Abstract: Provided are a humanized antibody specifically binding to EpCAM, and a chimeric antigen receptor, a nucleic acid, a vector, a cell, and the use associated with the humanized antibody. The humanized antibody comprises a heavy chain variable region and a light chain variable region. The sequence of the heavy chain variable region comprises a sequence shown in SEQ ID.1, a sequence shown in SEQ ID.2 and a sequence shown in SEQ ID.3. The sequence of the light chain variable region comprises a sequence shown in SEQ ID.4, a sequence shown in SEQ ID.5, and a sequence shown in SEQ ID.6. After the humanized antibody is constructed as a chimeric antigen receptor-T Cell, EpCAM-positive tumor cells can be specifically identified and killed, and tumors can be cleared in an animal body.

Abstract: An example for determining consensus by Parallel Proof of Voting (PPoV) in a consortium blockchain includes causing each bookkeeping node to generate and publish a block to a consortium blockchain network. After collecting all the block generated in the previous step, the consortium node votes send a total voting message (the hash value of each block, as well as the agreed opinion and signature) to the leader node. The leader node counts the voting results and random selects the next leader node, which publishes the block group header to the consortium blockchain network. When a blockchain node receives the block generated by the bookkeeping nodes and the block group header generated by the leader node, it will store them in the database as a block group.

Abstract: A method comprising: A. forming a consortium blockchain network using domain network nodes and selecting committee members from top-level domain nodes; B. the committee member who received most votes packs the genesis block and generates a random number; C. the housekeeper having the same number as the random number packs the current block and generates a random number for selecting a next housekeeper to pack the next block, each block is approved by more than half of the committee members; D. during the duty cycle, each housekeeper takes turns packing blocks and generating random numbers and the process is repeated. If a block is not approved, the housekeeper with the next number is requested to repack the block; and E. the last random number generated by a housekeeper before the duty cycle ends is used to select the housekeeper to pack the first block of the next duty cycle.