Abstract: Provided are an arginine deiminase mutant, a covalent dimer and a conjugate and a use thereof. The provided arginine deiminase mutant forms a covalent disulfide bond between arginine deiminase subunits by means of mutation of an amino acid site on arginine deiminase. Also provided are a covalent conjugate and a use in the field of cancer treatment. Site-directed mutagenesis of an amino acid site promotes formation of a covalent disulfide bond between non-covalent homodimeric arginine deiminase subunits, and a formed dimer has a more stable structure; in addition, the exposure level of an epitope on an interaction interface can be reduced, the in vivo immunogenicity is reduced, and a more excellent anti-tumor effect is exhibited.

Abstract: Provided is a method for improving the stability of urate oxidase. The inventors have discovered that combining an active ingredient urate oxidase or chemically modified urate oxidase with a stabilizer xanthine through a non-covalent bond can significantly improve the in vivo and in vitro stability of urate oxidase and chemically modified urate oxidase in the form of a tetramer, thereby effectively improving the stability of urate oxidase.

Abstract: Methods and systems are provided for implementing quality estimation for automatic speech recognition, and more specifically training an ASR model, and training a QE model to perform word error rate prediction upon the trained ASR model. The ASR model may be a transformer learning model having an architecture including an encoder including multi-head attention layers, and a memory encoder including a masking multi-head attention layer. The QE model may include a binary classification model and a regression model, where the binary classification model is based on a discrete statistical distribution, and the regression model is based on a continuous statistical distribution. Training the ASR model may produce output having variable word error rates, and the QE model may be trained based on empirical word error rates of the ASR model. The QE model may predict performance of the ASR model without labor-intensive labeling to generate ground truth.

Abstract: A solar cell includes a solar cell body, a plurality of fingers, and a plurality of first interconnection structures. At least a part of regions of different first interconnection structures distributed at intervals along a second direction are collinear with a same connection line of a plurality of connection lines. A quantity of connection lines located on the same target surface is N1, a quantity of first interconnection structures intersecting with a target line segment located on the target surface is N2, and N2<½N1. The target line segment is a connection line segment between a midpoint of an edge that has a larger length in two edges of the target surface extending along a first direction and being arranged opposite to each other and a vertex-angle endpoint corresponding to an edge that has a smaller length in the two edges.

Abstract: This application discloses an application icon management method and an electronic device, and relates to the field of terminal technologies. The method includes: displaying a first interface on a display; displaying a second interface when detecting a first operation for a first application icon on the first interface, where a display parameter of the first application icon on the second interface is better than a display parameter of another application icon on the second interface; in response to a second operation for the first application icon on the second interface, controlling the first application icon to move on the second interface; and exchanging positions of the first application icon and a second application icon when the first application icon moves to a specified position of the second application icon on the second interface and a moving speed of the first application icon is lower than a preset moving speed threshold.

Abstract: Example icon moving methods and apparatus are described. In one example, an electronic device displays a first number of application icons. The electronic device detects a first user operation including selecting a first application icon, and displays a second number of application icons in response to the first user operation. The electronic device detects a second user operation of releasing the first application icon, and changes an arrangement of the first application icon to a second location.

Abstract: An FPGA-based USB3.0/3.1 control system, including: a USB control module including a USB3.0 control module and/or a USB3.1 control module; a PCS logic module connected to the USB control module via a PIPE interface; an FPGA Serdes serial communication module connected to the PCS logic module; and an external daughter card module connected to the FPGA Serdes serial communication module, wherein the PCS logic module, the FPGA Serdes serial communication module and the external daughter card module are connected in sequence to achieve a port physical layer function for testing the USB 3.0 control module and the USB 3.1 control module. The control system solves the cumbersome problems of incomplete emulation verification, test mode limitations, and unchangeable hardware functions in the prior art.

Abstract: A directed chemical conjugate of a glucagon-like peptide-2 mutant, and a use thereof are provided. The glucagon-like peptide-2 mutant is based on the human glucagon-like peptide-2 through multiple site mutations and carboxy terminus extensions. By introducing a targeted chemical modification site, the glucagon-like peptide-2 mutant has biological activities consistent with the natural human glucagon-like peptide-2, and meanwhile, the half-life period in vivo is significantly prolonged, and the administration frequency is reduced, thereby achieving the purpose of treating or preventing short intestinal syndrome, intestinal mucosa injury caused by chemotherapy medicaments or radioactive treatment factors, ulcerative enteritis, chronic enteritis and non-inflammatory bowel injury disease.

Abstract: An FPGA-based USB3.0/3.1 control system, including: a USB control module including a USB3.0 control module and/or a USB3.1 control module; a PCS logic module connected to the USB control module via a PIPE interface; an FPGA Serdes serial communication module connected to the PCS logic module; and an external daughter card module connected to the FPGA Serdes serial communication module, wherein the PCS logic module, the FPGA Serdes serial communication module and the external daughter card module are connected in sequence to achieve a port physical layer function for testing the USB 3.0 control module and the USB 3.1 control module. The control system solves the cumbersome problems of incomplete emulation verification, test mode limitations, and unchangeable hardware functions in the prior art.

