Patents by Inventor Kalyani Mangipudi

Kalyani Mangipudi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-REPLICATIVE TRANSDUCTION PARTICLES WITH ONE OR MORE NON-NATIVE TAIL FIBERS AND TRANSDUCTION PARTICLE-BASED REPORTER SYSTEMS
    Publication number: 20230272491
    Abstract: The present invention relates to compositions comprising and methods of producing genetically engineered bacteriophages, bacteriophage-like particles and non-replicating transduction particles (NRTPs) that contain non-native tail fibers that display altered host specificity and/or reactivity. The present invention also relates to methods of using these bacteriophages and NRTPs for the development of novel diagnostics, therapeutics and/or research reagents for bacteria-related diseases.
    Type: Application
    Filed: January 10, 2023
    Publication date: August 31, 2023
    Inventors: Kyle C. Cady, Colin Lam, Jeffrey Alexander, Kristina Chu, Barbara Eckert, Dylan Goldman, Patrick Lin, Kalyani Mangipudi, Misha Mehta, Arrash Moghaddasi, Hai Nguyen, Natacha Sorenson
  • COMPOSITIONS AND METHODS FOR DETECTION OF MYCOPLASMA GENITALIUM
    Publication number: 20230143647
    Abstract: Methods for the rapid detection of the presence or absence of Mycoplasma genitalium (MG) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target MG gene, along with kits are provided that are designed for the detection of MG.
    Type: Application
    Filed: January 12, 2023
    Publication date: May 11, 2023
    Inventors: Jody Harris, Kalyani Mangipudi
  • Compositions and methods for detection of
    Patent number: 11591659
    Abstract: Methods for the rapid detection of the presence or absence of Mycoplasma genitalium (MG) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target MG gene, along with kits are provided that are designed for the detection of MG.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: February 28, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jody Harris, Kalyani Mangipudi
  • Non-replicative transduction particles with one or more non-native tail fibers and transduction particle-based reporter systems
    Patent number: 11572595
    Abstract: The present invention relates to compositions comprising and methods of producing genetically engineered bacteriophages, bacteriophage-like particles and non-replicating transduction particles (NRTPs) that contain non-native tail fibers that display altered host specificity and/or reactivity. The present invention also relates to methods of using these bacteriophages and NRTPs for the development of novel diagnostics, therapeutics and/or research reagents for bacteria-related diseases.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: February 7, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Kyle C. Cady, Colin Lam, Jeffrey Alexander, Kristina Chu, Barbara Eckert, Dylan Goldman, Patrick Lin, Kalyani Mangipudi, Misha Mehta, Arrash Moghaddasi, Hai Nguyen, Natacha Sorenson
  • COMPOSITIONS AND METHODS FOR DETECTING SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2) VARIANTS HAVING SPIKE PROTEIN MUTATIONS
    Publication number: 20220290221
    Abstract: Methods for the rapid detection of the presence of variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that contain mutations in the Spike (S) protein gene in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting SARS-CoV-2 variants containing S gene mutations and kits are provided that are designed for the detection of SARS-CoV-2 variants containing S gene mutations.
    Type: Application
    Filed: March 11, 2022
    Publication date: September 15, 2022
    Inventors: Chitra Manohar, Marcel R. Fontecha, Christopher David Santini, Eugene Spier, Jingtao Sun, Michelle Elizabeth Yee, Kalyani Mangipudi
  • COMPOSITIONS AND METHODS FOR DETECTING SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2), INFLUENZA A AND INFLUENZA B
    Publication number: 20210285061
    Abstract: Methods for the rapid detection of the presence or absence of SARS-CoV-2, influenza A and influenza B in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting SARS-CoV-2, influenza A, and influenza B and kits are provided that are designed for the detection of SARS-CoV-2, influenza A and influenza B.
    Type: Application
    Filed: March 8, 2021
    Publication date: September 16, 2021
    Inventors: Chitra Manohar, Marcel R. Fontecha, Marintha Heil, Ramani Sadanandam Ravirala, Christopher David Santini, Eugene Spier, Jingtao Sun, Thanh Tam, Huan Truong, Michelle Elizabeth Yee, Kalyani Mangipudi
  • COMPOSITIONS AND METHODS FOR DETECTION OF TRICHOMONAS VAGINALIS
    Publication number: 20210147949
    Abstract: Methods for the rapid detection of the presence or absence of Trichomonas vaginalis (TV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target TV gene, along with kits are provided that are designed for the detection of TV.
