Patents by Inventor Kaitlin Grace Frances Winter

Kaitlin Grace Frances Winter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VACCINE AND METHOD OF VACCINATION AGAINST CLOSTRIDIUM DIFFICILE USING A LIVE BACTERIAL VECTOR
    Publication number: 20200093912
    Abstract: An attenuated Salmonella enterica serovar Typhimurium strain (YS1646) is repurposed to produce a vaccine. Plasmid-based candidates expressing either the TcdA or TcdB RBD were screened. Different vaccine routes and schedules were tested to achieve detectable serum and mucosal antibody titers in C57BL/6J mice. When given in a multi-modality schedule over 1 week (day 0 IM+PO, days 2 and 4 PO), several candidates provided 100% protection against lethal challenge. Substantial protection (82%) was achieved with combined PO TcdA/TcdB vaccination alone (d0, 2 and 4). These data demonstrate the potential of the YS1646-based vaccines for C. difficile.
    Type: Application
    Filed: September 19, 2019
    Publication date: March 26, 2020
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Brian J. Ward, Kaitlin Grace Frances Winter