Abstract: The present invention provides an improved breath analyzer and breath test method to determine the presence or absence of disease in humans, including but not limited to, the bacterium H. Pylori in a subject's digestive tract.

Abstract: Disclosed herein is a multi-modal imaging methodology for creating patient-specific three-dimensional images of a breast volume, for use in the production of breast implants. In one aspect, a surface imaging technique may be used to create a three-dimensional model of an external shape of a patient, such as the external morphology of a breast. In one aspect, an internal imaging technique may be used to create a three-dimensional model of the internal shape of the thorax underneath the breast. The external and internal models may then be referenced to one another and a unified model may be created to generate a reliable, personalized model of breast volume.

Abstract: The present invention provides an improved breath analyzer and breath test method to determine the presence of a gastrointestinal disorder in a human subject's digestive tract.

Abstract: Disclosed is device for in vivo monitoring to detect infection associated with a prosthetically implanted device, such as a prosthetic knee. The device includes a sensor to detect the presence of one or more proteins secreted by body tissues in response to infection. The sensor may include a surface with a molecular imprint of the protein connected with a potentiometric or amperometic measuring device to detect when the protein bonds with the implanted surface. The device further includes an inductive coil coupled with a corresponding coil located outside the body. Electrical power for operating the measuring device and other circuitry is provided by inductive coupling between the coils. Signals indicating whether the protein is detected are communicated from the device to the external circuitry connected with the external coil.

Abstract: A device detects infection associated with a prosthetically implanted device, such as a prosthetic knee. The device includes a sensor to detect the presence of one or more proteins secreted by body tissues in response to infection. The sensor may include a surface with a molecular imprint of the protein connected with a potentiometric or amperometric measuring device to detect when the protein bonds with the implanted surface. The device further includes an inductive coil coupled with a corresponding coil located outside the body. Electrical power for operating the measuring device and other circuitry is provided by inductive coupling between the coils. Signals indicating whether the protein is detected are communicated from the device to the external circuitry connected with the external coil.

Abstract: Provided methods of detecting physiological states and/or disease states of an individual. Also provided are systems for detecting physiological states and/or disease states of an individual. The method are based on the response of organic semiconducting materials to one or more components of a biogas sample from an individual.

Abstract: Apparatus for producing a three dimensional nanofiber structure includes (1) at least two spaced electrodes; (2) a spinner adapted to rotate the at least two spaced electrodes; (3) a syringe assembly adapted to eject a polymer solution from a syringe of the syringe assembly towards the at least two spaced electrodes while the at least two spaced electrodes are rotated by the spinner; and (4) a power supply assembly for providing the two spaced electrodes at a first electric potential, and for providing the syringe at a second electric potential which is different from the first electric potential. A composition of matter may include (1) a least one layer of nanofibers in which a distribution of angles of fibers is “aligned;” and (2) at least one gel layer, wherein the at least one layer of microfibers and the at least one gel layer alternate to form a laminate.

Abstract: Disclosed is device for in vivo monitoring to detect infection associated with a prosthetically implanted device, such as a prosthetic knee. The device includes a sensor to detect the presence of one or more proteins secreted by body tissues in response to infection. The sensor may include a surface with a molecular imprint of the protein connected with a potentiometric or amperometric measuring device to detect when the protein bonds with the implanted surface. The device further includes an inductive coil coupled with a corresponding coil located outside the body. Electrical power for operating the measuring device and other circuitry is provided by inductive coupling between the coils. Signals indicating whether the protein is detected are communicated from the device to the external circuitry connected with the external coil.

Abstract: Fabrication of a high sensitivity potentiometric biosensor is described. The present inventors have developed and characterized a novel amplification platform using a gold nanoparticle (GNPs) electrodeposition method. The synthesized GNP sizes were found to be dependent of HAuCl4 concentration, media acid, scan cycles and scan rate. A systematic investigation into the adsorption of different sizes of proteins from aqueous electrolyte solution onto the electrodeposited GNPs surface by the potentiometric method was performed. Results suggest that the size of different proteins affect how they bond to different sizes of GNPs. This GNPs-based biosensor can retain the native-like structure of proteins, and successfully detect proteins at a high sensitivity level. The resulting glucose and immune biosensors also exhibit low detection limit and wide linear range.

Abstract: Specific ionic interactions with a sensing material that is electrically coupled with the floating gate of a floating gate-based ion sensitive field effect transistor (FGISFET) may be used to sense a target material. For example, an FGISFET can use (e.g., previously demonstrated) ionic interaction-based sensing techniques with the floating gate of floating gate field effect transistors. The floating gate can serves as a probe and an interface to convert chemical and/or biological signals to electrical signals, which can be measured by monitoring the change in the device's threshold voltage, VT.

Abstract: Apparatus for producing a three dimensional nanofiber structure includes (1) at least two spaced electrodes; (2) a spinner adapted to rotate the at least two spaced electrodes; (3) a syringe assembly adapted to eject a polymer solution from a syringe of the syringe assembly towards the at least two spaced electrodes while the at least two spaced electrodes are rotated by the spinner; and (4) a power supply assembly for providing the two spaced electrodes at a first electric potential, and for providing the syringe at a second electric potential which is different from the first electric potential. A composition of matter may include (1) a least one layer of nanofibers in which a distribution of angles of fibers is “aligned;” and (2) at least one gel layer, wherein the at least one layer of microfibers and the at least one gel layer alternate to form a laminate.