    Type: Application
    Filed: January 22, 2021
    Publication date: May 20, 2021
    Inventors: Jody Harris, Shi-Da Y. Lu, Kalyani Mangipudi, Jingtao Sun
  • Compositions and methods for detection of trichomonas vaginalis
    Patent number: 10934597
    Abstract: Methods for the rapid detection of the presence or absence of Trichomonas vaginalis (TV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target TV gene, along with kits are provided that are designed for the detection of TV.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: March 2, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jody Harris, Shi-Da Y. Lu, Kalyani Mangipudi, Jingtao Sun
  • NON-REPLICATIVE TRANSDUCTION PARTICLES WITH ONE OR MORE NON-NATIVE TAIL FIBERS AND TRANSDUCTION PARTICLE-BASED REPORTER SYSTEMS
    Publication number: 20200208226
    Abstract: The present invention relates to compositions comprising and methods of producing genetically engineered bacteriophages, bacteriophage-like particles and non-replicating transduction particles (NRTPs) that contain non-native tail fibers that display altered host specificity and/or reactivity. The present invention also relates to methods of using these bacteriophages and NRTPs for the development of novel diagnostics, therapeutics and/or research reagents for bacteria-related diseases.
    Type: Application
    Filed: December 20, 2019
    Publication date: July 2, 2020
    Inventors: Kyle C. Cady, Colin Lam, Jeffrey Alexander, Kristina Chu, Barbara Eckert, Dylan Goldman, Patrick Lin, Kalyani Mangipudi, Misha Mehta, Arrash Moghaddasi, Hai Nguyen, Natacha Sorenson
  • COMPOSITIONS AND METHODS FOR DETECTION OF MYCOPLASMA GENITALIUM
    Publication number: 20200181691
    Abstract: Methods for the rapid detection of the presence or absence of Mycoplasma genitalium (MG) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target MG gene, along with kits are provided that are designed for the detection of MG.
    Type: Application
    Filed: February 25, 2020
    Publication date: June 11, 2020
    Inventors: Jody Harris, Kalyani Mangipudi
  • Compositions and methods for detection of
    Patent number: 10612101
    Abstract: Methods for the rapid detection of the presence or absence of Mycoplasma genitalium (MG) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target MG gene, along with kits are provided that are designed for the detection of MG.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: April 7, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jody Harris, Kalyani Mangipudi
  • COBRA PROBES TO DETECT A MARKER FOR EPIDEMIC RIBOTYPES OF CLOSTRIDIUM DIFFICILE
    Publication number: 20190211377
    Abstract: Methods for the rapid detection of the presence or absence of a single-base deletion in the tcdC gene of Clostridium difficile in a biological or nonbiological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes, and kits are provided that are designed for the detection of the single-base deletion.
    Type: Application
    Filed: December 18, 2017
    Publication date: July 11, 2019
    Inventors: Kalyani Mangipudi, Jenny A Johnson, Stephen G Will
  • INTERNAL CONTROL PROBES FOR IMPROVING PCR ASSAY PERFORMANCE
    Publication number: 20170356025
    Abstract: The present invention relates to methods for improving multiplex real-time PCR assays by the use of an internal control probe labeled with Quasar 705.
    Type: Application
    Filed: June 9, 2017
    Publication date: December 14, 2017
    Inventor: Kalyani Mangipudi
  • COMPOSITIONS AND METHODS FOR DETECTION OF TRICHOMONAS VAGINALIS
    Publication number: 20170342508
    Abstract: Methods for the rapid detection of the presence or absence of Trichomonas vaginalis (TV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target TV gene, along with kits are provided that are designed for the detection of TV.
    Type: Application
    Filed: May 22, 2017
    Publication date: November 30, 2017
    Inventors: Jody Harris, Shi-Da Y. Lu, Kalyani Mangipudi, Jingtao Sun
  • COMPOSITIONS AND METHODS FOR DETECTION OF MYCOPLASMA GENITALIUM
    Publication number: 20170342468
    Abstract: Methods for the rapid detection of the presence or absence of Mycoplasma genitalium (MG) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target MG gene, along with kits are provided that are designed for the detection of MG.
    Type: Application
    Filed: May 22, 2017
    Publication date: November 30, 2017
    Inventors: Jody Harris, Kalyani Mangipudi