Patents by Inventor Kakuhei Isawa
Kakuhei Isawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210282421Abstract: A method for producing liquid fermented milk according to the present invention includes: preparing a fermented milk base that contains milk protein containing whey protein; adding a lactic acid bacteria starter to the fermented milk base and then inducing fermentation to produce fermented milk curds; breaking the fermented milk curds to produce fermented milk having an average particle diameter of 1 ?m or more and 20 ?m or less; and holding the fermented milk in a container to thicken the fermented milk, thereby producing liquid fermented milk, the liquid fermented milk containing the milk protein in an amount of 2.5% or more, the milk protein containing the whey protein in an amount of 25% or more, the liquid fermented milk having a viscosity at 10° C. of 100 mPa·s or more and 700 mPa·s or less.Type: ApplicationFiled: July 30, 2019Publication date: September 16, 2021Applicant: MEIJI CO., LTD.Inventors: Yoshitaka KAWAI, Kakuhei ISAWA, Tomomi ABE
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Patent number: 8709516Abstract: A method for culturing lactic acid bacteria includes (a) adding a proteolytic enzyme to an aqueous whey solution containing whey and water to thereby prepare a culture solution containing whey degraded by the proteolytic enzyme; (b) inoculating the culture solution with Lactobacillus gasseri which is a bacteriocin-producing lactic acid bacteria; and (c) maintaining the culture solution inoculated with the bacteriocin-producing lactic acid bacteria at a pH of not lower than 5.2 and not higher than 5.8 to provide cultured lactic acid bacteria. After the completion of culturing, the culture solution is centrifuged to separate a concentrated cell suspension containing the lactic acid bacterium in a concentrated form. The concentrated cell suspension has extremely high antibacterial activity, several tens of thousands AU, and is usable as a food preservative. Yogurt is produced by fermenting a yogurt mix to which 0.01% to 0.1% by weight of the concentrated cell suspension is added.Type: GrantFiled: March 26, 2010Date of Patent: April 29, 2014Assignee: Meiji Co., Ltd.Inventors: Kakuhei Isawa, Masayuki Kamijo
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Patent number: 8465933Abstract: Lactobacillus screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli compatible with ABO blood groups can be screened by setting 100 RU as a criterion for judging bacterial binding under certain conditions. Using 238 lactobacillus strains, the above-mentioned screening methods and tests to judge their compatibility for the use of yogurt production were carried out, to at long last specifically discover bacillus strains compatible with blood groups A, B, and O.Type: GrantFiled: January 10, 2011Date of Patent: June 18, 2013Assignee: Meiji Co., LtdInventors: Tadao Saito, Yasushi Kawai, Hideaki Uchida, Katsunori Kimura, Kakuhei Isawa, Keisuke Furuichi
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Patent number: 8277860Abstract: A method for stabilizing 1,4-dihydroxy-2-naphthoic acid, which comprises reducing an oxygen dissolved in a solution containing 1,4-dihydroxy-2-naphthoic acid, and food or drink containing 1,4-dihydroxy-2-naphthoic acid.Type: GrantFiled: March 26, 2004Date of Patent: October 2, 2012Assignee: Meiji Co., Ltd.Inventors: Kakuhei Isawa, Tadashi Nakatsubo, Satoshi Hayashi, Yasushi Kubota
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Patent number: 8110607Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: GrantFiled: September 8, 2010Date of Patent: February 7, 2012Assignee: Meiji Co., Ltd.Inventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Publication number: 20120027888Abstract: Protein in an aqueous whey solution is degraded by adding a protease to the aqueous whey solution. After that, a whey degradation medium is prepared by adding yeast extract or the like to the aqueous whey solution. The whey degradation medium is inoculated with bacteriocin-producing lactic acid bacterium and the lactic acid bacterium is cultured while the whey degradation medium is maintained at pH of not lower than 5 and not higher than 6. After the completion of the culture, the whey degradation medium (culture solution) is centrifuged to thereby separate a concentrated cell suspension containing the lactic acid bacterium in a concentrated form. The concentrated cell suspension has extremely high antibacterial activity (several tens of thousands AU) and is usable as a food preservative. Further, yogurt is produced by fermenting a yogurt mix to which 0.01% to 0.1% by weight of the concentrated cell suspension is added. With this process, it is possible to suppress an increase in the acidity of the yogurt.Type: ApplicationFiled: March 26, 2010Publication date: February 2, 2012Applicant: Meji Co. LtdInventor: Kakuhei Isawa
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Publication number: 20110104721Abstract: Lactobacillus screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli compatible with ABO blood groups can be screened by setting 100 RU as a criterion for judging bacterial binding under certain conditions. Using 238 lactobacillus strains, the above-mentioned screening methods and tests to judge their compatibility for the use of yogurt production were carried out, to at long last specifically discover bacillus strains compatible with blood groups A, B, and O.Type: ApplicationFiled: January 10, 2011Publication date: May 5, 2011Inventors: Tadao Saito, Yasushi Kawai, Hideaki Uchida, Katsunori Kimura, Kakuhei Isawa, Keisuke Furuichi
