Patents by Inventor Kalkunte S. Srivenugopal

Kalkunte S. Srivenugopal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HNQO1-activatable fluorescent probe for imaging cancer cells in-vitro and in-vivo
    Patent number: 11957766
    Abstract: The present invention includes a probe, an assay, a method of detecting, a human NAD(P)H quinone oxidoreductase-1 (hNQO1) enzyme activity with a fluorescent probe comprising a quinone propionic acid (QPA) conjugated to dicyanoisophorone (DCP), wherein the hNQO1 reduces the probe to releases a fluorescent DCP, and a method of making the same.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: April 16, 2024
    Assignee: TEXAS TECH UNIVERSITY SYSTEM
    Inventors: Kalkunte S. Srivenugopal, Surendra R. Punganuru
  • DISULFIRAM AND OTHER REDOX-RELATED COMPOSITIONS FOR BRAIN TUMORS
    Publication number: 20230045112
    Abstract: The present disclosure provides a compositions and methods of inhibiting O6-methylguanine DNA methyltransferase in human tumor cells by providing an effective amount of an agent that directly or indirectly inhibits the O6-methylguanine DNA methyltransferase in a pharmaceutically acceptable carrier, wherein the amount is effective to potentiate an anti-tumor activity of one or more alkylating agents, platinum drugs, or antimetabolites, wherein tumor cells are triggered into programmed cell death.
    Type: Application
    Filed: September 29, 2022
    Publication date: February 9, 2023
    Inventors: Kalkunte S. Srivenugopal, Ameya M. Paranjpe
  • HNQO1-ACTIVATABLE FLUORESCENT PROBE FOR IMAGING CANCER CELLS IN-VITRO AND IN-VIVO
    Publication number: 20210154330
    Abstract: The present invention includes a probe, an assay, a method of detecting, a human NAD(P)H quinone oxidoreductase-1 (hNQO1) enzyme activity with a fluorescent probe comprising a quinone propionic acid (QPA) conjugated to dicyanoisophorone (DCP), wherein the hNQO1 reduces the probe to releases a fluorescent DCP, and a method of making the same.
    Type: Application
    Filed: November 17, 2020
    Publication date: May 27, 2021
    Inventors: Kalkunte S. Srivenugopal, Surendra R. Punganuru
  • Disulfiram Compositions and Treatments for Brain Tumors
    Publication number: 20160346231
    Abstract: The present disclosure provides a compositions and methods of inhibiting 06-methylguanine DNA methyltransferase in human tumor cells by providing an effective amount of a disulfiram composition to inhibit the 06-methylguanine DNA methyltransferase in a pharmaceutically acceptable carrier to inhibit 06-methylguanine DNA methyltransferase.
    Type: Application
    Filed: February 6, 2015
    Publication date: December 1, 2016
    Inventors: Kalkunte S. Srivenugopal, Ameya M. Paranjpe