Abstract: The present disclosure relates to crystalline form CS3 of ozanimod hydrochloride which can be used for treating autoimmune diseases, particularly used for preparing drugs for treating multiple sclerosis and ulcerative colitis and preparation method thereof.

Abstract: A method for evaluating the breakage strength of first and second cemented surfaces of well cementation under a dynamic load, includes: producing a rock-set cement-casing composite structure sample; clamping the sample between an incident rod and an output rod of a Hopkinson rod, hitting the incident rod with a conical punch to generate incident waves, enabling the incident waves to pass through the sample to generate reflected waves and projected waves, recording dynamic strain signals of incident waves, reflected waves and projected waves, and converting the dynamic strain signals into electrical signals and transmitting the electrical signals to a computer; recording the process and the corresponding time point from breakage starting to a complete breakage of the first and second cemented surfaces by a photographic instrument; obtaining a strain rate time travel curve and a stress-strain curve, and obtaining the corresponding breakage strength by analyzing the curve peak points.

Abstract: An oil well cement slurry high-temperature suspension stabilizer prepared from oil-based shale drilling cuttings is provided. The high-temperature suspension stabilizer is reasonable in principle, inexpensive and easily available in raw materials, high in product uniformity and good in chemical stability. Meanwhile, waste is changed into wealth. Therefore, the high-temperature suspension stabilizer is environment-friendly and has a broad industrial application prospect.

Abstract: A method and apparatus for position detection, and a radiotherapy system are provided. The radiotherapy system includes: a treatment couch, a positioning apparatus, an optical tracking system and a computer; the positioning apparatus disposed on the treatment couch, and at least one reference point provided on the positioning apparatus; the optical tracking system disposed above the treatment couch and configured to detect relative positioning between a mark point set on a treated part of a patient and the reference point, determine deviation between the relative and reference positions, and send the deviation to the computer. The computer is configured to determine whether to adjust a position of the treatment couch based on the deviation and deviation range. The system provided by the present disclosure avoids the influence of patient movement on the accuracy of treatment, and prevents a treatment beam from damaging normal tissues of the patient.

Abstract: The present invention relates to a method for preparing an intermediate (Formula IV) of sodium elagolix. The intermediate is prepared by the following route. The method has advantages of simple and safe operation, high yield, less environmental pollution, good economic effect and suitability for industrial production, wherein R represents C1-C4 substituted or unsubstituted benzyl or allyl.

Abstract: The present disclosure is related to crystalline forms of ozanimod hydrochloride, as well as preparation method thereof. The crystalline form of ozanimod hydrochloride provided by the present disclosure can be used for treating autoimmune diseases, particularly multiple sclerosis and ulcerative colitis. The crystalline form of the present disclosure has advantages in at least one aspect of solubility, melting point, stability, dissolution, bioavailability and processability and provides a new and better choice for the preparation of drug product containing ozanimod, and has significant value for drug development.

Abstract: The present disclosure relates to novel crystalline forms of an androgen receptor antagonist drug (ODM-201 represented by formula (I)), preparation method thereof and use thereof. The crystalline form B or the crystalline form C of ODM-201 provided by the present disclosure has low hygroscopicity, good stability, high solubility, excellent flowability, optimal particle size with uniform distribution, which provides a new choice for the preparation of drugs containing ODM-201 and is of great value for drug development.

Abstract: A method configured to implemented on at least one map processing device for determining new roads on a map includes obtaining a first road network image of a region, the first road network image including a first plurality of roads. The method also includes determining a second road network image of the region based on a map of the region, the second road network image including a second plurality of roads that are not present in the first road network image. The method further includes determining a third road network image by concatenating the first road network image and the second road network image. The method still further includes determining a fourth road network image of the region by processing the third road network with at least one convolution layer, the fourth road network including the second plurality of roads.

Abstract: The present disclosure relates to novel crystalline forms of a bromodomain protein inhibitor 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one and processes for preparation and use thereof, relating to pharmaceutical industry. Form CS2, Form CS8, Form CS13, Form CS20, Form CS1, Form CS7, Form CS9, Form CS11 and Form CS4 of the present disclosure can be used for preparing drugs treating cardiovascular, cholesterol or lipid-related disorders.

