Patents by Inventor Kalman Hideg
Kalman Hideg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8722707Abstract: Compositions and methods for treating post angioplasty restenosis, arteriosclerosis, and/or smooth muscle cell proliferation and/or neointimal hyperplasia in vascular tissues, and at least one composition of a redox based curcumin derivative, DAP-F(p) and a pharmaceutically acceptable carrier, are described.Type: GrantFiled: July 6, 2010Date of Patent: May 13, 2014Assignee: The Ohio State UniversityInventors: Periannan Kuppusamy, Kalman Hideg, Karuppaiyah Selvendiran
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Publication number: 20120316203Abstract: Methods and compositions for treating cancers, including ovarian cancers, are described. The compositions generally include a redox based curcumin derivative, diarylidenylpiperiden-4-one (DAP) having a hydroxylamine moiety attached thereto.Type: ApplicationFiled: July 6, 2010Publication date: December 13, 2012Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Periannan Kuppusamy, Kalman Hideg
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Patent number: 7994182Abstract: The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula (I), that inhibit a DNA-repairing enzyme, poly(ADP-ribose) polymerase (PARP), enabling them to be used for the preparation of pharmaceutical compositions for preventing or treating illnesses where PARP-inhibition yields a beneficial effect. In general formula (I) R1 stands for either hydrogen or a group of general formula (a); R2 stands for a) hydrogen or C1-6 alkyl group, if R1 is other than hydrogen, and b) if R1 is hydrogen, then R2 may be a group of general formula (b), (c) or (d). The subject of the present invention also embraces the preparation processes of the compounds described above.Type: GrantFiled: April 30, 2004Date of Patent: August 9, 2011Assignee: Pecsi TudomanyegyetemInventors: Balázs Sümegi, Kálmán Hideg, Tamás Kálai
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Publication number: 20070072912Abstract: Compounds of the formula (I) and their pharmaceutically acceptable or technically applicable acid salts—where in the formula R1 represents hydrogen, C(1-4)alkyl or C(1-4)alkoxy R2 represents hydrogen, C(1-4)alkyl, carboxyl, C(1-4)alkoxycarbonyl, carboxamido, aryl or hetero-aryl R3 represents hydrogen, C(1-4)alkyl, aryl-methylene, or aryl, Y is a valency bond, a straight or branched chain C(1-4)alkene, a carbonyl-amino-C(1-4)alkene, or a —S—(CH2)m— group, where all alkene groups above may be spaced by an arylene group, n represents zero or the integer 1 m represents the integer 1, 2 or 3 Q represents hydrogen, hydroxyl or the oxygen radical (0) or together with the N atom of the adjacent ring forms a +N=O (oxoimmonium) group Z represents a single or double bond and their pharmaceutically acceptable or technically useful salts, processes for their preparation and their biological use as PARP inhibitors and antioxidants.Type: ApplicationFiled: April 27, 2004Publication date: March 29, 2007Applicant: Cedars-Sinai Medical CenterInventors: Kalman Hideg, Tamas Kalai, Balazs Sumegi
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Publication number: 20070042935Abstract: The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula (I), that inhibit a DNA-repairing enzyme, poly(ADP-ribose) polymerase (PARP), enabling them to be used for the preparation of pharmaceutical compositions for preventing or treating illnesses where PARP-inhibition yields a beneficial effect. In general formula (I) R1 stands for either hydrogen or a group of general formula (a); R2 stands for a) hydrogen or C1-6 alkyl group, if R1 is other than hydrogen, and b) if R1 is hydrogen, then R2 may be a group of general formula (b), (c) or (d). The subject of the present invention also embraces the preparation processes of the compounds described above.Type: ApplicationFiled: April 30, 2004Publication date: February 22, 2007Inventors: Balazs Sumegi, Kalman Hideg, Tamas Kalai
