Patents by Inventor Kai-Uwe Baldenius
Kai-Uwe Baldenius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220259580Abstract: The present disclosure relates to methods for producing human milk oligosaccharide (HMO) core structures using glycosidases from family GH20 hexosaminidases. In particular, the present disclosure provides methods for producing lacto-N-triose II (LNT II) and/or lacto-N-tetraose (LNT) by reacting glucosamine-oxazoline and/or lacto-N-biose-oxazoline with lactose catalysed by an enzyme of the glycoside hydrolase family 20 (GH20) according to the classification of the Carbohydrate-Active-Enzymes (CAZy) database. Specific optimized enzymes are identified to catalyse the reactions.Type: ApplicationFiled: December 9, 2019Publication date: August 18, 2022Inventors: Kai-Uwe Baldenius, Michael Breuer, Corinna Ruffer, Melanie Weingarten, Reinhard Zschoche, Stefan Seemayer, Bernd Nidetzky, Katharina Schmoelzer, Michael Puhl
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Publication number: 20220017931Abstract: Described herein are methods for the production of 4-cyano benzoic acid or salts thereof from terephthalonitrile using nitrilase as catalyst. Also described herein are compositions including 4-cyano benzoic acid.Type: ApplicationFiled: January 20, 2020Publication date: January 20, 2022Inventors: Diego Ghislieri, Christian Willrodt, Christopher Koradin, Stefan Seemayer, Doreen Schachtschabel, Kai-Uwe Baldenius, Roland Goetz
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Patent number: 10655152Abstract: The present invention relates to means and methods for producing an amide compound from a nitrile compound with less acrylic acid as by-product using a Nitrile hydratase (NHase) and Amidase producing microorganism as biocatalyst. Also provided is an aqueous amide compound obtained by the methods of the invention as well as a composition comprising acrylamide or polyacrylamide as well as a dried microorganism exhibiting a NHase/Amidase activity ratio of at least 400 when being brought into contact with a nitrile compound to convert said nitrile compound into an amide compound.Type: GrantFiled: September 30, 2015Date of Patent: May 19, 2020Assignee: SOLENIS TECHNOLOGIES, L.P.Inventors: Michael Budde, Michael Braun, Juergen Daeuwel, Peter Oedman, Kai-Uwe Baldenius, Matthias Kleiner, Stephan Freyer
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Patent number: 10533201Abstract: The present invention relates to methods of producing sugar phosphates by enzymatic transphosphorylation, wherein the phosphoryl transfer from phosphate donor substrates to sugar substrates is catalyzed by an enzyme having alpha-glucose-1-phosphatase activity. Furthermore, the present invention relates to a biocatalyst having sucrose phosphorylase as well as alpha-glucose-1-phosphatase activity and its use. The production of an enzyme having alpha-glucose-1-phosphatase activity and its use in the transphosphorylation of sugar substrates is also presented herein.Type: GrantFiled: June 30, 2015Date of Patent: January 14, 2020Assignee: BASF SEInventors: Vaidotas Navickas, Kai-Uwe Baldenius, Michael Breuer, Patricia Wildberger, Martin Pfeiffer, Bernd Nidetzky
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Patent number: 10428361Abstract: The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.Type: GrantFiled: February 19, 2016Date of Patent: October 1, 2019Assignee: BASF SEInventors: Vaidotas Navickas, Michael Breuer, Michael Puhl, Melanie Weingarten, Kai-Uwe Baldenius, Wolfgang Siegel
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Patent number: 10227621Abstract: The present invention relates to methods for preparing an aqueous acrylamide solution having a low acrylic acid concentration. In addition, the present invention relates to methods for reducing the acrylic acid concentration of an aqueous acrylamide solution. The methods involve a bioconversion of acrylonitrile to acrylamide in the presence of a biocatalyst, wherein during the bioconversion the content of acrylonitrile is maintained at 0.3 w/w % or more referred to the total weight of the composition in the reactor. Also provided is an aqueous acrylamide solution which is obtained by the methods of the present invention. Furthermore, the present invention is related to an acrylamide homopolymer or copolymer obtained by polymerizing the acrylamide of the aqueous solution.Type: GrantFiled: September 30, 2015Date of Patent: March 12, 2019Assignee: BASF SEInventors: Michael Guenter Braun, Juergen Daeuwel, Hans-Juergen Lang, Peter Oedman, Kai-Uwe Baldenius, Matthias Kleiner, Michael Kiefer, Stephan Freyer, Michael Budde
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Publication number: 20180148753Abstract: The present invention relates to methods of producing sugar phosphates by enzymatic transphosphorylation, wherein the phosphoryl transfer from phosphate donor substrates to sugar substrates is catalyzed by an enzyme having alpha-glucose-1-phosphatase activity. Furthermore, the present invention relates to a biocatalyst having sucrose phosphorylase as well as alpha-glucose-1-phosphatase activity and its use. The production of an enzyme having alpha-glucose-1-phosphatase activity and its use in the transphosphorylation of sugar substrates is also presented herein.Type: ApplicationFiled: June 30, 2015Publication date: May 31, 2018Inventors: Vaidotas NAVICKAS, Kai-Uwe BALDENIUS, Michael BREUER, Patricia WILDBERGER, Martin PFEIFFER, Bernd NIDETZKY
