Abstract: This disclosure is directed to a process for producing a pharmaceutical composition for treating or preventing a disease. The pharmaceutical composition can comprise a polymer-drug nanoaggregate having a polymer and at least one bioactive agent that is water insoluble or poorly water soluble. The polymer is water soluble and comprises at least one first terminal group modified with H (H) or a hydrophobic moiety (C) and a second terminal group modified with a hydrophilic moiety. The polymer can be a modified symmetrically or asymmetrically branched polymers. This disclosure is further directed to a method for producing a polymer having a pre-defined H/C ratio.

Abstract: This disclosure is directed to a pharmaceutical composition for treating or preventing a disease. The pharmaceutical composition can comprise a targeting bioactive agent (TBA); a payload bioactive agent (PBA) covalently linked to the targeting bioactive agent (TBA) directly or indirectly; and, optionally, a polymer forming nanoaggregates. The pharmaceutical composition can comprise Ag+ tumor cytotoxicity to tumor cells having a tumor antigen (Ag+ tumor cells) and Ag? tumor cytotoxicity to tumor cells free from a tumor antigen (Ag? tumor cells). The pharmaceutical composition can be an antibody-drug conjugate (ADC) for treating cancers having tumor antigen positive (Ag+) tumor cells, tumor antigen negative (Ag?) tumor cells, or heterogenous cancers having both tumor antigen positive (Ag+) tumor cells and tumor antigen negative (Ag?) tumor cells.

Abstract: A constant temperature system is provided, including: a HVAC system; a first thermostat configured to control the HVAC system; a second thermostat for replacing the first thermostat; an application in a terminal device for guiding installation of the second thermostat. The terminal device includes a display screen. The application is configured to: obtain a first wiring connection mode, determine a system configuration of the HVAC system, determine a type of an energy source for driving the HVAC system to operate, obtain a second wiring connection mode according to the first wiring connection mode, instruct a user to replace the thermostat according to the second wiring connection mode; obtain control logic matching the system configuration and the type of the energy source to enable the second thermostat to control the HVAC system when the second thermostat and the HVAC system are connected in the second wiring connection mode.

Abstract: This disclosure is directed to a pharmaceutical composition for treating or preventing a disease. The pharmaceutical composition can comprise a polymer-drug nanoaggregate having a polymer and at least one bioactive agent that is water insoluble or poorly water soluble. The polymer is water soluble and comprises at least one first terminal group modified with H or a hydrophobic moiety and a second terminal group modified with a hydrophilic moiety and can be a modified symmetrically or asymmetrically branched polymers. This disclosure is also directed to a method for treating or preventing a disease including one or more immune disorders, infectious diseases and cancers using the pharmaceutical composition disclosed herein. The pharmaceutical composition can be a vaccine or an adjuvant for a vaccine.

Abstract: This disclosure is directed to a pharmaceutical composition for treating or preventing a disease. The pharmaceutical composition can comprise a polymer-drug nanoaggregate having a polymer and at least one bioactive agent that can comprise STING polypeptide, a nucleic acid encoding said STING polypeptide, a STING inhibitor, a STING activator, a STING agonist, a STING antagonist, a STING modulating molecule, or a combination thereof. The pharmaceutical composition can be a vaccine or an adjuvant for a vaccine. This disclosure is also directed to a method for treating or preventing a disease using the pharmaceutical composition. The disease can include infectious diseases caused by viruses or other pathogens, for example, influenza, rabies, or respiratory illnesses such as severe acute respiratory syndrome (SARS) caused by coronaviruses, such as MERS-CoV, SARS-CoV, and Coronavirus Disease 2019 (COVID-19) caused by the virus SARS-CoV-2 and its variants.

Abstract: A cutting tool includes a housing, a battery pack coupling portion, an electric motor, a control board, a control unit, and a display assembly. The battery pack coupling portion is configured to be connected to a battery pack for powering the cutting tool. The electric motor can drive a working accessory to rotate and is electrically connected to the control board. The cutting tool further includes a display mechanism. The display mechanism includes the control unit and the display assembly. The control unit is electrically connected to the control board. The display assembly is electrically connected to the control unit. When the control unit transmits an electrical signal to the display assembly, the display assembly displays a rotation direction of the electric motor or other information.

Abstract: A constant temperature system is provided, including: a HVAC system; a first thermostat configured to control the HVAC system; a second thermostat for replacing the first thermostat; an application in a terminal device for guiding installation of the second thermostat. The terminal device includes a display screen. The application is configured to: obtain a first wiring connection mode, determine a system configuration of the HVAC system, determine a type of an energy source for driving the HVAC system to operate, obtain a second wiring connection mode according to the first wiring connection mode, instruct a user to replace the thermostat according to the second wiring connection mode; obtain control logic matching the system configuration and the type of the energy source to enable the second thermostat to control the HVAC system when the second thermostat and the HVAC system are connected in the second wiring connection mode.