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Patent number: 5032600Abstract: The invention refers to new diamines of the Formula I ##STR1## wherein R stands for ##STR2## or --NH--COA.sup.1 --R.sup.4 or ##STR3## wherein A stands for C.sub.1-5 alkylene which can be substituted by hydroxyl,X stands for a single or double bond,R.sup.2 stands for aryl or heteroaryl optionally substituted by halogen, C.sub.1-4 alkoxy or acylamino,R.sup.3 stands for hydrogen or C.sub.1-4 alkyl,A.sup.1 stands for a single bond or C.sub.1-5 alkyl optionally substituted by hydroxyl or thioalkylene or oxyalkylene,R.sup.4 stands for a 5- or 6- membered aromatic or heteroaromatic ring which can be substituted by one or more hydroxyl, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy and/or halogen or methylenedioxy and the alkyl group can be unsaturated as well,Q stands for a 6-membered ring which can be partially hydrogenated, andR.sup.1 stands for C.sub.1-4 alkyl.The new compounds are antiarrhythmic agents.Type: GrantFiled: October 31, 1990Date of Patent: July 16, 1991Assignee: Alkaloida Vegyeszeti GyarInventors: Kalman Hideg, Olga H. Hankovszky, Laszlo Frank, Ilona Bodi, Jozsef Csak
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Patent number: 5028609Abstract: The invention refers to new diamines of the Formula I ##STR1## wherein R stands for ##STR2## wherein A stands for C.sub.1-5 alkylene which can be substituted by hydroxyl,X stands for a single or double bond,R.sup.2 stands for aryl or heteroaryl optionally substituted by halogen, C.sub.1-4 alkoxy or acylamino,R.sup.3 stands for hydrogen or C.sub.1-4 alkyl,A.sup.1 stands for a single bond or C.sub.1-5 alkyl optionally substituted by hydroxyl or thioalkylene or oxyalkylene,R.sup.4 stands for a 5- or 6- membered aromatic or heteroaromatic ring which can be substituted by one or more hydroxyl, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy and/or halogen or methylenedioxy and the alkyl group can be unsaturated as well,Q stands for a 6-membered ring which can be partially hydrogenated, andR.sup.1 stands for C.sub.1-4 alkyl.The new compounds are antiarrhythmic agents.Type: GrantFiled: November 27, 1989Date of Patent: July 2, 1991Assignee: Alkaloida Vegyeszeti GyarInventors: Kalman Hideg, Olga H. Hankovszky, Laszlo Frank, Ilona Bodi, Jozsef Csak
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Patent number: 4897413Abstract: The invention refers to new diamines of the Formula I ##STR1## wherein stands for ##STR2## wherein A stands for C.sub.1-5 alkylene which can be substituted by hydroxyl,X stands for a single or double bond,R.sup.2 stands for aryl or heteroaryl optionally substituted by halogen, C.sub.1-4 alkoxy or acylamino,R.sup.3 stands for hydrogen or C.sub.1-4 alkyl,A.sup.1 stands for a single bond or C.sub.1-5 alkyl optionally substituted by hydroxyl or thioalkylene or oxyalkylene,R.sup.4 stands for a 5- or 6- membered aromatic or heteroaromatic ring which can be substituted by one or more hydroxyl, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy and/or halogen or methylenedioxy and the alkyl group can be unsaturated as well,Q stands for a 6-membered ring which can be partially hydrogenated, andR.sup.1 stands for C.sub.1-4 alkyl.The new compounds are antiarrhythmic agents.Type: GrantFiled: October 16, 1987Date of Patent: January 30, 1990Assignee: Alkaloida Vegyeszeti GyarInventors: Kalman Hideg, Olga H. Hankovszky, Laszlo Frank, Ilona Bodi, Jozsef Csak
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Patent number: 4731376Abstract: Compounds are disclosed of the formula (I) ##STR1## wherein A.sup.1 is a valence bond or a C.sub.1 to C.sub.5 straight or branched chain alkylene group unsubstituted or substituted by hydroxy or aminocarbonyl;B is a valence bond or a double bond;R.sup.3 is hydrogen or C.sub.1 to C.sub.4 alkyl;R.sup.2 is a phenyl or phenoxy group unsubstituted or substituted by one or two C.sub.1 to C.sub.4 alkyl groups, C.sub.1 to C.sub.4 alkoxy groups, or halo substituents; or R.sup.2 is an amino group, a diphenylmethyl group, or an R.sup.4 --NH--CO-- group in whichR.sup.4 is 2,6-dimethyl-phenyl; or a pharmaceutically acceptable acid addition salt thereof. The compounds possess anti-arrhythmic activity and exert little or no hypotensive side effects.Type: GrantFiled: August 14, 1986Date of Patent: March 15, 1988Assignee: Alkaloida Vegyeszeti GyarInventors: Kalman Hideg, Olga H. Hankovszky, Laszlo Frank, Ilona Bodi, Jozsef Csak