Abstract: Fabrication of a high sensitivity potentiometric biosensor is described. The present inventors have developed and characterized a novel amplification platform using a gold nanoparticle (GNPs) electrodeposition method. The synthesized GNP sizes were found to be dependent of HAuCl4 concentration, media acid, scan cycles and scan rate. A systematic investigation into the adsorption of different sizes of proteins from aqueous electrolyte solution onto the electrodeposited GNPs surface by the potentiometric method was performed. Results suggest that the size of different proteins affect how they bond to different sizes of GNPs. This GNPs-based biosensor can retain the native-like structure of proteins, and successfully detect proteins at a high sensitivity level. The resulting glucose and immune biosensors also exhibit low detection limit and wide linear range.

Abstract: Sensors suitable for the sensing/detection of biological or chemical agents may be fabricated by immobilizing biological and/or chemical recognition components (selectors or probes) on a substrate by the polymerization of a suitable monomer in the presence of the selectors or probes, for example, by Polysiloxane Monolayer Immobilization (PMI). PMI may involve the polymerization of polysiloxane onto a substrate, onto which selector molecules are adsorbed or otherwise immobilized. The resulting immobilized selector molecule may then be used to interact with specific molecules (targets) within a mixture of molecules, thereby enabling those specific molecules to be detected and/or quantified.

Abstract: Sensors suitable for the sensing/detection of biological or chemical agents may be fabricated by immobilizing biological and/or chemical recognition components (selectors or probes) on a substrate by the polymerization of a suitable monomer in the presence of the selectors or probes, for example, by Polysiloxane Monolayer Immobilization (PMI). PMI may involve the polymerization of polysiloxane onto a substrate, onto which selector molecules are adsorbed or otherwise immobilized. The resulting immobilized selector molecule may then be used to interact with specific molecules (targets) within a mixture of molecules, thereby enabling those specific molecules to be detected and/or quantified.

Abstract: The invention concerns a method for controlling the adhesive bond between an electric-field responsive material and a substrate, which method comprises using an electric field to control the strength and integrity of the adhesive bond. The method may be used, for example, for removing or delaminating a material, which material is responsive to an electric field, from a substrate. The invention further comprises elimination of the application of the electric field and application of the previously removed electric-field-responsive material to the substrate, thereby resuming the strength and integrity of the adhesive bond. The invention includes apparatus for use in the bond controlling process.

Abstract: An electrochemical method for producing a hole extraction layer in a solar cell based on organic semiconductor materials. Conjugated polymers are used to build a hole extraction layer and a photoactive layer. Poly(3,4-ethylenedioxythiophene) (PEDOT) is used as a hole extraction layer and is deposited electrochemically from an aqueous solution on an indium tin oxide (ITO) electrode. A nanofibrilar or nanogranular morphology of the PEDOT is achieved by carrying out the polymerization in the presence of a surfactant. A photoactive layer of poly(3-hexylthiophene)/[6,6]-phenyl-C61-butyric acid methyl ester (P3HT/PCBM) can be deposited by spin-coating technique on top of the PEDOT layer.

Abstract: The invention concerns a method for controlling the adhesive bond between an electric-field responsive material and a substrate, which method comprises using an electric field to control the strength and integrity of the adhesive bond. The method may be used, for example, for removing or delaminating a material, which material is responsive to an electric field, from a substrate. The invention further comprises elimination of the application of the electric field and application of the previously removed electric-field-responsive material to the substrate, thereby resuming the strength and integrity of the adhesive bond. The invention includes apparatus for use in the bond controlling process.

Abstract: An electrochemical method for producing a hole extraction layer in a solar cell based on organic semiconductor materials. Conjugated polymers are used to build a hole extraction layer and a photoactive layer. Poly(3,4-ethylenedioxythiophene) (PEDOT) is used as a hole extraction layer and is deposited electrochemically from an aqueous solution on an indium tin oxide (ITO) electrode. A nanofibrilar or nanogranular morphology of the PEDOT is achieved by carrying out the polymerization in the presence of a surfactant. A photoactive layer of poly(3-hexylthiophene)/[6,6]-phenyl-C61-butyric acid methyl ester (P3HT/PCBM) can be deposited by spin-coating technique on top of the PEDOT layer.

Abstract: A real-time method employing a portable peptide-containing potentiometric biosensor, can directly detect and/or quantify bacterial spores. Two peptides for specific recognition of B. subtilis and B. anthracis Sterne may be immobilized by a polysiloxane monolayer immobilization (PMI) technique. The sensors translate the biological recognition event into a potential change by detecting, for example, B. subtilis spores in a concentration range of 0.08-7.3×104 CFU/ml. The sensing method exhibited highly selective recognition properties towards Bacillus subtilis spores over other kinds of spores. The selectivity coefficients of the sensors for other kinds of spores are in the range of 0-1.0×10?5. The biosensor method not only has the specificity to distinguish Bacillus subtilis spores in a mixture of B. subtilis and B. thuringiensis (thur.) Kurstaki spores, but also can discriminate between live and dead B. subtilis spores. Furthermore, the sensing method can distinguish a Bacillus subtilis 1A700 from other B.

Abstract: An electrospinning apparatus for spinning polymer fibers from a fluid delivered by a jet supply device, which apparatus comprises at least one collector of a plurality of collectors in electrical communication with an electrode of the jet supply device. Collectors are insulated from each other. At least one collector comprises a stretcher adapted to stretch polymer fibers. The stretcher is an integral part of at least one collector. A controller controls sequence and time duration at which collectors are in electrical communication with the electrode of the jet supply device creating a non-woven polymer fabric or weaving polymer fibers into a fabric. The electrospinning apparatus comprises a rotator adapted to rotate the stretcher.