Abstract: The embodiment of the present application discloses a Bluetooth communication method, comprising: detecting a posture of a mobile terminal; establishing a Bluetooth connection with a desired Bluetooth device when a first posture is detected; and/or disconnecting the Bluetooth connection when a second posture is detected, wherein the second posture is different from the first posture.

Abstract: The disclosure generally relates to filaments and in particular, filaments for use in fused filament fabrication to prepare 3D printed articles. The filaments may be prepared from a polymer composition comprising: A) 55 to 95 weight percent semi-aromatic copolyamide having a melting point; and B) 5 to 45 weight percent amorphous copolyamide having a melting point.

Abstract: A method of data transmission includes: receiving a first packet, where the first packet includes first compressed data and a first check value, the first compressed data is obtained by compressing first data based on a first compression mode, the first check value is obtained by processing a second check value based on a first check algorithm, the second check value is obtained by processing the first compressed data based on a second check algorithm; obtaining a first check code by processing the first packet based on a third check algorithm; determining, according to a correspondence between the first check code and the first compression mode, that the first compression mode is a compression mode used when the first data is compressed; and obtaining the first data by decompressing, based on a first decompression mode corresponding to the first compression mode, the first compressed data included in the first packet.

Abstract: An experimental system for studying a refining mechanism and characteristic of a refiner plate, including a disc refiner unit, a first storage tank, a second storage tank, a circulating pump, a pipeline system, a detection device for measuring process variables including flow, pressure and temperature, and a data acquisition and control system. An operation parameter control system is provided to control an operation state of valves at different positions of the pipeline system to achieve the switching of the operation mode of the experimental system. The data acquisition and control system is configured to collect the parameters at different detection points. A method for operating the experimental system is also provided.

Abstract: A cone shaped pin (16) for tower wall attachment is disclosed. The pin comprises a cone (22) with a first head (23) and a second head (24), the first head is larger than the second head. The pin further comprises an internal hole (18a) which is at least accessible from the second head. A system (15) for tower wall attachment and a method for mounting the system are also disclosed. In the case of using the system comprising the pin, tower wall attachment is better and safer than that in the art, and welding is avoid, thus greatly simplifies the process of fixing and improves the performance of the tower.

Abstract: Disclosed are additive manufacturing compositions comprising: A) 100 to 30 weight percent of a polyamide composition comprising: a) 95 to 5 weight percent of at least one semi-crystalline copolyamide having a melting point, said semi-crystalline copolyamide comprising: i) 5 to 40 mole percent aromatic repeat units derived from one or more aromatic dicarboxylic acids with 8 to 20 carbon atoms and at least one aliphatic diamine with 4 to 20 carbon atoms; and ii) 60 to 95 mole percent aliphatic repeat units derived from one or more aliphatic dicarboxylic acids with 6 to 20 carbon atoms and one or more aliphatic diamines with 4 to 20 carbon atoms; b) 5 to 95 weight percent of at least one amorphous copolyamide comprising: iii) 60 to 90 mole percent aromatic repeat units derived from isophthalic acid and at least one aliphatic diamine with 4 to 20 carbon atoms; and iv) 10 to 40 mole percent aromatic repeat units derived from terephthalic acid and at least one aliphatic diamine with 4 to 20 carbon atoms; and B) 0 t

Abstract: This invention is directed to a biodegradable polymer that can be degraded in vivo. The biodegradable polymer comprises a biodegradable polymer segment having at least a biodegradable bond and two or more cationic components, wherein each of said cationic components is covalently attached to the biodegradable polymer segment and the two cationic components/molecules are separated by at least one biodegradable bond in the backbone. The biodegradable polymer can be used for targeting desired ceils in vivo including T cells, NK (natural killer) ceils, cancer cells, or a combination thereof, delivering genes, DNA, oligodeoxynucleotide, oligonucleotide, RNA, mRNA, RNAi, siRNA, microRNA, protein, peptide, antibody, fragment of an antibody, small molecule drug including chemotherapy drugs, or other bioactive agents into cells, or being used as a vaccine or drug for treating a disease such as a cancer in a subject.

Abstract: The disclosure generally relates to filaments and in particular, filaments for use in fused filament fabrication to prepare 3D printed articles. The filaments may be prepared from a polymer composition comprising: A) 55 to 95 weight percent semi-aromatic copolyamide having a melting point; and B) 5 to 45 weight percent amorphous copolyamide having a melting point.

Abstract: The present invention comprises a composition and method of use for providing durable dirt pickup resistance to architectural coatings. Such compositions comprise a coating base and a post-modified crosslinkable fluoropolymer additive, such that the coatings additive is allowed to migrate to the coating surface and further cure once applied to a substrate. The compositions of the present invention provide durability to coating compositions, while also providing surface effects such as increased water and oil contact angles, enhanced dirt pickup resistance, and enhanced cleanability to the coating films.

Abstract: A method and apparatus for system call command batch processing are provided. The method enable system call commands of a same type to be processed in a same CPU core according to a sequence of entering a kernel, thereby ensuring that returned results of the system call commands are sequential.