Abstract: In one or more embodiments, the present invention provide a polyisobutylene-based polyurethane-urea, and related method of preparation, wherein PIB-diols form the soft segment and a diisocyanate along with a well-defined combinations low molecular weight diol chain extenders and amino alcohol as co-chain extenders form the hard segments. In one or more embodiments, the present invention is directed to the use of judiciously chosen chain extender/co-chain extender combinations to enhance the strength of PUs by partially replacing urethane groups with urea groups by the use of amino alcohols to improve strength, while maintaining good processability. These thermoplastic PIB-PUU elastomers exhibit heretofore unattainable combinations of mechanical properties and processability.

Abstract: Sulfur containing, hydroxyl-telechelic PIBs, hydrolytically and oxidatively resistant, biocompatible and biostable polyurethanes (PUs) made therefrom, and methods for making both are disclosed. Well-defined hydroxyl telechelic PIBs are synthesized by a thiol-ene click photochemical reaction between PIBs carrying unsaturated end groups and 2-mercaptoethanol (HS—CH2CH2—OH). This regioselective process affords HO—CH2CH2—S-PIB-S—CH2CH2—OH (abbreviated herein as HO—S-PIB-S—OH) in high yield. In some embodiments, these HO—S-PIB-S—OH polymers may be reacted with diisocyanates and a chain extender to form sulfur containing PIB-based PUs. These sulfur containing PIB-based PUs have been found to have properties and chemical stability that are very similar to that of PUs made from di-hydroxyl terminated PIBs (OH-PIB-OHs) without sulfur, but have surprisingly increased creep resistance and are easier and less expensive to make.

Abstract: In one or more embodiments, the present invention provide a polyisobutylene-based polyurethane-urea, and related method of preparation, wherein PIB-diols form the soft segment and a diisocyanate along with a well-defined combinations low molecular weight diol chain extenders and amino alcohol as co-chain extenders form the hard segments. In one or more embodiments, the present invention is directed to the use of judiciously chosen chain extender/co-chain extender combinations to enhance the strength of PUs by partially replacing urethane groups with urea groups by the use of amino alcohols to improve strength, while maintaining good processability. These thermoplastic PIB-PUU elastomers exhibit heretofore unattainable combinations of mechanical properties and processability.

Abstract: The invention relates to a compound selected from the group consisting of desethylamiodarone and pharmaceutically acceptable salts, hydrates and solvates thereof, as well as pharmaceutical composition comprising the compound together with a pharmaceutically acceptable excipient, vehicle or carrier, for use in the treatment of cancer.

Abstract: Sulfur containing, hydroxyl-telechelic PIBs, hydrolytically and oxidatively resistant, biocompatible and biostable polyurethanes (PUs) made therefrom, and methods for making both are disclosed. Well-defined hydroxyl telechelic PIBs are synthesized by a thiol-ene click photochemical reaction between PIBs carrying unsaturated end groups and 2-mercaptoethanol (HS—CH2CH2—OH). This regioselective process affords HO—CH2CH2—S-PIB-S—CH2CH2—OH (abbreviated herein as HO—S-PIB-S—OH) in high yield. In some embodiments, these HO—S-PIB-S—OH polymers may be reacted with diisocyanates and a chain extender to form sulfur containing PIB-based PUs. These sulfur containing PIB-based PUs have been found to have properties and chemical stability that are very similar to that of PUs made from di-hydroxyl terminated PIBs (OH-PIB-OHs) without sulfur, but have surprisingly increased creep resistance and are easier and less expensive to make.

Abstract: The invention relates to a compound selected from the group consisting of desethylamiodarone and pharmaceutically acceptable salts, hydrates and solvates thereof, as well as pharmaceutical composition comprising the compound together with a pharmaceutically acceptable excipient, vehicle or carrier, for use in the treatment of cancer.

Abstract: The invention relates to an apparatus for the construction of monolithic of multi-level or pillar-framed buildings having suspended ceilings, said apparatus is provided with surface- and in given case working level-forming formwork shell surrounding the monolithic concrete form-space of the ceiling, formwork bearer supporting the formwork shell, furthermore actuating mechanisms, e.g. lifting units for lifting and lowering the formwork bearer, the actuating mechanism, e.g. lifting units are in force-transmitting connection directly or indirectly with a certain part, e.g. pillars of the temporary or permanent vertical load bearing structures of the building, load bearing elements, e.g. bear frame, connecting member, etc. are built in between the formwork bearer and the lifting units.

Abstract: A computer aided stenographic system for rapidly transferring information from a written or spoken form into a typewriter or printed form. The stenographic system consists of software to translate a unique stenographic code into an actual word, or dictionary stored in computer memory for storing words retrievable with the unique stenographic code and additional apparatus to store entered text and transfer the text to a word processing device.

Abstract: A magnetic toy is provided which is capable of teaching basic scientific principles, provides a high degree of challenge to the user in operation and is low in cost. The toy has a plurality of bar magnets rotatably mounted between upper and lower support surfaces and a magnetic wand element. When the magnetic wand element is moved in the vicinity of the bar magnets one or more of the bar magnets will move and will also rotate with proper use of the magnetic wand.

Abstract: The invention relates to expanded products made from riolite glasses with a natural water content of at least 4 % by weight, as well as to a process for the preparation of such products. When preparing these expanded products a granulometric fraction of 0.3 to 3.0 mm. of the natural riolite glass is subjected to a heat treatment at 220.degree. to 400.degree. C for at least one hour, to reach a residual water content of 1 to 4 % by weight, and the obtained partially dehydrated substance is expanded at 800.degree. to 1300.degree. C. This way expanded products with high quality can be obtained.