Abstract: The present invention provides membrane on a chip devices for studying lipid membranes. The devices are suitable for studying molecular interactions on lipid membranes with single-molecule resolution. The devices are also are applicable to the study of membrane properties, interactions between membranes and vesicles, viruses, bacteria, and the like, and trafficking of compounds across the membrane, among others. The devices are readily amenable to a variety of microscopy and spectroscopy techniques.

Abstract: A method comprises extracting first task data from a first data source corresponding to a first application and second task data from a second data source corresponding to a second application, and comparing the first task data to the second task data using one or more natural language processing techniques. In the method, one or more matching tasks between the first task data and the second task data are identified based at least in part on the comparing. Code of at least one of the first application and the second application is analyzed to determine whether the code of at least one of the first application and the second application implements the one or more matching tasks.

Abstract: A system and method for determining a lowest purchase method and/or combination of purchase methods for purchasing one or more medical products, such as prescription drugs, and/or medical services, such as medical, dental, or veterinary procedures, wherein a lowest out-of-pocket expense to a user is determined based on various pricing variables, insurance reimbursement variables, and available discount programs obtained in-part from third-party data providers and third-party aggregators.

Abstract: A method comprises extracting first task data from a first data source corresponding to a first application and second task data from a second data source corresponding to a second application, and comparing the first task data to the second task data using one or more natural language processing techniques. In the method, one or more matching tasks between the first task data and the second task data are identified based at least in part on the comparing. Code of at least one of the first application and the second application is analyzed to determine whether the code of at least one of the first application and the second application implements the one or more matching tasks.

Abstract: Systems and methods for providing targeted event notifications to subscribers are disclosed. In an example embodiment, events may be received from a publisher. The events may be categorized into a plurality of topics. The events may be distributed among brokers to process a topic selected from the plurality of topics based on the events. Further, it may be determined whether the topic exists in a list of topics handled by the brokers. Authentication credentials of the publisher may be validated, based on the determination. Based on the validation, queues of the events may be formed based on an order of receipt of the events. The events present in the queues may be filtered based on subscriptions of the events. For the fileted events, targeted even notifications may be forwarded to the subscribers.

Abstract: Optimizations are provided for interconnecting event sources with event subscribers in a seamless manner so that the native formatting/schema methodologies used by event sources and subscribers will not need to be natively modified. An event grid service is provided as a routing and mapping service. This event grid service receives event data that may be organized in any kind of format. By analyzing the format, the event grid service determines whether the format correlates with a format used by a consumer of that event data. If the formats conform, then the event grid service extracts relevant data from the event data and pushes it to the subscriber. If the formats do not conform, the event grid service intelligently generates a mapping to map the two formats together.

Abstract: Systems and methods for filtering and routing event notifications to subscribers are disclosed. In an example embodiment, events from a publisher may be received. Each of the events may be associated with a topic, and the topic may be compared with topics present in broker metadata cache, based on one of prefixes and a fast lookup technique using a hash-table. Further, it may be determined whether the topic associated the events is present in the broker metadata cache based on comparison. Based upon determining, matching nodes for the events may be retrieved. Further, the events may be routed based on routing tables and availability of the matching nodes. Based on the routing, the events may be forwarded to the subscribers.

Abstract: Systems and methods for filtering and routing event notifications to subscribers are disclosed. In an example embodiment, events from a publisher may be received. Each of the events may be associated with a topic, and the topic may be compared with topics present in broker metadata cache, based on one of prefixes and a fast lookup technique using a hash-table. Further, it may be determined whether the topic associated the events is present in the broker metadata cache based on comparison. Based upon determining, matching nodes for the events may be retrieved. Further, the events may be routed based on routing tables and availability of the matching nodes. Based on the routing, the events may be forwarded to the subscribers.

Abstract: Systems and methods for dispatching targeted event notifications to subscribers are disclosed. In an embodiment, the system includes a receiver to receive events from a publisher. The system further comprises a router in communication with the receiver to route the events. The system further comprises a director to forward the targeted event notifications to the subscribers based on the routing. The director receives a delivery status of the targeted event notification from the subscribers. The delivery status includes one of success in receiving the targeted event notification and failure in receiving the targeted event notification. The director receives an event notification with the delivery status as failure in receiving the targeted event notification. The director places the targeted event notification in a delayed queue indicative of events to be delivered after a predefined time. The director re-transmits the targeted event notification to the subscribers based on the delayed queue.

Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.

Abstract: Systems and methods for dispatching targeted event notifications to subscribers are disclosed. In an example embodiment, a notification indicating creation of an even subscription by a subscriber may be received. An event source may be invoked to enable publishing of events corresponding to an event topic associated with the event subscription. A response from the event source for publishing of the events may be received and targeted event notifications may be forwarded to the subscribers on receiving the response.

