Abstract: The present disclosure provides a method for preparing a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors, the composition prepared by the method, and use of the composition for treating arthritis. The composition of the present disclosure achieves the effect of treating arthritis through various efficacy experiments.

Abstract: The present disclosure provides a method for treating liver cirrhosis by using a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors. The composition of the present disclosure achieves the effect of treating liver cirrhosis through various efficacy experiments.

Abstract: A pen of the present invention includes a barrel having a space therein, a refill bore at a front end thereof and at least an opening at a circumference thereof. A refill, which is received in the barrel, has a tip extruded out of the barrel through the refill bore. A tube is received in a gap between the barrel and the refill for reciprocation. An elastic member is received in the barrel to urge the tube outwards so that the tip of the refill is received in the tube in a normal condition. A tube driving mechanism is received in the opening of the barrel and connected to the tube to move the tube inward the barrel for exposing the tip of the refill and compressing the elastic when the tube driving mechanism is pressed. The elastic member returns the tube when the tube driving mechanism is released.