Patents by Inventor Kaidong Zhang

Kaidong Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and systems for evaluating and predicting the reactivity of monooxygenase enzymes
    Patent number: 9273342
    Abstract: Methods and systems for evaluating and predicting the reactivity of natural and engineered monooxygenase enzymes are provided. Methods are provided for acquiring a functional profile (fingerprint) of monooxygenases that encode information regarding the active site configuration of such monooxygenases. Methods are also provided for carrying out analysis of a monooxygenase fingerprint, to formulate predictions regarding the reactivity properties (e.g., substrate reactivity, chemo-, regio, and stereoselectivity properties) of the fingerprinted monooxygenases.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: March 1, 2016
    Assignee: University of Rochester
    Inventors: Rudi Fasan, Kaidong Zhang
  • METHODS AND SYSTEMS FOR EVALUATING AND PREDICTING THE REACTIVITY OF MONOOXYGENASE ENZYMES
    Publication number: 20140038850
    Abstract: Methods and systems for evaluating and predicting the reactivity of natural and engineered monooxygenase enzymes are provided. Methods are provided for acquiring a functional profile (fingerprint) of monooxygenases that encode information regarding the active site configuration of such monooxygenases. Methods are also provided for carrying out analysis of a monooxygenase fingerprint, to formulate predictions regarding the reactivity properties (e.g., substrate reactivity, chemo-, regio, and stereoselectivity properties) of the fingerprinted monooxygenases.
    Type: Application
    Filed: February 10, 2012
    Publication date: February 6, 2014
    Applicant: University of Rochester
    Inventors: Rudi Fasan, Kaidong Zhang
  • Synthesis of carbohydrate-templated amino acids and methods of using same
    Patent number: 7951905
    Abstract: The present invention generally relates to tetrahydropyranyl-derivatized amino acids, their syntheses and their incorporation into peptides and peptidomimetics. The tetrahydropyran moiety constrains the side chain of an amino acid, thereby providing a molecule that may act as a sugar- or amino acid-mimetic as well as a scaffold for combinatorial synthesis.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: May 31, 2011
    Assignee: University of Manitoba
    Inventors: Frank Schweizer, Kaidong Zhang, Neil Owens, George Zhanel
  • Peptide-Based Beta Turn Mimetics
    Publication number: 20100256333
    Abstract: Beta-mimetic compositions and methods of making and using such compositions in preparing bioactive peptides, such as antimicrobial peptides, are disclosed. In particular, spirocyclic proline hybrids are provided that may be used to alter the cis/trans isomerization of proline in a peptide, and which may replace a residue, for example, the i+2 residue, of a beta-turn in a peptide of known sequence, thereby retaining or modifying the structure of the peptide.
    Type: Application
    Filed: April 1, 2010
    Publication date: October 7, 2010
    Applicant: UNIVERSITY OF MANITOBA
    Inventors: Kaidong Zhang, Frank Schweizer
  • Synthesis of Carbohydrate-Templated Amino Acids and Methods of Using Same
    Publication number: 20080275213
    Abstract: The present invention generally relates to tetrahydropyranyl-derivatized amino acids, their syntheses and their incorporation into peptides and peptidomimetics. The tetrahydropyran moiety constrains the side chain of an amino acid, thereby providing a molecule that may act as a sugar- or amino acid-mimetic as well as a scaffold for combinatorial synthesis.
    Type: Application
    Filed: September 18, 2007
    Publication date: November 6, 2008
    Applicant: UNIVERSITY OF MANITOBA
    Inventors: Frank Schweizer, Kaidong Zhang, Neil Owens, George Zhanel