract: An integrated switch matrix for reconfiguring subelements of a mosaic sensor array to form elements. The configuration of the switch matrix is fully programmable. The switch matrix includes access switches that connect subelements to bus lines and matrix switches that connect subelements to subelements. Each subelement has a unit switch cell comprising at least one access switch, at least one matrix switch, a respective memory element for storing the future state of each switch, and a respective control circuit for each switch. The access and matrix switches are of a type having the ability to memorize control data representing the current switch state of the switch, which control data includes a data bit input to turn-on/off circuits incorporated in the control circuit. The sensor array and the switching matrix may be built in different strata of a co-integrated structure or they may be built on separate wafers that are electrically connected.

Abstract: Ultrasound is used to provide input data for a blood pressure estimation scheme. The use of transcutaneous ultrasound provides arterial lumen area and pulse wave velocity information. In addition, ultrasound measurements are taken in such a way that all the data describes a single, uniform arterial segment. Therefore a computed area relates only to the arterial blood volume present. Also, the measured pulse wave velocity is directly related to the mechanical properties of the segment of elastic tube (artery) for which the blood volume is being measured. In a patient monitoring application, the operator of the ultrasound device is eliminated through the use of software that automatically locates the artery in the ultrasound data, e.g., using known edge detection techniques. Autonomous operation of the ultrasound system allows it to report blood pressure and blood flow traces to the clinical users without those users having to interpret an ultrasound image or operate an ultrasound imaging device.

Abstract: A method for generating an image of an object of interest includes acquiring a first three-dimensional dataset of the object at a first position using an X-ray source and a detector, acquiring a second three-dimensional dataset of the object at the first position using an ultrasound probe, and combining the first three-dimensional dataset and the second three-dimensional dataset to generate a three-dimensional image of the object.

Abstract: A method and an apparatus for adaptively suppressing incoherent data in a coherent imaging system. A focused ultrasound beam is transmitted with conventional transmit beamforming time delays. The returning echo signals are processed along two separate receive signal processing paths. The time delays along one processing path are set for traditional coherent receive beamforming, while the time delays along the other processing path are set to apply incoherent summing to the same set of return signals (e.g., time delays equal to zero). Then at each point in the receive beam or vector, the coherent and incoherent summation signals are compared. If the coherent and incoherent summation signals are of like amplitude, the beamformed signal of the first processing path is deemed incoherent, and its display is suppressed in the final image.

Abstract: A method and apparatus for high-speed ultrasonic imaging of very rapidly moving bodily structures. A transducer produces sequential data frames corresponding to sequential images of bodily cross-sections produced by periodically scanning a body with an ultrasound beam produced by the transducer. Reflected ultrasonic echo pulses are digitized and stored in a memory array in which each data frame is stored in a single segment of a plurality of memory segments which form the memory. The transducer periodically scans the body at a predetermined first rate, whereas the sequential display of the sequential data frames occurs at a second predetermined rate which is different from the first rate. The system permits acquisition of data at a rate which is greater than the perception rate of the human eye and display of the acquired data at a rate which can be visualized by a human observer.

Abstract: Circuitry for generating a distortion-free sector display in a cathode ray tube for displaying signals from an ultrasonic transducer moving back and forth in an arcuate path. Sine and cosine beam sweep signals are developed using signals respectively representing the angular position .theta. of the transducer on its angular path (representing the sine) and 1-.theta..sup.2 /2(representing the cosine). A transducer position signal is stored on a relatively large capacitor, and a capacitor of smaller capacitance is used to generate a ramp signal in producing the sine and cosine beam sweep signals.

Abstract: An electronically scanned phased array diagnostic system for describing internal structure of a subject by the use of ultrasonic energy. The system includes a transducer unit with an array of ultrasonic energy conversion segments and control circuitry for actuating the segments to direct ultrasonic energy into the subject. Imaging circuitry is included for interpreting electrical return signals produced by the segments in response to ultrasonic echoes. The imaging circuitry includes transmission delay circuits for imposing time delays on the return signals for steering and focusing system echo reception. Each transmission delay circuit includes first and second delay elements for impressing first and second delay time components on the return signals. Each pair of the first delay elements are coupled in parallel with separate transducer elements, and serially combined with a downstream second delay element.The first delay elements provide a portion of the reception steering capability.