Patents by Inventor Kaishu Momonoi
Kaishu Momonoi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5380878Abstract: This invention relates to a process for producing a compound represented by formula (6a) or (6b): ##STR1## wherein R.sup.2 represents a hydrogen atom or a hydroxyl-protecting group and R.sup.4 and R.sup.5, which may be the same or different, represents lower alkyl groups, using a compound represented by formula (2a) or (2b) obtained by preferential crystallization: ##STR2## and also to a compound represented by the following formula (7) which is an intermediate useful for producing the compound of formula (6a) or (6b): ##STR3## wherein R.sup.1 represents a group represented by formula (8): ##STR4## wherein R.sup.2 and R.sup.3 is as defined above and R.sup.3 represents a hydrogen atom, a group or a carboxyl protecting group represented by formula (9): ##STR5## or a group represented by formula (10): ##STR6## wherein R.sup.2 is as defined above.Type: GrantFiled: March 29, 1994Date of Patent: January 10, 1995Assignee: Toyama Chemical Co., Ltd.Inventors: Joji Nakano, Nobuhisa Taya, Hisaaki Chaki, Tetsuo Yamafuji, Kaishu Momonoi
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Patent number: 5300497Abstract: A penam derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom, an amino-protecting group or an acyl group; R.sup.2 represents a hydrogen atom or a lower alkyl group; R.sup.3 represents a hydrogen atom, a lower alkoxy group, a lower alkylthio group or a formamido group; R.sup.4 represents an protected or unprotected carboxyl group or a carboxylato group; R represents a group of the formula, --NHR.sup.5 or --NR.sup.5 R.sup.6 (in which R.sup.5 and R.sup.6, which may be the same or different, represent protected or unprotected hydroxyl groups, cyano groups, sulfo groups, or unsubstituted or substituted lower alkyl, aryl, acyl, carbamoyl, sulfamoyl, lower alkylsulfonyl or heterocyclic groups) or a group of the formula, --N.dbd.CR.sup.7 R.sup.8 (in which R.sup.7 and R.sup.Type: GrantFiled: October 7, 1992Date of Patent: April 5, 1994Assignee: Toyama Chemical Co., Ltd.Inventors: Hirokazu Ochiai, Yasuo Watanabe, Yoshiharu Murotani, Hirohiko Fukuda, Osamu Yoshino, Shinzaburo Minami, Toshio Hayashi, Kaishu Momonoi
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Patent number: 5185330Abstract: A penam derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom, an amino-protecting group or an acyl group; R.sup.2 represents a hydrogen atom or a lower alkyl group; R.sup.3 represents a hydrogen atom, a lower alkoxy group, a lower alkylthio group or a formamido group; R.sup.4 represents a protected or unprotected carboxy group or a craboxylato group; R represents a group of the formula, --NHR.sup.5 or --NR.sup.5 R.sup.6 (in which R.sup.5 and R.sup.6, which may be the same or different, represent protected or unprotected hydroxyl groups, cyano groups, sulfo groups, or unsubstituted or substituted lower alkyl, aryl, acyl, carbamoyl, sulfamoyl, lower alkylsulfonyl or heterocyclic groups) or a group of the formula, --N.dbd.CR.sup.7 R.sup.8 (in which R.sup.7 and R.sup.Type: GrantFiled: June 20, 1990Date of Patent: February 9, 1993Assignee: Toyama Chemical Co., Ltd.Inventors: Hirokazu Ochiai, Yasuo Watanabe, Yoshiharu Murotani, Hirohiko Fukuda, Osamu Yoshino, Shinzaburo Minami, Toshio Hayashi, Kaishu Momonoi
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Patent number: 4731370Abstract: This invention relates to a novel 1,4-dihydropyridine derivative of the formula ##STR1## wherein R2 is pyridyl, or a salt thereof. These compounds have a vasodilating activity and a platelet aggregation inhibiting activity. Also disclosed are pharmaceutical compositions containing the same.Type: GrantFiled: June 10, 1986Date of Patent: March 15, 1988Assignee: Toyama Chemical Co., Ltd.Inventors: Isao Watanabe, Kaishu Momonoi, Toru Hiraiwa, Satoshi Ono, Joji Nakano, Katsuyuki Nagumo, Hiroyasu Takagi
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Patent number: 4713387Abstract: This invention relates to a 1,4-dihydropyridine derivative of the formula ##STR1## wherein Y represents an oxygen or sulfur atom or a vinylene group, Z represents an oxygen or sulfur atom or an alkylene group, R.sup.2 represents an imidazolyl or pyridyl group and the remaining substituents are herein defined. These compounds have a vasodilating activity and a platelet aggregation inhibiting activity.Type: GrantFiled: June 21, 1985Date of Patent: December 15, 1987Assignee: Toyama Chemical Co., Ltd.Inventors: Isao Watanabe, Kaishu Momonoi, Toru Hiraiwa, Satoshi Ono, Joji Nakano, Katsuyuki Nagumo, Hiroyasu Takagi
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Patent number: 4410522Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group in molecule. These compounds are valuable antibacterial compounds for use in mammals including man. This disclosure relates to such compounds and a process for the preparation thereof.Type: GrantFiled: October 12, 1977Date of Patent: October 18, 1983Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 4385178Abstract: This disclosure relates to a novel process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids which are intermediate products of cephalosporins being valuable antibacterial compounds for use in mammals including man.Type: GrantFiled: December 17, 1981Date of Patent: May 24, 1983Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Seietsu Kuroda, Kiyoshi Tanaka, Kenshin Hayashi, Bunei Nagahashi, Chiaki Kutani
