Patents by Inventor Kalyan Kumar Pasunooti

Kalyan Kumar Pasunooti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ITRACONAZOLE ANALOGS AND USE THEREOF
    Publication number: 20220363672
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Application
    Filed: April 30, 2021
    Publication date: November 17, 2022
    Inventors: Jun O. Liu, Yingjun Li, Kalyan Kumar Pasunooti, Wukun Liu, Wei Shi, Ruojing Li, Sarah Head
  • ITRACONAZOLE ANALOGS AND USE THEREOF
    Publication number: 20220106302
    Abstract: Itraconazole, a widely used antifungal drug, has been found to possess potent anti-angiogenic and anti-hedgehog activities, exhibiting promising antitumor activity in several human clinical studies. The wider use of itraconazole in the treatment of cancer, however, has been limited by its potent inhibition of the drug metabolic enzyme CYP3A4 which causes drug-drug interactions. In an effort to eliminate the CYP3A4 inhibition of itraconazole while retaining its anti-angiogenic activity, we synthesized a series of itraconazole derivatives. The newly synthesized analogs of itraconazole were evaluated for their cytotoxicity against human umbilical vein endothelial cells (HUVEC) and their inhibitory activity against CYP3A4 enzyme.
    Type: Application
    Filed: October 3, 2019
    Publication date: April 7, 2022
    Inventors: Jun Liu, Yingjun Li, Kalyan Kumar Pasunooti, Wukun Liu, Wei Shi, Ruojing Li, Sarah Head
  • Itraconazole analogs and use thereof
    Patent number: 11028078
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: June 8, 2021
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Yingjun Li, Kalyan Kumar Pasunooti, Wukun Liu, Wei Shi, Ruojing Li, Sarah Head
  • ITRACONAZOLE ANALOGS AND USE THEREOF
    Publication number: 20190040046
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Application
    Filed: October 4, 2018
    Publication date: February 7, 2019
    Inventors: Jun O. Liu, Yingjun Li, Kalyan Kumar Pasunooti, Wukun Liu, Wei Shi, Ruojing Li, Sarah Head
  • ITRACONAZOLE ANALOGS AND USE THEREOF
    Publication number: 20160264556
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Application
    Filed: May 23, 2016
    Publication date: September 15, 2016
    Inventors: Jun O. Liu, Wei Shi, Kalyan Kumar Pasunooti
  • Itraconazole analogs and use thereof
    Patent number: 9346791
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: May 24, 2016
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Wei Shi, Kalyan Kumar Pasunooti
  • Itraconazole Analogs and Use Thereof
    Publication number: 20140221393
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Application
    Filed: September 7, 2012
    Publication date: August 7, 2014
    Inventors: Jun O. Liu, Wei Shi, Kalyan Kumar Pasunooti