Abstract: Methods and systems are provided for implementing quality estimation for automatic speech recognition, and more specifically training an ASR model, and training a QE model to perform word error rate prediction upon the trained ASR model. The ASR model may be a transformer learning model having an architecture including an encoder including multi-head attention layers, and a memory encoder including a masking multi-head attention layer. The QE model may include a binary classification model and a regression model, where the binary classification model is based on a discrete statistical distribution, and the regression model is based on a continuous statistical distribution. Training the ASR model may produce output having variable word error rates, and the QE model may be trained based on empirical word error rates of the ASR model. The QE model may predict performance of the ASR model without labor-intensive labeling to generate ground truth.

Abstract: Provided is a method for preparing a polyethylene glycol-modified urate oxidase, at least 11 of the following amino acid sites of the polyethylene glycol-modified urate oxidase have a PEG modification: T1, K3, K4, K30, K35, K76, K79, K97, K112, K116, K120, K152, K179, K222, K231, K266, K272, K285, K291, and K293, and the preparation method includes: performing a coupling reaction between urate oxidase and polyethylene glycol, wherein the polyethylene glycol is provided in the form of an acidic solution, and a molar ratio of the urate oxidase to the polyethylene glycol is 1: (56 to 94), to obtain the polyethylene glycol-modified urate oxidase.

Abstract: Provided is a urate oxidase preparation. The urate oxidase preparation includes polyethylene glycol-modified urate oxidase as an active ingredient and a buffer reagent as an excipient.

Abstract: A scramble and descramble hardware implementation method based on data bit width expansion. After expansion, redundant terms are eliminated, and scramble/descramble operation results within the current operation cycle and the value of the shift register after shifting are calculated at once. The present method exhibits advantageous effects with respect to the scramble and descramble polynomial defined by USB3.1 and PCI-Express3.0 protocols, and can obtain a relatively small hardware delay, so that the system can work at a higher frequency.

Abstract: A scramble and descramble hardware implementation method based on data bit width expansion. After expansion, redundant terms are eliminated, and scramble/descramble operation results within the current operation cycle and the value of the shift register after shifting are calculated at once. The present method exhibits advantageous effects with respect to the scramble and descramble polynomial defined by USB3.1 and PCI-Express3.0 protocols, and can obtain a relatively small hardware delay, so that the system can work at a higher frequency.

Abstract: Provided in the present disclosure is a fused protein. The fused protein comprises a plurality of target protein sequences, which are connected in series, wherein every two adjacent target protein sequences are connected by means of a linker sequence, the linker sequence is suitable for being cut into a plurality of free target proteins by means of protease, the multiple target protein sequences are not cleaved by the protease, and neither the C-terminus nor the N-terminus of the free target proteins contains additional residues.

Abstract: The present disclosure provides a polyethylene glycol-modified urate oxidase. At least 11 of the following amino acid sites in the urate oxidase have a PEG modification: T1, K3, K4, K30, K35, K76, K79, K97, K112, K116, K120, K152, K179, K222, K231, K266, K272, K285, K291, and K293.

Abstract: A clamping apparatus for coupling an ultrasonic transducer to a conduit is disclosed. The clamping apparatus comprises a base portion fastened to the conduit and including a bracket for receiving an adapter. The adapter is attached to a housing and allows the housing to be rotated when the adapter is positioned in an upper portion of the bracket, and prevents the housing from being rotated when the adapter is positioned in a lower portion of the bracket. The housing is configured to enclose the ultrasonic transducer except for a housing opening along the bottom of the housing. The ultrasonic transducer extends through the housing opening and is spring biased against the conduit.

Abstract: An automatic straightening device includes a fully-mechanized coal mining working face, which includes a plurality of middle troughs, and each middle trough is connected to a push-pull rod of one hydraulic support. The fully-mechanized coal mining working face is provided with the automatic straightening device. The automatic straightening device includes a flexible element rope, the tensile and compressive force sensors, and a signal processing device. Each middle trough is provided with two tensile and compressive force sensors; one end of the flexible element rope is connected to a rope extend-retract control device, and the other end of the flexible element rope sequentially passes through lifting rings to be connected to the tensile and compressive force sensors and is fixed to a positioning force bearing bolt on the outermost side.

Abstract: An automatic straightening device includes a fully-mechanized coal mining working face, which includes a plurality of middle troughs, and each middle trough is connected to a push-pull rod of one hydraulic support. The fully-mechanized coal mining working face is provided with the automatic straightening device. The automatic straightening device includes a flexible element rope, the tensile and compressive force sensors, and a signal processing device. Each middle trough is provided with two tensile and compressive force sensors; one end of the flexible element rope is connected to a rope extend-retract control device, and the other end of the flexible element rope sequentially passes through lifting rings to be connected to the tensile and compressive force sensors and is fixed to a positioning force bearing bolt on the outermost side.

Abstract: A clamping apparatus for coupling an ultrasonic transducer to a conduit is disclosed. The clamping apparatus comprises a base portion fastened to the conduit and including a bracket for receiving an adapter. The adapter is attached to a housing and allows the housing to be rotated when the adapter is positioned in an upper portion of the bracket, and prevents the housing from being rotated when the adapter is positioned in a lower portion of the bracket. The housing is configured to enclose the ultrasonic transducer except for a housing opening along the bottom of the housing. The ultrasonic transducer extends through the housing opening and is spring biased against the conduit.