Abstract: Conventional email filtering services are not suitable for recognizing sophisticated malicious emails, and therefore may allow sophisticated malicious emails to reach inboxes by mistake. Introduced here are threat detection platforms designed to take an integrative approach to detecting security threats. For example, after receiving input indicative of an approval from an individual to access past email received by employees of an enterprise, a threat detection platform can download past emails to build a machine learning (ML) model that understands the norms of communication with internal contacts (e.g., other employees) and/or external contacts (e.g., vendors). By applying the ML model to incoming email, the threat detection platform can identify security threats in real time in a targeted manner.

Abstract: A pharmaceutical product for administration of an anti HER2 antibody-drug conjugate in combination with an ATR inhibitor is provided. The anti-HER2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to an anti-HER2 antibody via a thioether bond.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer readable media for generating a recommended target audience based on determining a predicted attendance utilizing a neural network approach. For example, the disclosed systems can utilize an approximate nearest neighbor algorithm to identify individuals that are within a similarity threshold of invitees for an event. In addition, the disclosed systems can implement an attendance prediction model to determine a probability of an invitee attending the event. The disclosed systems can further determine a predicted attendance for an event based on the individual probabilities. Based on identifying the similar individuals to, and the attendance probabilities for, the invitees, the disclosed systems can generate a recommended target audience to satisfy a target attendance for an event based on a predicted attendance for the event.

Abstract: The invention relates to injectable pharmaceutical compositions, methods of use and formulation, wherein the compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co-solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the B criteria as it applies to parenterals, and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing, satisfying the criteria for Category 1 (injectable) products.

Abstract: A pharmaceutical product for administration of an anti HER2 antibody-drug conjugate in combination with an ATM inhibitor is provided. The anti-HER2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to an anti-HER2 antibody via a thioether bond. Also provided is a therapeutic use and method wherein the antibody-drug conjugate and the ATM inhibitor are administered in combination to a subject: Formula (I).

Abstract: The present disclosure relates to systems, methods, and non-transitory computer readable media for generating a recommended target audience based on determining a predicted attendance utilizing a neural network approach. For example, the disclosed systems can utilize an approximate nearest neighbor algorithm to identify individuals that are within a similarity threshold of invitees for an event. In addition, the disclosed systems can implement an attendance prediction model to determine a probability of an invitee attending the event. The disclosed systems can further determine a predicted attendance for an event based on the individual probabilities. Based on identifying the similar individuals to, and the attendance probabilities for, the invitees, the disclosed systems can generate a recommended target audience to satisfy a target attendance for an event based on a predicted attendance for the event.

Abstract: Injectable pharmaceutical compositions, methods of use and formulation are disclosed. The compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co-solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the B criteria as it applies to parenterals, and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing, satisfying the criteria for Category 1 (injectable) products.

Abstract: Injectable pharmaceutical compositions, methods of use and formulation are disclosed. The compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co-solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the B criteria as it applies to parenterals, and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing, satisfying the criteria for Category 1 (injectable) products.

Abstract: Injectable pharmaceutical compositions, methods of use and formulation are disclosed. The compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co-solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the B criteria as it applies to parenterals, and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing, satisfying the criteria for Category 1 (injectable) products.

Abstract: The invention relates to injectable pharmaceutical compositions, methods of use and formulation, wherein the compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co-solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the B criteria as it applies to parenterals, and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing, satisfying the criteria for Category 1 (injectable) products.

Abstract: The invention relates to injectable pharmaceutical compositions, methods of use and formulation, wherein the compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co-solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the B criteria as it applies to parenterals, and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing, satisfying the criteria for Category 1 (injectable) products.

Abstract: A system for the storage and retrieval of data files includes a data disk, a configuration disk and a controller. Each data file includes one or more data blocks, each data block comprising a data section. The data disk stores the data blocks and is divided into a plurality of block groups. The configuration disk stores a copy of at least a portion of the corresponding meta-data. The controller controls both the data disk and the configuration disk.

Abstract: A stable solvent-based composition is described which is particularly useful in warm blooded animals such as dogs. The composition comprises a therapeutically effective amount of carprofen, one or more polyols, one or more stabilising agents and optionally, one or more co-solvents.

Abstract: The application concerns a compound of formula I: wherein one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R3 group; Y is either O or S; R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; R3 is a phenyl or pyridyl group, attached by a first bridge group selected from —S—, —S(?O)—, —S(?O)2—, —O—, —NRN— and CRC1RC2— to an optionally substituted C5-20 carboaryl group, the phenyl or pyridyl group and optionally substituted C5-20 carboaryl group being optionally further linked by a second bridge group, so as to form an optionally substituted C5-7 ring, the phenyl or pyridyl group being further optionally substituted.

Abstract: A system and method for exporting a virtual tape from a virtual tape library. The system preferably presents a user with a user interface styled for manipulating a physical tape library. The virtual tape library performs the data storage and retrieval functions. The system includes the user interface having a plurality of user selectable fields styled to interface with the physical tape library. A data storage medium has at least one virtual library and/or virtual tape defined thereon. The data storage medium is capable of storing a plurality of data in the at least one virtual library and/or virtual tape. A physical data storage device is detachably able to be put in communication with the at least one virtual library and/or virtual tape to receive at least a portion of the plurality of data therefrom.

Abstract: A method of importing a plurality of data from a physical data storage device into a virtual tape library system that is used with a data protection application. The virtual tape library system is usable with an existing data protection application designed for use with a physical tape library without modifying the existing data protection application. The method includes: triggering a signal representing a command to import the plurality of data from the physical data storage device; providing a controller that receives the signal; providing a data storage medium in communication with the controller, the data storage medium has at least one virtual library defined thereon; and copying at least a portion of the plurality of data from the physical data storage device to a virtual tape.

Abstract: A method of importing a plurality of data from a physical data storage device into a virtual tape library system that is used with a data protection application. The virtual tape library system is usable with an existing data protection application designed for use with a physical tape library without modifying the existing data protection application. The method includes: triggering a signal representing a command to import the plurality of data from the physical data storage device; providing a controller that receives the signal; providing a data storage medium in communication with the controller, the data storage medium has at least one virtual library defined thereon; and copying at least a portion of the plurality of data from the physical data storage device to a virtual tape.

Abstract: A system and method for exporting a virtual tape from a virtual tape library. The system preferably presents a user with a user interface styled for manipulating a physical tape library. The virtual tape library performs the data storage and retrieval functions. The system includes the user interface having a plurality of user selectable fields styled to interface with the physical tape library. A data storage medium has at least one virtual library and/or virtual tape defined thereon. The data storage medium is capable of storing a plurality of data in the at least one virtual library and/or virtual tape. A physical data storage device is detachably able to be put in communication with the at least one virtual library and/or virtual tape to receive at least a portion of the plurality of data therefrom.

Abstract: A system for the storage and retrieval of data files includes a data disk, a configuration disk and a controller. Each data file includes one or more data blocks, each data block comprising a data section. The data disk stores the data blocks and is divided into a plurality of block groups. The configuration disk stores a copy of at least a portion of the corresponding meta-data. The controller controls both the data disk and the configuration disk.

Abstract: The application concerns a compound of formula I: 1