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Publication number: 20180073047Abstract: The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.Type: ApplicationFiled: February 19, 2016Publication date: March 15, 2018Inventors: Vaidotas NAVICKAS, Michael BREUER, Michael PUHL, Melanie WEINGARTEN, Kai-Uwe BALDENIUS, Wofgang SIEGEL
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Patent number: 9834798Abstract: A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.Type: GrantFiled: September 3, 2013Date of Patent: December 5, 2017Assignee: BASF SEInventors: Andrea Piatesi, Kai-Uwe Baldenius, Klaus Ditrich, Alois Kindler, Marta Zajaczkowski-Fischer, Ralf Boehling, Alwin Rehfinger
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Publication number: 20170283840Abstract: The present invention relates to methods for preparing an aqueous acrylamide solution having a low acrylic acid concentration. In addition, the present invention relates to methods for reducing the acrylic acid concentration of an aqueous acrylamide solution. The methods involve a bioconversion of acrylonitrile to acrylamide in the presence of a biocatalyst, wherein during the bioconversion the content of acrylonitrile is maintained at 0.3 w/w % or more referred to the total weight of the composition in the reactor. Also provided is an aqueous acrylamide solution which is obtained by the methods of the present invention. Furthermore, the present invention is related to an acrylamide homopolymer or copolymer obtained by polymerizing the acrylamide of the aqueous solution.Type: ApplicationFiled: September 30, 2015Publication date: October 5, 2017Applicant: BASF SEInventors: Michael BRAUN, Juergen DAEUWEL, Hans-Juergen LANG, Peter OEDMAN, Kai-Uwe BALDENIUS, Matthias KLEINER, Michael KIEFER, Stephan FREYER, Michael BUDDE
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Publication number: 20170260519Abstract: The present invention relates to methods for cultivating a nitrile hydratase producing microorganism, compositions for cultivating a nitrile hydratase producing microorganism, and use of compositions comprising a saccharide and an organic acid for cultivating a nitrile hydratase producing microorganism. The composition provided in and to be employed in context with the present invention is particularly suitable for inducing both, growth and nitrile hydratase production of corresponding microorganisms.Type: ApplicationFiled: September 30, 2015Publication date: September 14, 2017Applicant: BASF SEInventors: Kerstin HAGE, Carsten SCHWALB, Petra SPROETE, Peter OEDMAN, Kai-Uwe BALDENIUS, Burkhard ERNST, Gunter STEIGELMANN, Stephan FREYER, Claus BOLLSCHWEILER, Michael Guenter BRAUN, Juergen DAEUWEL
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Publication number: 20170247726Abstract: The present invention relates to means and methods for producing an amide compound from a nitrile compound with less acrylic acid as by-product using a Nitrile hydratase (NHase) and Amidase producing microorganism as biocatalyst. Also provided is an aqueous amide compound obtained by the methods of the invention as well as a composition comprising acrylamide or polyacrylamide as well as a dried microorganism exhibiting a NHase/Amidase activity ratio of at least 400 when being brought into contact with a nitrile compound to convert said nitrile compound into an amide compound.Type: ApplicationFiled: September 30, 2015Publication date: August 31, 2017Applicant: BASF SEInventors: Michael BUDDE, Michael BRAUN, Juergen DAEUWEL, Peter OEDMAN, Kai-Uwe BALDENIUS, Matthias KLEINER, Stephan FREYER
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Publication number: 20170145451Abstract: The present invention relates to a novel biocatalytic method for the production of primary and secondary amines, comprising coupled enzymatic oxidation and reduction processes simultaneously regenerating the required cofactor; making use of two enzymes—i.e. an alcohol dehydrogenase and an amine dehydrogenase—operating simultaneously in a one pot process (i.e. biocatalytic cascade). Furthermore, the overall process is redox neutral, since the hydride generated from the first oxidative step is internally recycled in the second reductive step. The invention also relates to recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods.Type: ApplicationFiled: July 2, 2015Publication date: May 25, 2017Inventors: Kai-Uwe Baldenius, Michael Breuer, Klaus Ditrich, Vaidotas Navickas, Francesco Mutti, Tanja Knaus, Nicholas Turner
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Publication number: 20150259713Abstract: A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.Type: ApplicationFiled: September 3, 2013Publication date: September 17, 2015Applicant: BASF SEInventors: Andrea Piatesi, Kai-Uwe Baldenius, Klaus Ditrich, Alois Kindler, Marta Zajaczkowski-Fischer, Ralf Boehling, Alwin Rehfinger
