Patents by Inventor Kai-Wen KAN

Kai-Wen KAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11969727
    Abstract: Present invention is related to a tumor microenvironment on chip or a biochip for cell therapy having a carrier, a first cell or tissue culture area and a second cell or tissue area imbedded within the carrier. The present invention provides a biochip successfully cooperating micro fluidic technology and cell culture achieving the goal for detecting or testing the function of cell therapy for cancer or tumor.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: April 30, 2024
    Assignees: China Medical University, China Medical University Hospital
    Inventors: Yi-Wen Chen, Ming-You Shie, Der-Yang Cho, Shao-Chih Chiu, Kai-Wen Kan, Chien-Chang Chen
  • Patent number: 11806317
    Abstract: A composition comprising a grape seed extract and a black tea extract. The composition can increase testosterone secretion more effectively than a single component, and can be used for preparing pharmaceutical compositions, foods, health foods, dietary supplements or drinks used for promoting testosterone secretion.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: November 7, 2023
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, I-Hui Chen, Kai-Wen Kan, Fu Chen Liu, Ciao-Ting Chen
  • Patent number: 11752183
    Abstract: Provided is a plant extract-containing composition for reducing skin damage caused by ultraviolet radiation. The composition includes a combination of extracts of spinach, black tea, green tea, Pu-erh tea, Four Seasons Spring tea, red wine, blueberry, grape seeds, citrus, or green coffee beans.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: September 12, 2023
    Assignee: TCI CO., LTD
    Inventors: Yung-Hsiang Lin, I-Hui Chen, Kai-Wen Kan, Fu Chen Liu, Ciao-Ting Chen
  • Publication number: 20230211009
    Abstract: A method for producing exosomes in a large-scale by using a cyclic tensile bioreactor to stimulate cells to release exosomes. In addition, the exosome having an anti-HLA-G protein specific for cancer is used as a delivery vehicle to deliver therapeutic agents for treating cancer.
    Type: Application
    Filed: December 2, 2022
    Publication date: July 6, 2023
    Applicants: CHINA MEDICAL UNIVERSITY, China Medical University Hospital, Shine-On Biomedical Co., Ltd.
    Inventors: Yi-Wen Chen, Der-Yang Cho, Hsin-Yuan Fang, Ming-You Shie, Chih-Ming Pan, Kai-Wen Kan, Cheng-Yu Chen, Min-Hua Yu, Shao-Chih Chiu
  • Publication number: 20230008649
    Abstract: Present invention is related to a tumor microenvironment on chip or a biochip for cell therapy having a carrier, a first cell or tissue culture area and a second cell or tissue area imbedded within the carrier. The present invention provides a biochip successfully cooperating micro fluidic technology and cell culture achieving the goal for detecting or testing the function of cell therapy for cancer or tumor.
    Type: Application
    Filed: October 22, 2021
    Publication date: January 12, 2023
    Inventors: Yi-Wen Chen, Ming-You Shie, Der-Yang Cho, Shao-Chih Chiu, Kai-Wen Kan, Chien-Chang Chen
  • Patent number: 11278582
    Abstract: Provided is a composition for reducing the fat content of fat-producing cells and applications thereof. The composition includes plant extracts such as a blueberry extract and a black tea extract.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: March 22, 2022
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, I-Hui Chen, Kai-Wen Kan, Fu Chen Liu, Ciao-Ting Chen
  • Patent number: 10933107
    Abstract: Provided is a composition comprising a plant extract. The plant extract includes a citrus extract and a green tea extract. The extract combination can effectively increase expression of GLUT4 gene.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: March 2, 2021
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, I-Hui Chen, Kai-Wen Kan, Fu Chen Liu, Ciao-Ting Chen
  • Patent number: 10918681
