Publication number: 20180153919
Abstract: The present disclosure relates to RNAi agents useful in methods of treating KRAS-related diseases such as a proliferative disease, including without limitation a solid or liquid cancer, adenocarcinoma, colorectal cancer, advanced and/or metastatic colorectal cancer, colon cancer, lung, non-small cell lung cancer and lung adenocarcinoma, acute myelogenous lung, bladder, brain, breast, cervical, endometrial, gastric, head and neck, kidney, leukemia, myelodysplastic syndrome, myeloid leukemia, liver, melanoma, ovarian, pancreatic, prostate, testicular, thyroid cancers, and cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to KRAS.
Type:
Application
Filed:
September 7, 2016
Publication date:
June 7, 2018
Inventors:
Brian Bettencourt, Stuart Milstein, Ivanka Toudjarska, Earl McDonald, Michael Schlabach, JR., Frank P. Stegmeier, Markus Warmuth, Kalyani Gampa, Dieter Huesken, Mark Stump, Jan Weiler, Zainab Jagani
Publication number: 20150238515
Abstract: The present disclosure relates to RNAi agents useful in methods of treating KRAS-related diseases such as a proliferative disease, including without limitation a solid or liquid cancer, adenocarcinoma, colorectal cancer, advanced and/or metastatic colorectal cancer, colon cancer, lung, non-small cell lung cancer and lung adenocarcinoma, acute myelogenous lung, bladder, brain, breast, cervical, endometrial, gastric, head and neck, kidney, leukemia, myelodysplastic syndrome, myeloid leukemia, liver, melanoma, ovarian, pancreatic, prostate, testicular, thyroid cancers, and cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to KRAS.
Type:
Application
Filed:
April 30, 2013
Publication date:
August 27, 2015
Inventors:
Brian Bettencourt, Stuart Milstein, Ivanka Jarska, Earl McDonald, Michael Schlabach, JR., Frank P. Stegmeier, Markus Warmuth, Kalyani Gampa, Dieter Huesken, Mark Stump, Jan Weiler, Zainab Jagani