Patents by Inventor Kakushima Matsushita

Kakushima Matsushita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic Medicine Containing Monoclonal Antibody Against Folate Receptor Beta (Fr-Beta)
    Publication number: 20080260812
    Abstract: An objective of the present invention is to provide a therapeutic agent for treating rheumatoid arthritis, juvenile rheumatoid arthritis, macrophage activation syndrome, septicemia, and FR-? expressing leukemia, which induces apoptosis in activated macrophages and folate receptor beta (FR-?) expressing leukemia cells to specifically destroy these cells. An FR-? monoclonal antibody of the present invention is preferably an IgG-type monoclonal antibody which specifically reacts with a human-type FR-? antigen and is produced from a clone resulting from immunization with an FR-? expressing B300-19 cell. The FR-? monoclonal antibody of the present invention specifically reacts with the FR-? antigen of activated macrophages and FR-? expressing leukemia cells and a therapeutic agent of the present invention contains an FR-? antibody immunotoxin which causes apoptosis in activated macrophages and FR-? expressing leukemia cells, as an active ingredient.
    Type: Application
    Filed: April 25, 2005
    Publication date: October 23, 2008
    Applicants: Takami Matsuyama c/o Kagoshima University, Innovatis Pharma Corporation
    Inventors: Takami Matsuyama, Ryusaku Nagayoshi, Yasuhiro Tsuneyoshi, Taku Nagai, Kakushima Matsushita