    Abstract: The present disclosure provides a method for regulating expression of PDGFC, FGF2, IGF1R, PTGIS, NOS3, EDN1, PLAT, PROC, VWF, F3, SERPINE1, IL-8, ICAM1, VCAM1, and CASP8 genes, including administering to a subject in need thereof a composition including an effective amount of a plant extract, wherein the plant extract includes at least one combination selected from the group consisting of a grape seed extract and a Four seasons spring tea extract, a black tea extract and a spinach extract, the grape seed extract and the spinach extract, the grape seed extract and a green coffee bean extract, a red wine extract and a Pu-erh tea extract, and the grape seed extract and the Pu-erh tea extract.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: February 16, 2021
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, I-Hui Chen, Kai-Wen Kan, Fu Chen Liu, Ciao-Ting Chen
  • Patent number: 10918682
    Abstract: The present invention provides a method of a composition containing plant extracts for enhancing the gene expression level of TGM1, KRT, AQP3, FLG, GBA, and HAS. Compared to a single plant extract, the combination of the plant extracts of the present invention can more effectively enhance the expression level of skin moisturizing genes. The plant extracts constituting the composition include: an extract of spinach, blueberry, Pu-erh tea, or Four Seasons Spring tea.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: February 16, 2021
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, I-Hui Chen, Kai-Wen Kan, Fu Chen Liu, Ciao-Ting Chen
  • Publication number: 20200368307
    Abstract: The present invention provides a composition containing plant extracts and the use thereof. Compared to a single plant extract, the combination of the plant extracts of the present invention can effectively enhance the synthesis of collagen. The plant extracts constituting the composition include: an extract of grape seed, black tea, green tea, red wine, citrus, spinach, green coffee bean, blueberry, Pu-erh tea, or Four Seasons Spring tea.
    Type: Application
    Filed: April 3, 2018
    Publication date: November 26, 2020
    Inventors: Yung-Hsiang LIN, I-Hui CHEN, Kai-Wen KAN, Fu Chen LIU, Ciao-Ting CHEN
  • Publication number: 20200368306
    Abstract: The present disclosure provides a method for regulating expression of PDGFC, FGF2, IGF1R, PTGIS, NOS3, EDN1, PLAT, PROC, VWF, F3, SERPINE1, IL-8, ICAM1, VCAM1, and CASP8 genes, including administering to a subject in need thereof a composition including an effective amount of a plant extract, wherein the plant extract includes at least one combination selected from the group consisting of a grape seed extract and a Four seasons spring tea extract, a black tea extract and a spinach extract, the grape seed extract and the spinach extract, the grape seed extract and a green coffee bean extract, a red wine extract and a Pu-erh tea extract, and the grape seed extract and the Pu-erh tea extract.
    Type: Application
    Filed: April 3, 2018
    Publication date: November 26, 2020
    Inventors: Yung-Hsiang LIN, I-Hui CHEN, Kai-Wen KAN, Fu Chen LIU, Ciao-Ting CHEN
  • Patent number: 10786443
    Abstract: A method for protecting skin is provided, wherein the method comprises administering to a subject in need an effective amount of an orchid callus extract, and the extract is a polar solvent extract of a callus of orchid leaves. The method is especially for moisturizing skin, increasing skin tenderness, increasing skin abundance, increasing skin elasticity, tightening skin, reducing skin textures, delaying skin aging, assisting in increasing content of collagen, repairing skin tissues, preventing skin lesions, and/or promoting wound healing.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: September 29, 2020
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, Cheng-Shing Li, Kai-Wen Kan, Ciao-Ting Chen, Fu-Chen Liu
  • Publication number: 20200108280
    Abstract: Provided is a plant extract-containing composition for reducing skin damage caused by ultraviolet radiation. The composition includes a combination of extracts of spinach, black tea, green tea, Pu-erh tea, Four Seasons Spring tea, red wine, blueberry, grape seeds, citrus, or green coffee beans.
    Type: Application
    Filed: April 3, 2018
    Publication date: April 9, 2020
    Inventors: Yung-Hsiang LIN, I-Hui CHEN, Kai-Wen KAN, Fu Chen LIU, Ciao-Ting CHEN
  • Publication number: 20200054705
    Abstract: Provided is a composition comprising a plant extract. The plant extract includes a citrus extract and a green tea extract. The extract combination can effectively increase expression of GLUT4 gene.