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Patent number: 7897374Abstract: Lactobacillus screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli compatible with ABO blood groups can be screened by setting 100 RU as a criterion for judging bacterial binding under certain conditions. Using 238 lactobacillus strains, the above-mentioned screening methods and tests to judge their compatibility for the use of yogurt production were carried out, to at long last specifically discover bacillus strains compatible with blood groups A, B, and O.Type: GrantFiled: December 1, 2005Date of Patent: March 1, 2011Assignee: Meiji Dairires CorporationInventors: Tadao Saito, Yasushi Kawai, Hideaki Uchida, Katsunori Kimura, Kakuhei Isawa, Keisuke Furuichi
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Publication number: 20110009491Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: ApplicationFiled: September 8, 2010Publication date: January 13, 2011Applicant: MEIJI DAIRIES CORPORATIONInventors: Yoshio SATO, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Patent number: 7834061Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: GrantFiled: August 19, 2009Date of Patent: November 16, 2010Assignee: Meiji Dairies CorporationInventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Publication number: 20100247500Abstract: The survival of lactic acid bacterial strains such as probiotic bacteria contained in yogurt etc. is improved. A lactic acid bacterium survival improver including a propionic acid bacterium fermentation product to improve the survival of a lactic acid bacterium. The propionic acid bacterium is a bacterium belonging to the genus Propionibacterium. The bacterium belonging to the genus Propionibacterium is Propionibacterium freudenreichii.Type: ApplicationFiled: November 18, 2008Publication date: September 30, 2010Inventors: Kakuhei Isawa, Hideaki Uchida, Keisuke Furuichi, Fuyuko Yamamoto
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Publication number: 20100015110Abstract: The present invention provides a composition and fermented milk, which is derived from natural product, is highly safe, exhibits improvement effect and/or therapeutic effect on skin, and comprises fermented lactic acid bacteria excellent in manufacturability. Disclosed are: use of Streptococcus thermophilus OLS3059 in skin improvement and/or treatment; a composition for skin improvement and/or treatment comprising Streptococcus thermophilus OLS3059 and/or a culture thereof; food and drink comprising the composition; fermented milk for skin improvement and/or treatment prepared by using Lactobacillus delbrueckii subspecies bulgaricus and Streptococcus thermophilus OLS3059; and the fermented milk for skin improvement and/or treatment further comprising collagen peptide and/or ceramide.Type: ApplicationFiled: December 26, 2006Publication date: January 21, 2010Applicant: Meiji Dairies CorporationInventors: Hiroshi Kano, Teruyuki Noma, Shuji Ikegami, Hiroyuki Ito, Kakuhei Isawa
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Publication number: 20090312425Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: ApplicationFiled: August 19, 2009Publication date: December 17, 2009Applicant: MEIJI DAIRIES CORPORATIONInventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Patent number: 7629155Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: GrantFiled: April 9, 2008Date of Patent: December 8, 2009Assignee: Meiji Dairies CorporationInventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Publication number: 20080194688Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: ApplicationFiled: April 9, 2008Publication date: August 14, 2008Applicant: MEIJI DAIRIES CORPORATIONInventors: Yoshio SATO, Seiya MAKINO, Nobuo YODA, Kakuhei ISAWA, Tomonori KAMIYAMA, Kenichi HOJO, Mizue SAITO, Naoki TAKETOMO, Keisuke FURUICHI, Shuji IKEGAMI
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Publication number: 20080160565Abstract: Lactobacillus screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli compatible with ABO blood groups can be screened by setting 100 RU as a criterion for judging bacterial binding under certain conditions. Using 238 lactobacillus strains, the above-mentioned screening methods and tests to judge their compatibility for the use of yogurt production were carried out, to at long last specifically discover bacillus strains compatible with blood groups A, B, and O.Type: ApplicationFiled: December 1, 2005Publication date: July 3, 2008Applicant: MEIJI DAIRIES CORPORATIONInventors: Tadao Saito, Yasushi Kawai, Hideaki Uchida, Katsunori Kimura, Kakuhei Isawa, Keisuke Furuichi
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Patent number: 7374915Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: GrantFiled: August 6, 2002Date of Patent: May 20, 2008Assignee: Meiji Dairies CorporationInventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Publication number: 20060287553Abstract: A method for stabilizing 1,4-dihydroxy-2-naphthoic acid, which comprises reducing an oxygen dissolved in a solution containing 1,4-dihydroxy-2-naphthoic acid, and food or drink containing 1,4-dihydroxy-2-naphthoic acid.Type: ApplicationFiled: March 26, 2004Publication date: December 21, 2006Inventors: Kakuhei Isawa, Tadashi Nakatsubo, Satoshi Hayashi, Yasushi Kubota
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Publication number: 20040241815Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: ApplicationFiled: July 13, 2004Publication date: December 2, 2004Inventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Patent number: 5929109Abstract: The present invention relates to an agent for enhancing and stabilizing the activity of Bifidus factor, containing at least one member selected from the group consisting of ascorbic acid, hyposulfurous acid and acetic anhydride as the effective ingredient, and by preparing the agent singly or in combination with Bifidus factor as a food and drink type or as a composition of pharmaceutical type, intestinal microflora can be ameliorated. The agent can be used as a selective medium for assaying the number of bifidobacteria.Type: GrantFiled: October 3, 1997Date of Patent: July 27, 1999Assignee: Meiji Milk Products Company LimitedInventors: Hiroharu Mori, Kakuhei Isawa, Tsutomu Kaneko