Abstract: A circuit provides fail safe protection of an input/output (I/O) circuit of a chip. The I/O circuit comprises an I/O pad connected to one or more other chips via an I/O bus. The circuit comprise a supply and failsafe detector component. The supply and failsafe detector component generates an I/O supply output signal. The I/O supply output signal has a low voltage value when the I/O supply voltage of the chip is below a medium voltage level and the I/O supply output signal having a high voltage value when the I/O supply voltage of the chip is above the medium voltage level. The medium voltage is above a threshold voltage of the transistor of the I/O circuit and below the high voltage value. The circuit uses the I/O supply output signal to provide a reference voltage as input to the transistor of the I/O circuit.

Abstract: The subject invention pertains to methods and compositions for treating hypertension. In specific embodiments, the methods comprise administering KSD179019 to a subject in need of hypertension treatment. In further embodiments, the methods comprise administering a KSD179019 analog or derivative to a subject in need of hypertension treatment. Also provided are methods to design and manufacture KSD179019 analogs and derivatives with enhanced and prolonged anti-hypertensive therapeutic efficacy.

Abstract: Compounds that have antiallergic and/or anti-inflammatory properties and methods of making thereof are disclosed. These compounds can block MMRGPRX2 and prevent or reduce mast cells activation. Pharmaceutical formulations in a unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical formulations may include one or more active agents in addition to the compounds, such as one or more additional antiallergic and/or anti-inflammatory agents. The pharmaceutical formulation can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating pseudo allergic reactions, pseudo allergic diseases, and/or pseudo inflammatory diseases, or treating or ameliorating one or more symptoms associated with a pseudo allergic reaction, a pseudo allergic disease, and/or a pseudo inflammatory disease in a subject are also disclosed.

Abstract: A new and distinct hybrid plant named `Himalaya` (Mentha arvensis) characterized by its higher yield of oil which is rich in menthol, improved regeneration potential, vigorous growth, deep green broad thick leaves, pinkish white flowers and tolerance to rust such as alternaria leaf blight, corynespora leaf spot and powdery mildew.