Abstract: A device suitable for forming spherical particle clusters from fine powder is a device through which spherical particle clusters having a controlled particle size and a controlled hardness can be prepared from the fine powder by using a rolling granulation principle without adding any solution or solid binder. In particular, the device includes the following components: a) a preforming device for preforming particle clusters formed from fine powder, so that the particle clusters have a certain strength and shape while conveying the particle clusters to a next step at a certain speed; b) a spheroidizing device for further strengthening the particle clusters formed by a) the preforming device, so that the particle clusters have a higher sphericity and hardness; and c) a grading device for sieving the particle clusters spheroidized by b) the spheroidizing device to obtain particle clusters of different particle size ranges.

Abstract: A powder rotary fluidization device and a method thereof are provided. The powder rotary fluidization device includes a support device, the support device is provided with an installing plate, the installing plate is provided with a power device and a fluidization device, and the power device is in transmission connection with the fluidization device. After a position of the fluidization device on the installing plate is adjusted through the support device, the power device is started to drive the fluidization device to rotate, and meanwhile gases are introduced into the fluidization device to process powder. and therefore the problem of poor processing effect on fine powder with high viscosity is solved through the rotatable fluidization device.

Abstract: Provided are a metformin inhalation powder aerosol for treating idiopathic pulmonary fibrosis and a preparation method thereof, including following steps: pretreating a metformin raw material to obtain fine powder, and passing the obtained fine powder through a screen with a mesh size of 100-1000 microns by an pendular granulator at a rotating speed of 200 revolutions per minute to obtain soft particle clusters; pre-spheronizing clusters at a vibration frequency of 100-300 hertz to obtain particle clusters, and then rolling the particle clusters on a granulating pan and spheronizing to obtain spherical particle clusters.

Abstract: A dry powder coating apparatus for coating pharmaceutical solid dosage forms includes a housing; a drum coater; a powder coating system; a liquid spray system; a ventilation system; a heating system; a touch screen control panel; and an operation box. The drum coater may have a truncated cone on both sides, in which one side is opened and another side is closed. The drum coater is horizontally placed inside the operation box along its axis and fixed on a rotatable shaft and a motor drives the rotatable shaft and rotates the drum coater about its own axis.

Abstract: A dry powder coating apparatus for coating pharmaceutical solid dosage forms includes a housing; a drum coater; a powder coating system; a liquid spray system; a ventilation system; a heating system; a touch screen control panel; and an operation box. The drum coater may have a truncated cone on both sides, in which one side is opened and another side is closed. The drum coater is horizontally placed inside the operation box along its axis and fixed on a rotatable shaft and a motor drives the rotatable shaft and rotates the drum coater about its own axis.

Abstract: The present disclosure provides a product of coated nutrients for controlled release, a method for coating the nutrients for controlled release and a coating composition for coating the nutrients for controlled release.

Abstract: Methods for preparing the drug-coated implants include a) providing an implant; b) coating the implant with the first material which includes active pharmaceutical ingredients and the first biocompatible sustained-release polymer materials; c) coating the implant with the second material which includes the second biocompatible sustained-release polymer materials. The methods can be used to prepare a drug-coated implant and a drug coating layer.

Abstract: A method of preparing 6-chloro-5-nitro-2,4-diaminopyrimidine includes: reacting guanidine hydrochloride with ethyl carbamoylacetate and sodium hypochlorite in the presence of a metal nitrate salt and acetate anhydride in an organic solvent.

Abstract: A compound having the following formula I: In formula I, R1 and R2 are independently H, alkyl, alkoxy, and halogen. A method of preparing the compound of formula I is also disclosed.