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Patent number: 4703056Abstract: The invention relates to new anti-arrhythmic compounds of the formula (I) ##STR1## wherein A is C1 to C5 alkylene which can be substituted by hydroxyl;X is a single or a double bond; andQ is a 6-membered carbocyclic moiety fused to each of the adjacent carbonyl carbon atoms, and which is either fully hydrogenated, partially hydrogenated, or aromatic, or a pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: September 20, 1984Date of Patent: October 27, 1987Assignee: Alkaloida Vegyeszeti GyarInventors: Kalman Hideg, Olga H. Hankovszky, Laszlo Frank, Ilona Bodi, Jozsef Csak
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Patent number: 4017507Abstract: New tricyclic fused imidazole derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for hydrogen or hydroxy,n is equal to zero or one,m is equal to zero, one or two,A stands for a group of the general formula (II), ##STR2## wherein R.sub.2 represents hydrogen or hydroxy,R.sub.3 represents hydrogen or amino, orQ and Z each stand for nitrogen or a=C-- group, orA stands for a group of the general formula (III), ##STR3## wherein R.sub.4 and R.sub.5 each represent hydrogen, methyl, chlorine or nitro,Were prepared by reacting a compound of the general formula (IV) ##STR4## wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), ##STR5## wherein X stands for halogen, R.sub.6 stands for hydrogen and R.sub.7 stands for a group of the general formula (VI),--(ch.sub.2).sub.m --X VI.in which m and X each have the same meanings as defined above, or R.sub.6 and R.sub.7 together stand for oxygen.Type: GrantFiled: December 5, 1975Date of Patent: April 12, 1977Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Kalman Hideg, Olga Hankovszky, Eva Palosi, Gyorgy Hajos, Laszlo Szporny
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Patent number: 3941788Abstract: New benzimidazole derivatives of the general formula (I) ##SPC1##and acid addition salts thereof, whereinR.sub.1 and R.sub.2 each represent hydrogen or methyl,R.sub.5 and R.sub.6 form together a valence bond and at the same time R.sub.3 and R.sub.4 form together a group of the general formula (II), ##EQU1## wherein n is equal to zero or one, or R.sub.4, R.sub.5 and R.sub.6 form together a group of the formula (III) ##EQU2## and at the same time R.sub.3 stands for benzyl group, were prepared by reacting a compound of the general formula (IV), ##SPC2##wherein R.sub.7 stands for hydrogen or benzyl group and R.sub.1, R.sub.2 and n each have the same meanings as defined above, or an acid addition salt thereof with epichlorohydrine optionally in the presence of a base.The new compounds of the general formula (I) and their acid addition salts inhibit the reproduction of viruses and can be used in therapy as antiviral agents.Type: GrantFiled: April 24, 1974Date of Patent: March 2, 1976Assignee: Richter Gedeon Vegyeszeti Gyar RtInventors: Olga Hankovszky, Kalman Hideg, Sandor Pacsa
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Patent number: 3932395Abstract: New tricyclic fused imidazole derivatives of the general formula (I), ##SPC1##whereinR.sub.1 stands for hydrogen or hydroxy,n is equal to zero or one,m is equal to zero, one or two,A stands for a group of the general formula (II), ##EQU1## wherein R.sub.2 represents hydrogen or hydroxy,R.sub.3 represents hydrogen or amino, orQ and Z each stand for nitrogen or a =C-- group, orA stands for a group of the general formula (III), ##EQU2## wherein R.sub.4 and R.sub.5 each represent hydrogen, methyl, chlorine or nitro,Were prepared by reacting a compound of the general formula (IV) ##SPC2##wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), ##EQU3## wherein X stands for halogen, R.sub.6 stands for hydrogen and R.sub.7 stands for a group of the general formula (VI),--(CH.sub.2).sub.m --X (VI)in which m and X each have the same meanings as defined above, or R.sub.6 and R.sub.7 together stand for oxygen.Type: GrantFiled: May 24, 1974Date of Patent: January 13, 1976Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Kalman Hideg, Olga Hankovszky, Eva Palosi, Gyorgy Hajos, Laszlo Szporny