Patents by Inventor Kalakota Reddy

Kalakota Reddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphoramidite activator for oligonucleotide synthesis
    Publication number: 20060178509
    Abstract: The present invention provides an improved phosphoramidite activator comprising a solution of 5-benzylmercaptotetrazole in acetonitrile and N-alkyimidazole. Further provided are improved methods of oligonucleotide synthesis wherein a phosphoramidite activator comprising a solution of 5-benzylmercaptotetrazole in acetonitrile and N-alkyimidazole is used to prepare internucleoside linkages.
    Type: Application
    Filed: February 8, 2005
    Publication date: August 10, 2006
    Inventor: Kalakota Reddy
  • Methods of producing phosphitylated compounds
    Publication number: 20050124804
    Abstract: Provided are methods of producing phosphitylated compounds, including 3?-O-phosphoramidites, comprising the step of reacting a hydroxyl-containing compound with a phosphitylating agent in the presence of a phosphitylation activator selected from the group consisting of: (1) acid-base complexes derived from an amine base of Formula II wherein R3, R4, R5, R6, and R7 are independently hydrogen, C1-C10 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, C7-C10 aralkyl, C1-C10 heteroalkyl, or C1-C10 heteroaryl, and at least one of R3, R4, R5, R6, and R7 is not hydrogen; (2) zwitterionic amine complexes; and (3) combinations of two or more thereof, to produce a phosphitylated compound.
    Type: Application
    Filed: November 16, 2004
    Publication date: June 9, 2005
    Inventors: Christian Werner, Frank Nerenz, Andreas Kanschik-Conradsen, Kalakota Reddy
  • Methods of producing phosphitylated compounds
    Patent number: 6894158
    Abstract: Provided are methods of producing phosphitylated compounds, including 3?-O-phosphoramidites, comprising the step of reacting a hydroxyl-containing compound with a phosphitylating agent in the presence of a phosphitylation activator selected from the group consisting of: (1) acid-base complexes derived from an amine base of Formula I wherein R, R1, and R2 are independently C1-C10 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, C7-C10 aralkyl, C1-C10 heteroalkyl, or C1-C10 heteroaryl, wherein any two adjacent R, R1, and R2 may be connected to form a heterocyclic ring; (2) acid-base complexes derived from a diazabicyclo amine base; and (3) combinations of two or more thereof.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: May 17, 2005
    Assignee: Honeywell International Inc.
    Inventors: Christian Werner, Frank Nerenz, Andreas Kanschik-Conradsen, Kalakota Reddy
  • Methods of producing phosphitylated compounds
    Publication number: 20030232980
    Abstract: Provided are methods of producing phosphitylated compounds, including 3′-O-phosphoramidites, comprising the step of reacting a hydroxyl-containing compound with a phosphitylating agent in the presence of a phosphitylation activator selected from the group consisting of: (1) acid-base complexes derived from an amine base of Formula I 1
    Type: Application
    Filed: February 24, 2003
    Publication date: December 18, 2003
    Inventors: Christian Werner, Frank Nerenz, Andreas Kanschik-Conradsen, Kalakota Reddy