Abstract: Publishing events. A method includes a publisher sending a message comprising one or more events to a domain. The domain is a container comprising a group of domain topics. Each domain topic in the domain is relevant by subject matter to the one or more events by virtue of belonging to the container. The method further includes, at the domain determining the appropriate domain topics from the group of domain topics for each event in the one or more events. The method further includes identifying subscribers to the appropriate domain topics. The method further includes sending notifications to the subscribers of the domain topics of the one or more events.

Abstract: Optimizations are provided for interconnecting event sources with event subscribers in a seamless manner so that the native formatting/schema methodologies used by event sources and subscribers will not need to be natively modified. An event grid service is provided as a routing and mapping service. This event grid service receives event data that may be organized in any kind of format. By analyzing the format, the event grid service determines whether the format correlates with a format used by a consumer of that event data. If the formats conform, then the event grid service extracts relevant data from the event data and pushes it to the subscriber. If the formats do not conform, the event grid service intelligently generates a mapping to map the two formats together.

Abstract: A method utilizing a system encompassing a free pool buffer; a deadlock avoidance buffer; and a controller communicatively coupled to the free pool buffer and the deadlock avoidance buffer to reorder out-of-order responses to fetch requests into correct order by: receiving a fetch request on behalf of a consumer; allocating space first in the free pool buffer and when such space is not available then allocating space in a division associated with the consumer in the deadlock avoidance buffer. Issuing segment(s) of the fetch request including associated tag(s) to one of one or more memories; writing response data for each of the segment(s) to the allocated space in the free buffer or the deadlock avoidance buffer according to each of the associated tag(s); and transferring the response data to the consumer according to an entry in an ordering first-in, first-out buffer and an entry in a pending request array.

Abstract: Systems and methods for providing targeted event notifications to subscribers are disclosed. In an example embodiment, events may be received from a publisher. The events may be categorized into a plurality of topics. The events may be distributed among brokers to process a topic selected from the plurality of topics based on the events. Further, it may be determined whether the topic exists in a list of topics handled by the brokers. Authentication credentials of the publisher may be validated, based on the determination. Based on the validation, queues of the events may be formed based on an order of receipt of the events. The events present in the queues may be filtered based on subscriptions of the events. For the fileted events, targeted even notifications may be forwarded to the subscribers.

Abstract: Optimizations are provided for interconnecting event sources with event subscribers in a seamless manner so that the native formatting/schema methodologies used by event sources and subscribers will not need to be natively modified. An event grid service is provided as a routing and mapping service. This event grid service receives event data that may be organized in any kind of format. By analyzing the format, the event grid service determines whether the format correlates with a format used by a consumer of that event data. If the formats conform, then the event grid service extracts relevant data from the event data and pushes it to the subscriber. If the formats do not conform, the event grid service intelligently generates a mapping to map the two formats together.

Abstract: A method and a system embodying the method for job pre-scheduling in a processing system comprising distributed job management, encompassing: determining a maximum amount of pre-schedulable jobs for each of a plurality of engines; setting for each of the plurality of engines a threshold less than or equal to the maximum amount; pre-scheduling by a scheduler an amount of jobs less than or equal to the threshold to at least one of a plurality of job managers; determining at the at least one of the plurality of job managers managing one of the plurality of engines one of a plurality of data processing devices in order for each pre-scheduled job; and assigning the job to the determined data processing device.

Abstract: Systems and methods for providing targeted event notifications to subscribers are disclosed. In an example embodiment, events may be received from a publisher. The events may be categorized into a plurality of topics. The events may be distributed among brokers to process a topic selected from the plurality of topics based on the events. Further, it may be determined whether the topic exists in a list of topics handled by the brokers. Authentication credentials of the publisher may be validated, based on the determination. Based on the validation, queues of the events may be formed based on an order of receipt of the events. The events present in the queues may be filtered based on subscriptions of the events. For the fileted events, targeted even notifications may be forwarded to the subscribers.

Abstract: Publishing events. A method includes a publisher sending a message comprising one or more events to a domain. The domain is a container comprising a group of domain topics. Each domain topic in the domain is relevant by subject matter to the one or more events by virtue of belonging to the container. The method further includes, at the domain determining the appropriate domain topics from the group of domain topics for each event in the one or more events. The method further includes identifying subscribers to the appropriate domain topics. The method further includes sending notifications to the subscribers of the domain topics of the one or more events.

Abstract: Optimizations are provided for interconnecting event sources with event subscribers in a seamless manner so that the native formatting/schema methodologies used by event sources and subscribers will not need to be natively modified. An event grid service is provided as a routing and mapping service. This event grid service receives event data that may be organized in any kind of format. By analyzing the format, the event grid service determines whether the format correlates with a format used by a consumer of that event data. If the formats conform, then the event grid service extracts relevant data from the event data and pushes it to the subscriber. If the formats do not conform, the event grid service intelligently generates a mapping to map the two formats together.