Patents by Inventor Kai-Shu Ling
Kai-Shu Ling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7211710Abstract: In general, the invention features a method for selecting a transgenic grapevine or grapevine component having increased resistance to a grapevine fanleaf disease. The method involves (a) transforming a grape plant cell with a grapevine fanleaf virus coat protein nucleic acid molecule or fragment thereof which is expressed in the plant cell; (b) regenerating a transgenic grapevine or grapevine component from the plant cell; and (c) selecting a transgenic grapevine or grapevine component expressing a grapevine fanleaf virus coat protein or coat protein fragment thereof, where the coat protein or the coat protein fragment thereof is expressed at a level equal to or less than an optical density of about 0.2 at 405 nm as detected by an enzyme-linked immunoassay as compared to a control plant, the selected transgenic grapevine or grapevine component having resistance to the grapevine fanleaf disease.Type: GrantFiled: February 28, 2003Date of Patent: May 1, 2007Assignee: Cornell Research Foundation, Inc.Inventors: Dennis Gonsalves, Baodi Xue, Tania Krastanova, Kai-Shu Ling, Marc Fuchs
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Publication number: 20050183165Abstract: The present invention relates to isolated proteins or polypeptides of grapevine leafroll virus (type 2). The encoding DNA molecules either alone in isolated form or in an expression system, a host cell, or a transgenic grape plant are also disclosed. Other aspects of the present invention relates to a method of imparting grapevine leafroll resistance to grape and tobacco plants by transforming them with the DNA molecules of the present invention, a method of imparting beet yellows virus resistance to a beet plant, a method of imparting tristeza virus resistance to a citrus plant, and a method of detecting the presence of a grapevine leafroll virus, such as GRLaV-2, in a sample.Type: ApplicationFiled: December 9, 2004Publication date: August 18, 2005Applicant: Cornell Research Foundation, Inc.Inventors: Hai-Ying Zhu, Kai-Shu Ling, Dennis Gonsalves
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Publication number: 20050160492Abstract: The present invention relates to an isolated GLRaV-3 protein or polypeptide selected from a group of a polyprotein, a proteinase, a methyltransferase, a helicase, and an RNA-dependent RNA polymerase. The encoding DNA molecule either alone in isolated form or in an expression system, a host cell, or a transgenic grape plant is also disclosed. Another aspect of the present invention relates to a method of imparting grapevine leafroll resistance to grape plants by transforming them with the DNA molecule of the present invention.Type: ApplicationFiled: December 13, 2004Publication date: July 21, 2005Applicant: Cornell Research FoundationInventors: Dennis Gonsalves, Kai-Shu Ling
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Patent number: 6916617Abstract: The invention features a method of detecting the presence of a grapevine leafroll virus in a sample using immunological or nucleic-acid based methodologies.Type: GrantFiled: December 31, 2001Date of Patent: July 12, 2005Assignee: Cornell Research Foundation, Inc.Inventors: Dennis Gonsalves, Kai-Shu Ling
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Publication number: 20050058989Abstract: The invention features antibodies, binding portions thereof, and probes which recognize grapevine leafroll virus proteins and polypeptides.Type: ApplicationFiled: January 21, 2004Publication date: March 17, 2005Inventors: Dennis Gonsalves, Kai-Shu Ling
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Patent number: 6858426Abstract: The present invention relates to isolated proteins or polypeptides of grapevine leafroll virus (type 2). The encoding DNA molecules either alone in isolated form or in an expression system, a host cell, or a transgenic grape plant are also disclosed. Other aspects of the present invention relates to a method of imparting grapevine leafroll resistance, to grape and tobacco plants by transforming them with the DNA molecules of the present invention, a method of imparting beet yellows virus resistance to a beet plant, a method of imparting tristeza virus resistance to a citrus plant, and a method of detecting the presence of a grapevine leafroll virus, such as GRLaV-2, in a sample.Type: GrantFiled: July 11, 2000Date of Patent: February 22, 2005Assignee: Cornell Research Foundation, Inc.Inventors: Hai-Ying Zhu, Kai-Shu Ling, Dennis Gonsalves
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Patent number: 6667426Abstract: In general, the invention features a method for selecting a transgenic grapevine or grapevine component having increased resistance to a fanleaf disease, the method including the steps of: (a) transforming a grape plant cell with a grape nepovirus coat protein nucleic acid molecule or fragment thereof which is capable of being expressed in the plant cell; (b) regenerating a transgenic grapevine or grapevine component from the plant cell; and (c) selecting a transgenic grapevine or grapevine component which expresses, at a low level, the nucleic acid molecule or fragment thereof, wherein the low level expression increases the resistance of the transgenic grapevine or grapevine component to fanleaf disease. The invention also relates to an isolated nucleic acid molecule encoding a coat protein or fragment thereof of a ‘Geneva’ isolate of a grapevine nepovirus virus.Type: GrantFiled: September 28, 1998Date of Patent: December 23, 2003Assignee: Cornell Research Foundation, Inc.Inventors: Dennis Gonsalves, Baodi Xue, Tania Krastanova, Kai-Shu Ling, Marc Fuchs