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Patent number: 9109200Abstract: The invention relates to the use of an enzyme preparation which catalyzes the degradation of formaldehyde for reducing the formaldehyde content in a formaldehyde-containing formulation. In a preferred embodiment, the enzyme preparation contains a formaldehyde dismutase from a Pseudomonas putida strain. Further, the invention refers to a process for reducing the formaldehyde content in cross-linking agents for textile finishing or in polymer dispersions used, e.g. in construction chemistry. Further the invention relates to the use of an enzyme preparation which catalyzes the degradation of aldehydes for reducing the formaldehyde content in an aldehyde-containing formulation. Furthermore, the invention relates to a novel variant of the formaldehyde dismutase from Pseudomonas putida.Type: GrantFiled: March 31, 2010Date of Patent: August 18, 2015Assignee: BASF SEInventors: Andrea Piatesi, Tilo Habicher, Michael Büschel, Li-Wen Wang, Jürgen Reichert, Rainer Packe-Wirth, Kai-Uwe Baldenius, Erich Kromm, Stefan Häfner, Carsten Schwalb, Hans Wolfgang Höffken
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Patent number: 9080191Abstract: The present invention relates to novel methods for biocatalytic production of nitriles from oximes using oxime dehydratases and novel mutants with oxime dehydratase activity and use thereof in a process for biocatalytic production of nitriles, such as in particular for the production of citral nitrile, neral nitrile, geranial nitrile or citronellyl nitrile from citral oxime, neral oxime, geranial oxime or citronellal oxime; and oxime dehydratases usable therefor, nucleotide sequences therefor and expression constructs or microorganisms comprising these.Type: GrantFiled: March 13, 2013Date of Patent: July 14, 2015Assignee: BASF SEInventors: Andrea Piatesi, Wolfgang Siegel, Kai-Uwe Baldenius
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Publication number: 20130244298Abstract: The present invention relates to novel methods for biocatalytic production of nitriles from oximes using oxime dehydratases and novel mutants with oxime dehydratase activity and use thereof in a process for biocatalytic production of nitriles, such as in particular for the production of citral nitrile, neral nitrile, geranial nitrile or citronellyl nitrile from citral oxime, neral oxime, geranial oxime or citronellal oxime; and oxime dehydratases usable therefor, nucleotide sequences therefor and expression constructs or microorganisms comprising these.Type: ApplicationFiled: March 13, 2013Publication date: September 19, 2013Inventors: Andrea Piatesi, Wolfgang Siegel, Kai-Uwe Baldenius
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Publication number: 20130197275Abstract: The present invention relates to new types of specifically alkoxylated farnesol alkoxylates based on farnesol or at least partially hydrogenated farnesol, directly linked to a propylene oxide block; processes for the preparation of these alkoxylates and the use thereof in washing, rinsing, cleaning or finishing compositions, cosmetic compositions, compositions for papermaking, agrochemical compositions, fuel additives and solubilization auxiliaries in aqueous liquid systems.Type: ApplicationFiled: January 31, 2013Publication date: August 1, 2013Inventors: WOLFGANG SPIEGLER, KAI-UWE BALDENIUS, MICHAEL TRILLER, JUERGEN TROPSCH
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Publication number: 20130197276Abstract: The present invention relates to new types of farnesol alkoxylates, based on at least partially hydrogenated farnesol; processes for the preparation of these alkoxylates and the use thereof in washing, rinsing, cleaning or finishing compositions, cosmetic compositions, compositions for papermaking, fuel additives and solubilization auxiliaries in aqueous liquid systems.Type: ApplicationFiled: January 31, 2013Publication date: August 1, 2013Inventors: Wolfgang SPIEGLER, Kai-Uwe Baldenius, Michael Triller, Juergen Tropsch
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Publication number: 20120028333Abstract: The invention relates to the use of an enzyme preparation which catalyzes the degradation of formaldehyde for reducing the formaldehyde content in a formaldehyde-containing formulation. In a preferred embodiment, the enzyme preparation contains a formaldehyde dismutase from a Pseudomonas putida strain. Further, the invention refers to a process for reducing the formaldehyde content in cross-linking agents for textile finishing or in polymer dispersions used, e.g. in construction chemistry. Further the invention relates to the use of an enzyme preparation which catalyzes the degradation of aldehydes for reducing the formaldehyde content in an aldehyde-containing formulation. Furthermore, the invention relates to a novel variant of the formaldehyde dismutase from Pseudomonas putida.Type: ApplicationFiled: March 31, 2010Publication date: February 2, 2012Inventors: Andrea Piatesi, Tilo Habicher, Michael Büschel, Li-Wen Wang, Jürgen Reichert, Rainer Packe-Wirth, Kai-Uwe Baldenius, Erich Kromm, Stefan Häfner, Carsten Schwalb, Hans Wolfgang Höffken