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Patent number: 4379152Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group in molecule. These compounds are valuable antibacterial compounds for use in mammals including man. This disclosure relates to such compounds and a process for the preparation thereof.Type: GrantFiled: May 17, 1979Date of Patent: April 5, 1983Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 4327097Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable anti-bacterial compounds for use in mammals including man. A process for the preparation of the compounds has also been discovered.Type: GrantFiled: June 12, 1979Date of Patent: April 27, 1982Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 4317907Abstract: This disclosure relates to a novel process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids which are intermediate products of cephalosporins being valuable antibacterial compounds for use in mammals including man.Type: GrantFiled: February 2, 1978Date of Patent: March 2, 1982Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Seietsu Kuroda, Kiyoshi Tanaka, Kenshin Hayashi, Bunei Nagahashi, Chiaki Kutani
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Patent number: 4312986Abstract: This disclosure relates to a novel process for producing 7-(substituted)-amino-3-substituted thiomethyl-.DELTA..sup.3 -cephem-4-carboxylic acids which are intermediate products of cephalosporins being valuable antibacterial compounds for use in mammals including man.Type: GrantFiled: July 5, 1979Date of Patent: January 26, 1982Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Seietsu Kuroda, Kiyoshi Tanaka, Kenshin Hayashi, Bunei Nagahashi, Chiaki Kutani
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Patent number: 4304909Abstract: The N,N-dimethylacetamide adduct of 7-[D(-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-.alpha.-(4-hyd roxyphenyl)acetamido]-3-[5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl]-.DELTA. .sup.3 -cephem-4-carboxylic acid, a process for the production thereof, and a process for producing said acid and a pharmaceutically acceptable salt thereof through said adduct.Type: GrantFiled: August 24, 1979Date of Patent: December 8, 1981Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Chiaki Kutani, Kiyoshi Tanaka, Kenshin Hayashi
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Patent number: 4237280Abstract: The N,N-dimethylacetamide adduct of 7-[D(-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-.alpha.-(4-hyd roxyphenyl)acetamido]-3-[5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl]-.DELTA. .sup.3 -cephem-4-carboxylic acid, a process for the production thereof, and a process for producing said acid and a pharmaceutically acceptable salt thereof through said adduct.Type: GrantFiled: September 25, 1978Date of Patent: December 2, 1980Assignee: Toyama Chemical Company, LimitedInventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Chiaki Kutani, Kiyoshi Tanaka, Kenshin Hayashi
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Patent number: 4219554Abstract: Novel penicillins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable antibacterial compounds for use in mammals including man. A process for the preparation of the compounds has also been discovered.Type: GrantFiled: June 15, 1978Date of Patent: August 26, 1980Assignee: Toyama Chemical Company, LimitedInventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 4112090Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable antibacterial compounds for use in mammals including man. A process for the preparation of the compounds has also been discovered.Type: GrantFiled: January 30, 1976Date of Patent: September 5, 1978Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 4110327Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group in molecule. These compounds are valuable antibacterial compounds for use in mammals including man. This disclosure relates to such compounds and a process for the preparation thereof.Type: GrantFiled: October 15, 1976Date of Patent: August 29, 1978Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 4087424Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group in molecule. These compounds are valuable antibacterial compounds for use in mammals including man. This disclosure relates to such compounds and a process for the preparation thereof.Type: GrantFiled: April 24, 1975Date of Patent: May 2, 1978Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 3981865Abstract: Novel bis-type penicillins containing a (thio)acylureido group in the molecule, which are valuable antibacterial compounds for use in mammals including a human being.This disclosure relates to such compounds and a process for the preparation thereof.Type: GrantFiled: June 11, 1975Date of Patent: September 21, 1976Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Kyoko Kasuya, Yutaka Kodama