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Publication number: 20030226172Abstract: In general, the invention features a method for selecting a transgenic grapevine or grapevine component having increased resistance to a grapevine fanleaf disease. The method involves (a) transforming a grape plant cell with a grapevine fanleaf virus coat protein nucleic acid molecule or fragment thereof which is expressed in the plant cell; (b) regenerating a transgenic grapevine or grapevine component from the plant cell; and (c) selecting a transgenic grapevine or grapevine component expressing a grapevine fanleaf virus coat protein or coat protein fragment thereof, where the coat protein or the coat protein fragment thereof is expressed at a level equal to or less than an optical density of about 0.2 at 405 nm as detected by an enzyme-linked immunoassay as compared to a control plant, the selected transgenic grapevine or grapevine component having resistance to the grapevine fanleaf disease.Type: ApplicationFiled: February 28, 2003Publication date: December 4, 2003Inventors: Dennis Gonsalves, Baodi Xue, Tania Krastanova, Kai-Shu Ling, Marc Fuchs
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Patent number: 6638720Abstract: The present invention relates to an isolated protein or polypeptide corresponding to a coat protein or polypeptide of a grapevine leafroll virus. The encoding DNA molecule either alone in isolated form or in an expression system, a host cell, or a transgenic grape plant is also disclosed. Another aspect of the present invention relates to a method of imparting grapevine leafroll resistance to grape plants by transforming them with the DNA molecule of the present invention. A method for imparting tristeza virus resistance in citrus plants using the DNA molecule of the present invention is also disclosed.Type: GrantFiled: August 29, 2000Date of Patent: October 28, 2003Assignee: Cornell Research Foundation, Inc.Inventors: Dennis Gonsalves, Kai-Shu Ling
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Publication number: 20030198942Abstract: The invention features a method of detecting the presence of a grapevine leafroll virus in a sample using immunological or nucleic-acid based methodologies.Type: ApplicationFiled: December 31, 2001Publication date: October 23, 2003Inventors: Dennis Gonsalves, Kai-Shu Ling
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Patent number: 6558953Abstract: The present invention relates to an isolated protein or polypeptide corresponding to a coat protein or polypeptide of a grapevine leafroll virus. The encoding DNA molecule either alone in isolated form or in an expression system, a host cell, or a transgenic grape plant is also disclosed. Another aspect of the present invention relates to a method of imparting grapevine leafroll resistance to grape plants by transforming them with the DNA molecule of the present invention. A method for imparting tristeza virus resistance in citrus plants using the DNA molecule of the present invention is also disclosed.Type: GrantFiled: May 25, 2000Date of Patent: May 6, 2003Assignee: Cornell Research Foundation, Inc.Inventors: Dennis Gonsalves, Kai-Shu Ling
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Patent number: 6197948Abstract: The present invention relates to isolated proteins or polypeptides of grapevine leafroll virus (type 2). The encoding DNA molecules either alone in isolated form or in an expression system, a host cell, or a transgenic grape plant are also disclosed. Other aspects of the present invention relates to a method of imparting grapevine leafroll resistance to grape and tobacco plants by transforming them with the DNA molecules of the present invention, a method of imparting beet yellows virus resistance to a beet plant, a method of imparting tristeza virus resistance to a citrus plant, and a method of detecting the presence of a grapevine leafroll virus, such as GRLaV-2, in a sample.Type: GrantFiled: May 19, 1998Date of Patent: March 6, 2001Assignee: Cornell Research Foundation, Inc.Inventors: Hai-Ying Zhu, Kai-Shu Ling, Dennis Gonsalves
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Patent number: 5907085Abstract: The present invention relates to an isolated protein or polypeptide corresponding to a coat protein or polypeptide of a grapevine leafroll virus. The encoding DNA molecule either alone in isolated form or in an expression system, a host cell, or a transgenic grape plant is also disclosed. Another aspect of the present invention relates to a method of imparting grapevine leafroll resistance to grape plants by transforming them with the DNA molecule of the present invention. A method for imparting tristeza virus resistance in citrus plants using the DNA molecule of the present invention is also disclosed.Type: GrantFiled: December 20, 1996Date of Patent: May 25, 1999Assignee: Cornell Research Foundation, Inc.Inventors: Dennis Gonsalves, Kai-Shu Ling