Abstract: Friction devices and systems for dissipating energy from a structure are provided. In various embodiments, the friction device may include a first friction assembly including a first plate and a second plate and configured to generate a first friction force by a movement of the first plate relative to the second plate; a first fastener assembly configured to exert a first normal force onto the first friction assembly; a second friction assembly including auxiliary pads and configured to generate a second friction force by a movement of the auxiliary pads relative to the second plate when the auxiliary pads are coupled to the first plate; and a second fastener assembly configured to exert a second normal force onto the second friction assembly, in which energy is dissipated by a total friction force that is a sum of the first friction force and the second friction force and discretely variable.

Abstract: An isolated anti-CD47 antibody or fragment thereof has the ability of binding CD47 and competing with the binding of SIRPa to CD47, and comprises a heavy chain variable region comprising heavy chain complementarity determining regions HCDR1, HCDR2, and HCDR3; and a light chain variable region comprising light chain complementarity determining regions LCDR1, LCDR2, and LCDR3. A method for treating a disorder in which CD47 is overexpressed or upregulated in a subject, comprises using an isolated anti-CD47 antibody or fragment thereof having the ability of binding CD47 and competing with the binding of SIRPa to CD47. A bispecific antibody comprises a first antigen binding moiety that binds to human GPC3 (hGPC3); and a second antigen binding moiety that binds to human CD47 (hCD47).

Abstract: A method for preparing compound or biological drug enhancing CNPase activity for treating heart diseases. The chemical method relates to using kaurane compounds to up-regulating the expression and activity of CNPase. Biological therapeutic drugs related to the preparation of CNPase enzyme expressed by using recombinant adeno-associated virus and local interventional therapy. In a rat myocardial hypertrophy and heart failure model, the methods can effectively improve myocardial hypertrophy, myocardial remodeling, inhibit myocardial hypertrophy and fibrosis, and increase cardiac function.

Abstract: An offline uninterruptible power supply (UPS) is provided, including: a transformer, configured to output a utility power voltage to a load; a bidirectional converter, configured to convert alternating current from the transformer into direct current to charge a rechargeable battery, and convert direct current from the rechargeable battery into alternating current to be outputted to the transformer; and a control unit, configured to control operation of the offline UPS, where when the utility power voltage is within a normal range and the rechargeable battery is fully charged, the offline UPS enters a design of energy (DOE) mode, in the DOE mode, the transformer and the bidirectional converter are turned off, and in the DOE mode, the control unit is configured to detect a voltage of the rechargeable battery, and calculate a slope of decrease in the voltage of the rechargeable battery, and when the slope of decrease in the voltage is greater than a preset first threshold, the control unit controls the offline

Abstract: An auxiliary sensing method and system based on sensory substitution includes: establishing a discrete horizontal plane included angle and a normal vector included angle in three-dimensional space as well as response functions corresponding to different discrete distances, and establishing an acoustic coding library of an object; obtaining a surrounding environmental video; obtaining object information and category of current environment; establishing a three-dimensional sound field of the object according to the image information, the object information and the three-dimensional coordinate information obtained in combination with the acoustic coding library of the object; and adjusting, for objects of different categories, the three-dimensional sound field of each object according to movement information and variations of images, and playing the three-dimensional sound field of each object in real time.

Abstract: An auxiliary sensing method and system based on sensory substitution includes: establishing a discrete horizontal plane included angle and a normal vector included angle in three-dimensional space as well as response functions corresponding to different discrete distances, and establishing an acoustic coding library of an object; obtaining a surrounding environmental video; obtaining object information and category of current environment; establishing a three-dimensional sound field of the object according to the image information, the object information and the three-dimensional coordinate information obtained in combination with the acoustic coding library of the object; and adjusting, for objects of different categories, the three-dimensional sound field of each object according to movement information and variations of images, and playing the three-dimensional sound field of each object in real time.