Patents by Inventor Kai Wen Teng

Kai Wen Teng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective and Noncovalent Inhibitors of Oncogenic RAS Mutants
    Publication number: 20220177531
    Abstract: Provided are proteins or peptides, which may be referred to as monobodies. Fusion proteins and proteolysis targeting chimeras (PROTACs) comprising the proteins or peptides are also provided. Also provided are compositions of the proteins or peptides of the present disclosure, as well as compositions of fusion proteins and compositions of PROTACs. Methods of treating an individual in need of treatment are also provided. The methods may be to treat an individual suffering from or suspected of having KRAS(G12V), KRAS(G12S), KRAS(G12A) and/or KRAS(G12C)-associated cancers. A method may be for inhibiting ERK activation and/or proliferation of KRAS(G12V), KRAS(G12S), KRAS(G12A) and/or KRAS(G12C)-associated cancers.
    Type: Application
    Filed: December 6, 2021
    Publication date: June 9, 2022
    Inventors: Shohei Koide, Kai Wen Teng, Akiko Koide, Takamitsu Hattori