Abstract: Double-stranded ribonucleic acids (dsRNA) of at least 45 bp, preferably of at least 50 bp, which dsRNA include at least one 5?-triphosphate group and further includes at least one chemical modification at a 5? end, at a 3? end and/or at a non-terminal nucleotide. The invention further provides pharmaceutical compositions containing such modified dsRNAs, methods for their production, and to their use in medicine, in particular for immunostimulation and treatment as well as prevention of infectious, autoimmune, degenerative, cancer and tumor diseases.

Abstract: Double-stranded ribonucleic acids (dsRNA) of at least 45 bp, preferably of at least 50 bp, which dsRNA include at least one 5?-triphosphate group and further includes at least one chemical modification at a 5? end, at a 3? end and/or at a non-terminal nucleotide. The invention further provides pharmaceutical compositions containing such modified dsRNAs, methods for their production, and to their use in medicine, in particular for immunostimulation and treatment as well as prevention of infectious, autoimmune, degenerative, cancer and tumor diseases.

Abstract: The present invention relates to the qualitative and/or quantitative determination of a proteinaceous molecule in a plurality of samples by combining a particular labeling and fractionation strategy. In particular, each sample is provided with a dye chosen from a set of dyes, wherein each dye within the set of dyes emits luminescent light at a wavelength that is sufficiently different from the emitted luminescent light of the remaining dyes in the set of dyes to provide a different light signal when excited. Subsequent to labelling the proteinaceous molecule with the fluorescent dye, the samples are combined and fractionated by means of electrophoresis, the labeled proteinaceous molecule having a relative electrophoretic mobility that differs from the electrophoretic mobility of the proteinaceous molecule labeled with another dye within the set of dyes. After capturing separate images of the labeled proteinaceous molecule at different wavelengths, the images are aligned by means of image processing.