    Type: Application
    Filed: April 3, 2018
    Publication date: February 20, 2020
    Inventors: Yung-Hsiang LIN, I-Hui CHEN, Kai-Wen KAN, Fu Chen LIU, Ciao-Ting CHEN
  • Publication number: 20200046792
    Abstract: The present invention provides a method of a composition containing plant extracts for enhancing the gene expression level of TGM1, KRT, AQP3, FLG, GBA, and HAS. Compared to a single plant extract, the combination of the plant extracts of the present invention can more effectively enhance the expression level of skin moisturizing genes. The plant extracts constituting the composition include: an extract of spinach, blueberry, Pu-erh tea, or Four Seasons Spring tea.
    Type: Application
    Filed: April 3, 2018
    Publication date: February 13, 2020
    Inventors: Yung-Hsiang LIN, I-Hui CHEN, Kai-Wen KAN, Fu Chen LIU, Ciao-Ting CHEN
  • Publication number: 20200038468
    Abstract: Provided is a composition for reducing the fat content of fat-producing cells and applications thereof. The composition includes plant extracts such as a blueberry extract and a black tea extract.
    Type: Application
    Filed: April 3, 2018
    Publication date: February 6, 2020
    Inventors: Yung-Hsiang LIN, I-Hui CHEN, Kai-Wen KAN, Fu Chen LIU, Ciao-Ting CHEN
  • Publication number: 20200030396
    Abstract: A composition comprising a grape seed extract and a black tea extract. The composition can increase testosterone secretion more effectively than a single component, and can be used for preparing pharmaceutical compositions, foods, health foods, dietary supplements or drinks used for promoting testosterone secretion.
    Type: Application
    Filed: April 3, 2018
    Publication date: January 30, 2020
    Inventors: Yung-Hsiang LIN, I-Hui CHEN, Kai-Wen KAN, Fu Chen LIU, Ciao-Ting CHEN
  • Publication number: 20190307827
    Abstract: A method for inhibiting the expression of ICAM-1 gene is provided, wherein the method comprises administering to a subject in need an effective amount of an euryale seed extract. The method is especially for treating, preventing or regulating diseases or physiological functions associated with ICAM-1 gene.
    Type: Application
    Filed: August 14, 2018
    Publication date: October 10, 2019
    Inventors: Yung-Hsiang LIN, Cheng-Shing LI, Kai-Wen KAN, Ciao-Ting CHEN, Fu-Chen LIU
  • Publication number: 20180296627
    Abstract: The present invention provides a method for reducing the expressions of the sterol regulatory element-binding protein 1C (SREBP-1C), acetyl-CoA carboxylase (ACC), and stearoyl-CoA desaturase 1 (SCD-1), comprising administering to a subject a composition comprising an effective amount of a longan pericarp extract. The longan pericarp extract significantly inhibits lipogenesis, reduces the glutamic-pyruvic transaminase (GPT) index, and protects the liver.
    Type: Application
    Filed: April 9, 2018
    Publication date: October 18, 2018
    Inventors: Yung-Hsiang Lin, I-Hui Chen, Kai-Wen Kan
  • Publication number: 20180289613
    Abstract: A method for protecting skin is provided, wherein the method comprises administering to a subject in need an effective amount of an orchid callus extract, and the extract is a polar solvent extract of a callus of orchid leaves. The method is especially for moisturizing skin, increasing skin tenderness, increasing skin abundance, increasing skin elasticity, tightening skin, reducing skin textures, delaying skin aging, assisting in increasing content of collagen, repairing skin tissues, preventing skin lesions, and/or promoting wound healing.
    Type: Application
    Filed: April 4, 2018
    Publication date: October 11, 2018
    Inventors: Yung-Hsiang LIN, Cheng-Shing LI, Kai-Wen KAN, Ciao-Ting CHEN, Fu-Chen LIU