Abstract: The present disclosure relates to systems and methods for identifying one or more target roads. The systems may perform the methods to obtain a heat map associated with a plurality of driving track points along a plurality of roads in a target region, wherein the plurality of roads includes one or more target roads and one or more reference roads; obtain a road network map associated with the one or more reference roads in the target region; produce an intermediate heat map by: eliminating pixels in the heat map corresponding to the one or more reference roads in the road network map, eliminating background pixels corresponding to background of the heat map, and thinning the heat map; and determine start coordinate information and end coordinate information associated with the one or more target roads based on the intermediate heat map according to a linear transformation.

Abstract: A resin tank applicable to a photocuring 3D printer includes: a tank body for containing a liquid photosensitive resin, at least one side wall of the tank body being an optically-transmissive wall; a transverse guide element arranged on the tank body; and a load-bearing element arranged inside the tank body and movable transversely along the guide element, wherein a load-bearing surface of the load-bearing element faces the optically-transmissive wall.

Abstract: An anode, which includes a current collector and an anode material stack coated on the current collector, the anode material stack includes an anode active material layer, which includes porous carbon material and a first binder, and the porous carbon material is mixed with the binder. The anode material stack further includes a carbon intermediate layer sandwiched between the current collector and the anode active material layer. It also provides a method for preparing the anode. Further, it provides a lithium ion battery including the anode above.

Abstract: The present disclosure relates to novel crystalline forms of an androgen receptor antagonist drug (ODM-201 represented by formula (I)), preparation method thereof and use thereof. The crystalline form B or the crystalline form C of ODM-201 provided by the present disclosure has low hygroscopicity, good stability, high solubility, excellent flowability, optimal particle size with uniform distribution, which provides a new choice for the preparation of drugs containing ODM-201 and is of great value for drug development.

Abstract: The present disclosure relates to novel crystalline forms of ozanimod and preparation method thereof. The provided crystalline forms of ozanimod comprise crystalline form CS9, crystalline form CS10 and crystalline form CS11, and can be used for treating autoimmune diseases, particularly used for preparing drugs for treating multiple sclerosis and ulcerative colitis. The crystalline forms of the present disclosure have one or more advantages in solubility, stability, hygroscopicity and processability and provide new and better choices for the preparation of ozanimod drug product, and are very valuable for drug development.

Abstract: The present disclosure is directed to novel crystalline forms of ozanimod and ozanimod hydrochloride, as well as preparation method thereof. Said crystalline forms of ozanimod and ozanimod hydrochloride can be used for treating autoimmune diseases, particularly used for preparing drugs for treating multiple sclerosis and ulcerative colitis. The crystalline forms of the present disclosure have one or more advantages in solubility, melting point, stability, dissolution, bioavailability and processability and provide new and better choices for the preparation of ozanimod drug product, and are very valuable for drug development.

Abstract: A robot arm and a transfer robot are disclosed. In one embodiment, a robot arm includes an arm body and a plurality of adjustment units. The arm body has a first carrying surface and defines a length direction along which a length of the arm body is in and a width direction along which a width of the arm body is in. The adjustment units is disposed on at least one side of the arm body in the width direction. Each adjustment unit includes: a connection member fixed to the arm body, and an adjustment member movably connected to the connection member and having a second carrying surface that is parallel to the first carrying surface. The adjustment member is movable relative to the connection member in the width direction so that the second carrying surface is adjustable in the width direction.

Abstract: A well cementation working solution prepared from red mud, slag and waste drilling fluids. The working solution is prepared from the following components in parts by weight: 100 parts of waste drilling fluids, 50-100 parts of slag, 5-50 parts of red mud, 4-7 parts of a suspension stabilizer, 1-7 parts of an activating aid, 0.5-5 parts of an anti-pollution agent and 0.4-3.5 parts of a diluent. The waste drilling fluids are waste waterborne drilling fluids. The slag is blast furnace slag or vanadium-titanium slag. The suspension stabilizer is sodium bentonite, carboxymethyl cellulose or a mixture of sodium bentonite and carboxymethyl cellulose. The activating aid is sodium metasilicate nonahydrate, sodium carbonate or a mixture of sodium metasilicate nonahydrate and sodium carbonate. The anti-pollution agent is sodium salicylate, potassium citrate or a mixture of sodium salicylate and potassium citrate. The diluent is sodium lignin sulfonate.