Patents by Inventor Kaixian Chen

Kaixian Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7456205
    Abstract: The invention relates to the benzopyran compounds of formula (I), or the salts thereof, in which, the bond between 3 and 4 positions is a single or double bond; R1 represents a hydrogen atom or a C1-6 alkyl that can be substituted; R2 represents a hydrogen atom, a C1-6 alkyl that can be substituted or an aromatic carbocyclic or aromatic heterocyclic group that can be substituted. The invention also relates to a process for preparing such compounds or their salts as well as the use of such compounds or their salts in the preparation of the medicine against type II diabetes mellitus.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: November 25, 2008
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Yushe Yang, Lei Tang, Ruyun Ji, Kaixian Chen
  • Publication number: 20060178405
    Abstract: The invention relates to the benzopyran compounds of formula (I), or the salts thereof, in which, the bond between 3 and 4 positions is a single or double bond; R1 represents a hydrogen atom or a C1-6 alkyl that can be substituted; R2 represents a hydrogen atom, a C1-6 alkyl that can be substituted or an aromatic carbocyclic or aromatic heterocyclic group that can be substituted. The invention also relates to a process for preparing such compounds or their salts as well as the use of such compounds or their salts in the preparation of the medicine against type II diabetes mellitus.
    Type: Application
    Filed: February 26, 2003
    Publication date: August 10, 2006
    Inventors: Yushe Yang, Lei Tang, Ruyun Ji, Kaixian Chen
  • Publication number: 20060154970
    Abstract: The present invention provides alanines compounds of formula (I) or their salts: In the formula (I), the configuration of ?-Carbon atom of alanine is R or S; R1 is hydrogen, unsubstituted or substituted C1-6alkyl, unsubstituted or substituted aryl or aromatic heterocyclic group; R2 is hydrogen or unsubstituted or substituted C1-6 alkyl. The present invention also provides two methods of preparing these compounds or their salts, and their use in preparing anti II type diabetic medicine.
    Type: Application
    Filed: January 28, 2003
    Publication date: July 13, 2006
    Inventors: Yushe Yang, Lei Tang, Ruyun Ji, Kaixian Chen
  • Publication number: 20060142383
    Abstract: The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.
    Type: Application
    Filed: December 2, 2005
    Publication date: June 29, 2006
    Inventors: Jianhua Shen, Hualiang Jiang, Xu Shen, Jianping Zuo, Xiaomin Luo, Donglu Bai, Jingkang Shen, Kaixian Chen, Chunshan Gui, Lili Chen, Jing Chen, Yifu Yang, Xianhan Zhuang, Yiming Yang, Xuchang He, Hong Liu, Bing Xiong, Haibin Luo, Tao Sun, Fei Ye